Age-related effects of X-ray irradiation on mouse hippocampus.

Research output: Contribution to journalArticle

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Age-related effects of X-ray irradiation on mouse hippocampus. / Benotmane, Rafi; Casciati, Arianna; Dobos, Katalin; Antonelli, Francesca; Benedek, Anett; Kempf, Stefan J.; Bell�s, Montserrat; Balogh, Andrea; Tanori, Mirella; Heredia, Luis; Atkinson, Michael J.; Toerne, Christine von; Azimzadeh, Omid; Saran, Anna; Safrany, Geza; Linares-Vidal, M. Victoria; Tapio, Soile; Lumniczky, Katalin; Pazzaglia, Simonetta; Quintens, Roel (Peer reviewer); Baatout, Sarah (Peer reviewer).

In: Oncotarget - Impact Journals, Vol. 7, No. 19, 28040, 10.05.2016.

Research output: Contribution to journalArticle

Harvard

Benotmane, R, Casciati, A, Dobos, K, Antonelli, F, Benedek, A, Kempf, SJ, Bell�s, M, Balogh, A, Tanori, M, Heredia, L, Atkinson, MJ, Toerne, CV, Azimzadeh, O, Saran, A, Safrany, G, Linares-Vidal, MV, Tapio, S, Lumniczky, K, Pazzaglia, S, Quintens, R & Baatout, S 2016, 'Age-related effects of X-ray irradiation on mouse hippocampus.', Oncotarget - Impact Journals, vol. 7, no. 19, 28040. https://doi.org/10.18632/oncotarget.8575

APA

Benotmane, R., Casciati, A., Dobos, K., Antonelli, F., Benedek, A., Kempf, S. J., ... Baatout, S. (2016). Age-related effects of X-ray irradiation on mouse hippocampus. Oncotarget - Impact Journals, 7(19), [28040]. https://doi.org/10.18632/oncotarget.8575

Vancouver

Benotmane R, Casciati A, Dobos K, Antonelli F, Benedek A, Kempf SJ et al. Age-related effects of X-ray irradiation on mouse hippocampus. Oncotarget - Impact Journals. 2016 May 10;7(19). 28040. https://doi.org/10.18632/oncotarget.8575

Author

Benotmane, Rafi ; Casciati, Arianna ; Dobos, Katalin ; Antonelli, Francesca ; Benedek, Anett ; Kempf, Stefan J. ; Bell�s, Montserrat ; Balogh, Andrea ; Tanori, Mirella ; Heredia, Luis ; Atkinson, Michael J. ; Toerne, Christine von ; Azimzadeh, Omid ; Saran, Anna ; Safrany, Geza ; Linares-Vidal, M. Victoria ; Tapio, Soile ; Lumniczky, Katalin ; Pazzaglia, Simonetta ; Quintens, Roel ; Baatout, Sarah. / Age-related effects of X-ray irradiation on mouse hippocampus. In: Oncotarget - Impact Journals. 2016 ; Vol. 7, No. 19.

Bibtex - Download

@article{8139982458da4f5087024b35f3315545,
title = "Age-related effects of X-ray irradiation on mouse hippocampus.",
abstract = "Therapeutic irradiation of pediatric and adult patients can profoundly affect adult neurogenesis, and cognitive impairment manifests as a deficit in hippocampal-dependent functions. Age plays a major role in susceptibility to radiation, and younger children are at higher risk of cognitive decay when compared to adults. Cranial irradiation affects hippocampal neurogenesis by induction of DNA damage in neural progenitors, through the disruption of the neurogenic microenvironment, and defective integration of newborn neurons into the neuronal network. Our goal here was to assess cellular and molecular alterations induced by cranial X-ray exposure to low/moderate doses (0.1 and 2 Gy) in the hippocampus of mice irradiated at the postnatal ages of day 10 or week 10, as well as the dependency of these phenomena on age at irradiation. To this aim, changes in the cellular composition of the dentate gyrus, mitochondrial functionality, proteomic profile in the hippocampus, as well as cognitive performance were evaluated by a multidisciplinary approach. Our results suggest the induction of specific alterations in hippocampal neurogenesis, microvascular density and mitochondrial functions, depending on age at irradiation. A better understanding of how irradiation impairs hippocampal neurogenesis at low and moderate doses is crucial to minimize adverse effects of therapeutic irradiation, contributing also to radiation safety regulations.",
keywords = "Radiation, Hippocampal neurogenisis, mitochondira, proteomics, cognitive effects",
author = "Rafi Benotmane and Arianna Casciati and Katalin Dobos and Francesca Antonelli and Anett Benedek and Kempf, {Stefan J.} and Montserrat Bell�s and Andrea Balogh and Mirella Tanori and Luis Heredia and Atkinson, {Michael J.} and Toerne, {Christine von} and Omid Azimzadeh and Anna Saran and Geza Safrany and Linares-Vidal, {M. Victoria} and Soile Tapio and Katalin Lumniczky and Simonetta Pazzaglia and Roel Quintens and Sarah Baatout",
note = "Score=10",
year = "2016",
month = "5",
day = "10",
doi = "10.18632/oncotarget.8575",
language = "English",
volume = "7",
journal = "Oncotarget - Impact Journals",
issn = "1949-2553",
publisher = "Impact Journals",
number = "19",

