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Title: Radiation-induced molecular modulations in thyroid cells cultured under iodine-deficiency
Author(s): Ramadan, Raghda
Derradji, Hanane
Keywords: Radiation- Iodine deficiency- Thyroid cancer
Issue Date: 12-Sep-2014
Publication type: Thesis
Citation: Ramadan R.- Radiation-induced molecular modulations in thyroid cells cultured under iodine-deficiency.- Hasselt, Belgium: Hasselt University, 2014.- 32 p.- Master thesis
Abstract: We are exposed to natural radiations from different sources on a daily basis. In addition to the background radiation, some people receive artificial radiations for diagnostic or therapeutic purposes. Unlike the effects of high radiation doses which are known, the effects of low radiations doses are still unclear. Besides radiation, two billion people are suffering from iodine deficiency worldwide, iodine deficiency have many consequences such as endemic goiter, growth retardation and it is a risk factor for thyroid cancer. As both radiation and iodine deficiency induce harmful effects on thyroid cells separately and there are little knowledge about their combined effects, the current study was undertaken to understand the basic mechanisms of thyroid cancer risks after low radiation dose exposure under iodine deficiency. One potential mechanism by which external radiation and iodine deficiency would merge their harmful effects is the increase of ROS production at a level that becomes deleterious enough to trigger tumor initiation. This study shows that irradiation and iodine deficiency induce molecular changes in the thyroid cells that lead to the activation of pro-survival pathways and apoptosis escape, two mechanisms characteristic of cancer cells. Thus irradiation and iodine deficiency may be potential risk factors for thyroid cancer.
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