A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis

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A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis. / Verreet, Tine; Quintens, Roel; Van Dam, Debby; Verslegers, Mieke; Tanori, Mirella; Casciati, Arianna; Neefs, Mieke; Leysen, Liselotte; Michaux, Arlette; Janssen, Ann; D'Agostino, Emiliano; Vande Velde, Greetje; Baatout, Sarah; Moons, Lieve; Pazzaglia, Simonetta; Saran, Anna; Himmelreich, Uwe; De Deyn, Peter Paul; Benotmane, Rafi.

In: Journal of Neurodevelopmental Disorders, Vol. 7, No. 3, 01.2015, p. 1-21.

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Verreet, T, Quintens, R, Van Dam, D, Verslegers, M, Tanori, M, Casciati, A, Neefs, M, Leysen, L, Michaux, A, Janssen, A, D'Agostino, E, Vande Velde, G, Baatout, S, Moons, L, Pazzaglia, S, Saran, A, Himmelreich, U, De Deyn, PP & Benotmane, R 2015, 'A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis', Journal of Neurodevelopmental Disorders, vol. 7, no. 3, pp. 1-21. https://doi.org/10.1186/1866-1955-7-3

Author

Verreet, Tine ; Quintens, Roel ; Van Dam, Debby ; Verslegers, Mieke ; Tanori, Mirella ; Casciati, Arianna ; Neefs, Mieke ; Leysen, Liselotte ; Michaux, Arlette ; Janssen, Ann ; D'Agostino, Emiliano ; Vande Velde, Greetje ; Baatout, Sarah ; Moons, Lieve ; Pazzaglia, Simonetta ; Saran, Anna ; Himmelreich, Uwe ; De Deyn, Peter Paul ; Benotmane, Rafi. / A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis. In: Journal of Neurodevelopmental Disorders. 2015 ; Vol. 7, No. 3. pp. 1-21.

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@article{6709c461eaec4c74813bdfccbec9c566,
title = "A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis",
abstract = "In humans, in utero exposure to ionising radiation results in an increased prevalence of neurological aberrations, such as small head size, mental retardation and decreased IQ levels. Yet, the association between early damaging events and long-term neuronal anomalies remains largely elusive. Mice were exposed to different X-ray doses, ranging between 0.0 and 1.0 Gy, at embryonic days (E) 10, 11 or 12 and subjected to behavioural tests at 12 weeks of age. Underlying mechanism of irradiation at E11 were further unravelled using magnetic resonance imaging (MRI) and spectroscopy, diffusion tensor imaging, gene expression profiling, histology and immunohistochemistry. Our findings provide evidence for a radiation-induced disruption of mouse brain development, resulting in behavioural differences. We propose that alterations in cortical morphology and juvenile hippocampal neurogenesis might both contribute to the observed aberrant behaviour. Furthermore, our results challenge the generally assumed view of a higher radiosensitivity in dividing cells. Overall, this study offers new insights into irradiation-dependent effects in the embryonic brain, of relevance for the neurodevelopmental and radiobiological field.",
keywords = "Apoptosis, Brain development, Cognitive dysfunction, MRI, Radiation",
author = "Tine Verreet and Roel Quintens and {Van Dam}, Debby and Mieke Verslegers and Mirella Tanori and Arianna Casciati and Mieke Neefs and Liselotte Leysen and Arlette Michaux and Ann Janssen and Emiliano D'Agostino and {Vande Velde}, Greetje and Sarah Baatout and Lieve Moons and Simonetta Pazzaglia and Anna Saran and Uwe Himmelreich and {De Deyn}, {Peter Paul} and Rafi Benotmane",
note = "Score = 10",
year = "2015",
month = "1",
doi = "10.1186/1866-1955-7-3",
language = "English",
volume = "7",
pages = "1--21",
journal = "Journal of Neurodevelopmental Disorders",
issn = "1866-1955",
publisher = "Springer",
number = "3",

}

RIS - Download

TY - JOUR

T1 - A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis

AU - Verreet, Tine

AU - Quintens, Roel

AU - Van Dam, Debby

AU - Verslegers, Mieke

AU - Tanori, Mirella

AU - Casciati, Arianna

AU - Neefs, Mieke

AU - Leysen, Liselotte

AU - Michaux, Arlette

AU - Janssen, Ann

AU - D'Agostino, Emiliano

AU - Vande Velde, Greetje

AU - Baatout, Sarah

AU - Moons, Lieve

AU - Pazzaglia, Simonetta

AU - Saran, Anna

AU - Himmelreich, Uwe

AU - De Deyn, Peter Paul

AU - Benotmane, Rafi

N1 - Score = 10

PY - 2015/1

Y1 - 2015/1

N2 - In humans, in utero exposure to ionising radiation results in an increased prevalence of neurological aberrations, such as small head size, mental retardation and decreased IQ levels. Yet, the association between early damaging events and long-term neuronal anomalies remains largely elusive. Mice were exposed to different X-ray doses, ranging between 0.0 and 1.0 Gy, at embryonic days (E) 10, 11 or 12 and subjected to behavioural tests at 12 weeks of age. Underlying mechanism of irradiation at E11 were further unravelled using magnetic resonance imaging (MRI) and spectroscopy, diffusion tensor imaging, gene expression profiling, histology and immunohistochemistry. Our findings provide evidence for a radiation-induced disruption of mouse brain development, resulting in behavioural differences. We propose that alterations in cortical morphology and juvenile hippocampal neurogenesis might both contribute to the observed aberrant behaviour. Furthermore, our results challenge the generally assumed view of a higher radiosensitivity in dividing cells. Overall, this study offers new insights into irradiation-dependent effects in the embryonic brain, of relevance for the neurodevelopmental and radiobiological field.

AB - In humans, in utero exposure to ionising radiation results in an increased prevalence of neurological aberrations, such as small head size, mental retardation and decreased IQ levels. Yet, the association between early damaging events and long-term neuronal anomalies remains largely elusive. Mice were exposed to different X-ray doses, ranging between 0.0 and 1.0 Gy, at embryonic days (E) 10, 11 or 12 and subjected to behavioural tests at 12 weeks of age. Underlying mechanism of irradiation at E11 were further unravelled using magnetic resonance imaging (MRI) and spectroscopy, diffusion tensor imaging, gene expression profiling, histology and immunohistochemistry. Our findings provide evidence for a radiation-induced disruption of mouse brain development, resulting in behavioural differences. We propose that alterations in cortical morphology and juvenile hippocampal neurogenesis might both contribute to the observed aberrant behaviour. Furthermore, our results challenge the generally assumed view of a higher radiosensitivity in dividing cells. Overall, this study offers new insights into irradiation-dependent effects in the embryonic brain, of relevance for the neurodevelopmental and radiobiological field.

KW - Apoptosis

KW - Brain development

KW - Cognitive dysfunction

KW - MRI

KW - Radiation

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_138207

UR - http://knowledgecentre.sckcen.be/so2/bibref/12214

U2 - 10.1186/1866-1955-7-3

DO - 10.1186/1866-1955-7-3

M3 - Article

VL - 7

SP - 1

EP - 21

JO - Journal of Neurodevelopmental Disorders

JF - Journal of Neurodevelopmental Disorders

SN - 1866-1955

IS - 3

ER -

ID: 153935