}

RIS - Download

TY - JOUR

T1 - Age-related effects of X-ray irradiation on mouse hippocampus.

AU - Benotmane, Rafi

AU - Casciati, Arianna

AU - Dobos, Katalin

AU - Antonelli, Francesca

AU - Benedek, Anett

AU - Kempf, Stefan J.

AU - Bell�s, Montserrat

AU - Balogh, Andrea

AU - Tanori, Mirella

AU - Heredia, Luis

AU - Atkinson, Michael J.

AU - Toerne, Christine von

AU - Azimzadeh, Omid

AU - Saran, Anna

AU - Safrany, Geza

AU - Linares-Vidal, M. Victoria

AU - Tapio, Soile

AU - Lumniczky, Katalin

AU - Pazzaglia, Simonetta

A2 - Quintens, Roel

A2 - Baatout, Sarah

N1 - Score=10

PY - 2016/5/10

Y1 - 2016/5/10

N2 - Therapeutic irradiation of pediatric and adult patients can profoundly affect adult neurogenesis, and cognitive impairment manifests as a deficit in hippocampal-dependent functions. Age plays a major role in susceptibility to radiation, and younger children are at higher risk of cognitive decay when compared to adults. Cranial irradiation affects hippocampal neurogenesis by induction of DNA damage in neural progenitors, through the disruption of the neurogenic microenvironment, and defective integration of newborn neurons into the neuronal network. Our goal here was to assess cellular and molecular alterations induced by cranial X-ray exposure to low/moderate doses (0.1 and 2 Gy) in the hippocampus of mice irradiated at the postnatal ages of day 10 or week 10, as well as the dependency of these phenomena on age at irradiation. To this aim, changes in the cellular composition of the dentate gyrus, mitochondrial functionality, proteomic profile in the hippocampus, as well as cognitive performance were evaluated by a multidisciplinary approach. Our results suggest the induction of specific alterations in hippocampal neurogenesis, microvascular density and mitochondrial functions, depending on age at irradiation. A better understanding of how irradiation impairs hippocampal neurogenesis at low and moderate doses is crucial to minimize adverse effects of therapeutic irradiation, contributing also to radiation safety regulations.

AB - Therapeutic irradiation of pediatric and adult patients can profoundly affect adult neurogenesis, and cognitive impairment manifests as a deficit in hippocampal-dependent functions. Age plays a major role in susceptibility to radiation, and younger children are at higher risk of cognitive decay when compared to adults. Cranial irradiation affects hippocampal neurogenesis by induction of DNA damage in neural progenitors, through the disruption of the neurogenic microenvironment, and defective integration of newborn neurons into the neuronal network. Our goal here was to assess cellular and molecular alterations induced by cranial X-ray exposure to low/moderate doses (0.1 and 2 Gy) in the hippocampus of mice irradiated at the postnatal ages of day 10 or week 10, as well as the dependency of these phenomena on age at irradiation. To this aim, changes in the cellular composition of the dentate gyrus, mitochondrial functionality, proteomic profile in the hippocampus, as well as cognitive performance were evaluated by a multidisciplinary approach. Our results suggest the induction of specific alterations in hippocampal neurogenesis, microvascular density and mitochondrial functions, depending on age at irradiation. A better understanding of how irradiation impairs hippocampal neurogenesis at low and moderate doses is crucial to minimize adverse effects of therapeutic irradiation, contributing also to radiation safety regulations.

KW - Radiation

KW - Hippocampal neurogenisis

KW - mitochondira

KW - proteomics

KW - cognitive effects

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/20238965

U2 - 10.18632/oncotarget.8575

DO - 10.18632/oncotarget.8575

M3 - Article

VL - 7

JO - Oncotarget - Impact Journals

JF - Oncotarget - Impact Journals

SN - 1949-2553

IS - 19

M1 - 28040

ER -

ID: 1637600