520-d Isolation and confinement simulating a flight to Mars reveals heightened immune responses and alterations of leukocyte phenotype

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520-d Isolation and confinement simulating a flight to Mars reveals heightened immune responses and alterations of leukocyte phenotype. / Yi, B.; Rykova, M.; Feuerecker, M.; Jäger, B.; Ladinig, C.; Basner, M.; Hörl, M.; Matzel, S.; Kaufmann, I.; Strewe, C.; Nichiporuk, I.; Vassilieva, G.; Rinas, K.; Baatout, Sarah; Schelling, G.; Thiel, G.; Dinges, D.F.; Morukov, B.; Choukèr, A.

In: Brain, Behavior, and Immunity, Vol. 40, 02.04.2015, p. 203-210.

Research output: Contribution to journalArticle

Harvard

Yi, B, Rykova, M, Feuerecker, M, Jäger, B, Ladinig, C, Basner, M, Hörl, M, Matzel, S, Kaufmann, I, Strewe, C, Nichiporuk, I, Vassilieva, G, Rinas, K, Baatout, S, Schelling, G, Thiel, G, Dinges, DF, Morukov, B & Choukèr, A 2015, '520-d Isolation and confinement simulating a flight to Mars reveals heightened immune responses and alterations of leukocyte phenotype', Brain, Behavior, and Immunity, vol. 40, pp. 203-210. https://doi.org/10.1016/j.bbi.2014.03.018

APA

Yi, B., Rykova, M., Feuerecker, M., Jäger, B., Ladinig, C., Basner, M., ... Choukèr, A. (2015). 520-d Isolation and confinement simulating a flight to Mars reveals heightened immune responses and alterations of leukocyte phenotype. Brain, Behavior, and Immunity, 40, 203-210. https://doi.org/10.1016/j.bbi.2014.03.018

Vancouver

Yi B, Rykova M, Feuerecker M, Jäger B, Ladinig C, Basner M et al. 520-d Isolation and confinement simulating a flight to Mars reveals heightened immune responses and alterations of leukocyte phenotype. Brain, Behavior, and Immunity. 2015 Apr 2;40:203-210. https://doi.org/10.1016/j.bbi.2014.03.018

Author

Yi, B. ; Rykova, M. ; Feuerecker, M. ; Jäger, B. ; Ladinig, C. ; Basner, M. ; Hörl, M. ; Matzel, S. ; Kaufmann, I. ; Strewe, C. ; Nichiporuk, I. ; Vassilieva, G. ; Rinas, K. ; Baatout, Sarah ; Schelling, G. ; Thiel, G. ; Dinges, D.F. ; Morukov, B. ; Choukèr, A. / 520-d Isolation and confinement simulating a flight to Mars reveals heightened immune responses and alterations of leukocyte phenotype. In: Brain, Behavior, and Immunity. 2015 ; Vol. 40. pp. 203-210.

Bibtex - Download

@article{ef5f868454cc4bc0ba02863c8fd5af6a,
title = "520-d Isolation and confinement simulating a flight to Mars reveals heightened immune responses and alterations of leukocyte phenotype",
abstract = "During interplanetary exploration, chronic stress caused by long term isolation and confinement in the spacecraft is one of the major concerns of physical and psychological health of space travelers. And for human on Earth, more and more people live in an isolated condition, which has become a common social problem in modern western society. Collective evidences have indicated prolonged chronic stress could bring big influence to human immune function, which may lead to a variety of health problems. However, to what extent long-term isolation can affect the immune system still remains largely unknow. A simulated 520-d Mars mission provided an extraordinary chance to study the effect of prolonged isolation. Six healthy males participated in this mission and their active neuroendocrine and immune conditions were studied with saliva and blood samples from all participants on chosen time points during the isolation period. As a typical neuroendocrine parameter, stress hormone cortisol was measured in the morning saliva samples. The results of this study revealed elevated cortisol levels, increased lymphocyte amount and heightened immune responses, suggesting that prolonged isolation acting as chronic stressors are able to trigger leukocyte phenotype changes and poorly controlled immune responses.",
keywords = "Chronic stress, inflammation, lymphocyte, cortisol",
author = "B. Yi and M. Rykova and M. Feuerecker and B. J{\"a}ger and C. Ladinig and M. Basner and M. H{\"o}rl and S. Matzel and I. Kaufmann and C. Strewe and I. Nichiporuk and G. Vassilieva and K. Rinas and Sarah Baatout and G. Schelling and G. Thiel and D.F. Dinges and B. Morukov and A. Chouk{\`e}r",
note = "Score = 10",
year = "2015",
month = "4",
day = "2",
doi = "10.1016/j.bbi.2014.03.018",
language = "English",
volume = "40",
pages = "203--210",
journal = "Brain, Behavior, and Immunity",
issn = "0889-1591",
publisher = "Elsevier",

