A novel methodology to assess linear energy transfer and relative biological effectiveness in proton therapy using pairs of differently doped thermoluminescent detectors

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A novel methodology to assess linear energy transfer and relative biological effectiveness in proton therapy using pairs of differently doped thermoluminescent detectors. / Parisi, Alessio; Chiriotti Alvarez, Sabina; De Saint-Hubert, Marijke; Van Hoey, Olivier; Vandevoorde, Charlot; Beukes, Philip; de Kock, Evan Alexander; Symons, Julyan; Nieto-Camero, Jaime; Slabbert, Jacobus; Mégret, Patrice; Debrot, Emily; Bolst, David; Rosenfeld, Anatoly; Vanhavere, Filip.

In: Physics in Medicine and Biology, Vol. 64, 085005, 05.04.2019, p. 1-17.

Research output: Contribution to journalArticle

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Parisi, A, Chiriotti Alvarez, S, De Saint-Hubert, M, Van Hoey, O, Vandevoorde, C, Beukes, P, de Kock, EA, Symons, J, Nieto-Camero, J, Slabbert, J, Mégret, P, Debrot, E, Bolst, D, Rosenfeld, A & Vanhavere, F 2019, 'A novel methodology to assess linear energy transfer and relative biological effectiveness in proton therapy using pairs of differently doped thermoluminescent detectors' Physics in Medicine and Biology, vol 64, 085005, pp. 1-17. DOI: 10.1088/1361-6560/aaff20

Author

Parisi, Alessio; Chiriotti Alvarez, Sabina; De Saint-Hubert, Marijke; Van Hoey, Olivier; Vandevoorde, Charlot; Beukes, Philip; de Kock, Evan Alexander; Symons, Julyan; Nieto-Camero, Jaime; Slabbert, Jacobus; Mégret, Patrice; Debrot, Emily; Bolst, David; Rosenfeld, Anatoly; Vanhavere, Filip / A novel methodology to assess linear energy transfer and relative biological effectiveness in proton therapy using pairs of differently doped thermoluminescent detectors.

In: Physics in Medicine and Biology, Vol. 64, 085005, 05.04.2019, p. 1-17.

Research output: Contribution to journalArticle

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@article{399982a1dab4463fa49ff3826fbba1c7,
title = "A novel methodology to assess linear energy transfer and relative biological effectiveness in proton therapy using pairs of differently doped thermoluminescent detectors",
keywords = "proton therapy, RBE, LET, microdosimetry, thermoluminescent detectors, PHITS, GEANT4",
author = "Alessio Parisi and {Chiriotti Alvarez}, Sabina and {De Saint-Hubert}, Marijke and {Van Hoey}, Olivier and Charlot Vandevoorde and Philip Beukes and {de Kock}, {Evan Alexander} and Julyan Symons and Jaime Nieto-Camero and Jacobus Slabbert and Patrice Mégret and Emily Debrot and David Bolst and Anatoly Rosenfeld and Filip Vanhavere",
note = "Score=10",
year = "2019",
month = "4",
doi = "10.1088/1361-6560/aaff20",
volume = "64",
pages = "1--17",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP - IOP Publishing",

}

RIS - Download

TY - JOUR

T1 - A novel methodology to assess linear energy transfer and relative biological effectiveness in proton therapy using pairs of differently doped thermoluminescent detectors

AU - Parisi,Alessio

AU - Chiriotti Alvarez,Sabina

AU - De Saint-Hubert,Marijke

AU - Van Hoey,Olivier

AU - Vandevoorde,Charlot

AU - Beukes,Philip

AU - de Kock,Evan Alexander

AU - Symons,Julyan

AU - Nieto-Camero,Jaime

AU - Slabbert,Jacobus

AU - Mégret,Patrice

AU - Debrot,Emily

AU - Bolst,David

AU - Rosenfeld,Anatoly

AU - Vanhavere,Filip

N1 - Score=10

PY - 2019/4/5

Y1 - 2019/4/5

N2 - A new methodology for assessing linear energy transfer (LET) and relative biological effectiveness (RBE) in proton therapy beams using thermoluminescent detectors is presented. The method is based on the different LET response of two different lithium fluoride thermoluminescent detectors (LiF:Mg,Ti and LiF:Mg,Cu,P) for measuring charged particles. The relative efficiency of the two detector types was predicted using the recently developed Microdosimetric d(z) Model in combination with the Monte Carlo code PHITS. Afterwards, the calculated ratio of the expected response of the two detector types was correlated with the fluence- and dose- mean values of the unrestricted proton LET. Using the obtained proton dose mean LET as input, the RBE was assessed using a phenomenological biophysical model of cell survival. The aforementioned methodology was benchmarked by exposing the detectors at different depths within the spread out Bragg peak (SOBP) of a clinical proton beam at iThemba LABS. The assessed LET values were found to be in good agreement with the results of radiation transport computer simulations performed using the Monte Carlo code GEANT4. Furthermore, the estimated RBE values were compared with the RBE values experimentally determined by performing colony survival measurements with Chinese Hamster Ovary (CHO) cells during the same experimental run. A very good agreement was found between the results of the proposed methodology and the results of the in vitro study.

AB - A new methodology for assessing linear energy transfer (LET) and relative biological effectiveness (RBE) in proton therapy beams using thermoluminescent detectors is presented. The method is based on the different LET response of two different lithium fluoride thermoluminescent detectors (LiF:Mg,Ti and LiF:Mg,Cu,P) for measuring charged particles. The relative efficiency of the two detector types was predicted using the recently developed Microdosimetric d(z) Model in combination with the Monte Carlo code PHITS. Afterwards, the calculated ratio of the expected response of the two detector types was correlated with the fluence- and dose- mean values of the unrestricted proton LET. Using the obtained proton dose mean LET as input, the RBE was assessed using a phenomenological biophysical model of cell survival. The aforementioned methodology was benchmarked by exposing the detectors at different depths within the spread out Bragg peak (SOBP) of a clinical proton beam at iThemba LABS. The assessed LET values were found to be in good agreement with the results of radiation transport computer simulations performed using the Monte Carlo code GEANT4. Furthermore, the estimated RBE values were compared with the RBE values experimentally determined by performing colony survival measurements with Chinese Hamster Ovary (CHO) cells during the same experimental run. A very good agreement was found between the results of the proposed methodology and the results of the in vitro study.

KW - proton therapy

KW - RBE

KW - LET

KW - microdosimetry

KW - thermoluminescent detectors

KW - PHITS

KW - GEANT4

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/33503030

U2 - 10.1088/1361-6560/aaff20

DO - 10.1088/1361-6560/aaff20

M3 - Article

VL - 64

SP - 1

EP - 17

JO - Physics in Medicine and Biology

T2 - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

M1 - 085005

ER -

ID: 5034920