A simulation framework for pre-clinical studies on dose and image quality: concept and first validation

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The purposes of the study were to set-up and validate a simulation framework for dose and image quality optimization studies. In a first phase we have evaluated whether CDRAD images as obtained with computed radiography plates could be simulated. The Monte Carlo method is a numerical method that can be used to simulate radiation transport. It is in diagnostic radiology often used in dosimetry, but in present study it is used to simulate X-ray images. With the Monte Carlo software, MCNPX, the successive steps in the imaging chain were simulated: the X-ray beam, the attenuation and scatter process in a test object and image generation by an ideal detector. Those simulated images were further modified for specific properties of CR imaging systems. To account for resolution properties the simulated images were convolved with the point spread function of the CR systems. In a last phase, noise, based on noise power spectrum (NPS) measurements, was added to the image. In this study, we simulated X-ray images of the CDRAD contrast-detail phantom. Those simulated images, modified for the CR-system, were compared with real X-ray images of the CDRAD phantom. All images were scored by computer readings.


Original languageEnglish
Title of host publicationMedical Imaging 2008: Physics of Medical Imaging
Place of PublicationBellingham, WA, United States
Publication statusPublished - 18 Mar 2008
Event2008 - MI08 - SPIE Medical Imaging: The international society for optics and photonics - Town & Country Resort and Convention Center, San Diego, CA, United States
Duration: 16 Feb 200821 Feb 2008

Publication series

NameProceedings of SPIE


Conference2008 - MI08 - SPIE Medical Imaging
Country/TerritoryUnited States
CitySan Diego, CA


  • Simulation, Monte Carlo, image quality, contrast-detail

ID: 92613