}

RIS - Download

TY - JOUR

T1 - 520-d Isolation and confinement simulating a flight to Mars reveals heightened immune responses and alterations of leukocyte phenotype

AU - Yi, B.

AU - Rykova, M.

AU - Feuerecker, M.

AU - Jäger, B.

AU - Ladinig, C.

AU - Basner, M.

AU - Hörl, M.

AU - Matzel, S.

AU - Kaufmann, I.

AU - Strewe, C.

AU - Nichiporuk, I.

AU - Vassilieva, G.

AU - Rinas, K.

AU - Baatout, Sarah

AU - Schelling, G.

AU - Thiel, G.

AU - Dinges, D.F.

AU - Morukov, B.

AU - Choukèr, A.

N1 - Score = 10

PY - 2015/4/2

Y1 - 2015/4/2

N2 - During interplanetary exploration, chronic stress caused by long term isolation and confinement in the spacecraft is one of the major concerns of physical and psychological health of space travelers. And for human on Earth, more and more people live in an isolated condition, which has become a common social problem in modern western society. Collective evidences have indicated prolonged chronic stress could bring big influence to human immune function, which may lead to a variety of health problems. However, to what extent long-term isolation can affect the immune system still remains largely unknow. A simulated 520-d Mars mission provided an extraordinary chance to study the effect of prolonged isolation. Six healthy males participated in this mission and their active neuroendocrine and immune conditions were studied with saliva and blood samples from all participants on chosen time points during the isolation period. As a typical neuroendocrine parameter, stress hormone cortisol was measured in the morning saliva samples. The results of this study revealed elevated cortisol levels, increased lymphocyte amount and heightened immune responses, suggesting that prolonged isolation acting as chronic stressors are able to trigger leukocyte phenotype changes and poorly controlled immune responses.

AB - During interplanetary exploration, chronic stress caused by long term isolation and confinement in the spacecraft is one of the major concerns of physical and psychological health of space travelers. And for human on Earth, more and more people live in an isolated condition, which has become a common social problem in modern western society. Collective evidences have indicated prolonged chronic stress could bring big influence to human immune function, which may lead to a variety of health problems. However, to what extent long-term isolation can affect the immune system still remains largely unknow. A simulated 520-d Mars mission provided an extraordinary chance to study the effect of prolonged isolation. Six healthy males participated in this mission and their active neuroendocrine and immune conditions were studied with saliva and blood samples from all participants on chosen time points during the isolation period. As a typical neuroendocrine parameter, stress hormone cortisol was measured in the morning saliva samples. The results of this study revealed elevated cortisol levels, increased lymphocyte amount and heightened immune responses, suggesting that prolonged isolation acting as chronic stressors are able to trigger leukocyte phenotype changes and poorly controlled immune responses.

KW - Chronic stress

KW - inflammation

KW - lymphocyte

KW - cortisol

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_139787

UR - http://knowledgecentre.sckcen.be/so2/bibref/12776

U2 - 10.1016/j.bbi.2014.03.018

DO - 10.1016/j.bbi.2014.03.018

M3 - Article

VL - 40

SP - 203

EP - 210

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

SN - 0889-1591

ER -

ID: 207232