Antioxidants: A new approach to tackle radiation-induced cancers

Research output: Contribution to report/book/conference proceedingsChapterpeer-review

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Antioxidants: A new approach to tackle radiation-induced cancers. / Derradji, Hanane; Abouelaradat, Khalil; Aerts, An; Faraj Akram, Kharman; Baatout, Sarah; Harakeh, Steeve.

HERBAL MEDICINE: A Cancer Chemopreventive and Therapeutic perspective. 1. ed. New delhi, India : Jaypee Brothers Medical Publishers, 2009. p. 441-472.

Research output: Contribution to report/book/conference proceedingsChapterpeer-review

Harvard

Derradji, H, Abouelaradat, K, Aerts, A, Faraj Akram, K, Baatout, S & Harakeh, S 2009, Antioxidants: A new approach to tackle radiation-induced cancers. in HERBAL MEDICINE: A Cancer Chemopreventive and Therapeutic perspective. 1 edn, Jaypee Brothers Medical Publishers, New delhi, India, pp. 441-472.

APA

Derradji, H., Abouelaradat, K., Aerts, A., Faraj Akram, K., Baatout, S., & Harakeh, S. (2009). Antioxidants: A new approach to tackle radiation-induced cancers. In HERBAL MEDICINE: A Cancer Chemopreventive and Therapeutic perspective (1 ed., pp. 441-472). Jaypee Brothers Medical Publishers.

Vancouver

Derradji H, Abouelaradat K, Aerts A, Faraj Akram K, Baatout S, Harakeh S. Antioxidants: A new approach to tackle radiation-induced cancers. In HERBAL MEDICINE: A Cancer Chemopreventive and Therapeutic perspective. 1 ed. New delhi, India: Jaypee Brothers Medical Publishers. 2009. p. 441-472

Author

Derradji, Hanane ; Abouelaradat, Khalil ; Aerts, An ; Faraj Akram, Kharman ; Baatout, Sarah ; Harakeh, Steeve. / Antioxidants: A new approach to tackle radiation-induced cancers. HERBAL MEDICINE: A Cancer Chemopreventive and Therapeutic perspective. 1. ed. New delhi, India : Jaypee Brothers Medical Publishers, 2009. pp. 441-472

Bibtex - Download

@inbook{b1a260e5b7ca4e07867484e648c7eb14,
title = "Antioxidants: A new approach to tackle radiation-induced cancers",
abstract = "Radiation results in the generation of reactive oxygen species (ROS) or free radicals which are likely to cause damaging effects to DNA, lipid membranes and other structures in their vicinity. If such damage is not repaired, it may lead to mutations and carcinogenesis. The denaturation of proteins and the peroxidation of lipids have a deleterious effect on enzymes causing their activity to be compromised. Radiation causes different types of DNA damage, including single-strand breaks and DNA–protein cross-links. The body has natural defenses against oxidative stress including antioxidant enzymes, particularly superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, thioredoxin reductase and NAD(P)H:quinone reductase. There are also intrinsic non-enzymatic antioxidants, notably glutathione and ascorbic acid (vitamin C) in the aqueous phase, and tocopherols (vitamin E) in the lipid phase. Therefore, supplementing the body with antioxidants provides a protective mechanism against ROS. This review focuses on the effects of carotenoids, vitamin C, vitamin E, selenium, flavonoids and other antioxidants on radiation-induced cancers. In addition, the effects of mixtures of antioxidants and a number of other agents showing antioxidant properties will also be discussed. These include a range of plant antioxidants including green tea polyphenols, curcumin, and other carotenoids such as lutein and lycopene.",
keywords = "antioxidants, radiation-induced cancer, free radicals, reactive oxygen species",
author = "Hanane Derradji and Khalil Abouelaradat and An Aerts and {Faraj Akram}, Kharman and Sarah Baatout and Steeve Harakeh",
note = "Score = 3",
year = "2009",
month = nov,
day = "26",
language = "English",
isbn = "978-81-8448-841-8",
pages = "441--472",
booktitle = "HERBAL MEDICINE: A Cancer Chemopreventive and Therapeutic perspective",
publisher = "Jaypee Brothers Medical Publishers",
edition = "1",

}

RIS - Download

TY - CHAP

T1 - Antioxidants: A new approach to tackle radiation-induced cancers

AU - Derradji, Hanane

AU - Abouelaradat, Khalil

AU - Aerts, An

AU - Faraj Akram, Kharman

AU - Baatout, Sarah

AU - Harakeh, Steeve

N1 - Score = 3

PY - 2009/11/26

Y1 - 2009/11/26

N2 - Radiation results in the generation of reactive oxygen species (ROS) or free radicals which are likely to cause damaging effects to DNA, lipid membranes and other structures in their vicinity. If such damage is not repaired, it may lead to mutations and carcinogenesis. The denaturation of proteins and the peroxidation of lipids have a deleterious effect on enzymes causing their activity to be compromised. Radiation causes different types of DNA damage, including single-strand breaks and DNA–protein cross-links. The body has natural defenses against oxidative stress including antioxidant enzymes, particularly superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, thioredoxin reductase and NAD(P)H:quinone reductase. There are also intrinsic non-enzymatic antioxidants, notably glutathione and ascorbic acid (vitamin C) in the aqueous phase, and tocopherols (vitamin E) in the lipid phase. Therefore, supplementing the body with antioxidants provides a protective mechanism against ROS. This review focuses on the effects of carotenoids, vitamin C, vitamin E, selenium, flavonoids and other antioxidants on radiation-induced cancers. In addition, the effects of mixtures of antioxidants and a number of other agents showing antioxidant properties will also be discussed. These include a range of plant antioxidants including green tea polyphenols, curcumin, and other carotenoids such as lutein and lycopene.

AB - Radiation results in the generation of reactive oxygen species (ROS) or free radicals which are likely to cause damaging effects to DNA, lipid membranes and other structures in their vicinity. If such damage is not repaired, it may lead to mutations and carcinogenesis. The denaturation of proteins and the peroxidation of lipids have a deleterious effect on enzymes causing their activity to be compromised. Radiation causes different types of DNA damage, including single-strand breaks and DNA–protein cross-links. The body has natural defenses against oxidative stress including antioxidant enzymes, particularly superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, thioredoxin reductase and NAD(P)H:quinone reductase. There are also intrinsic non-enzymatic antioxidants, notably glutathione and ascorbic acid (vitamin C) in the aqueous phase, and tocopherols (vitamin E) in the lipid phase. Therefore, supplementing the body with antioxidants provides a protective mechanism against ROS. This review focuses on the effects of carotenoids, vitamin C, vitamin E, selenium, flavonoids and other antioxidants on radiation-induced cancers. In addition, the effects of mixtures of antioxidants and a number of other agents showing antioxidant properties will also be discussed. These include a range of plant antioxidants including green tea polyphenols, curcumin, and other carotenoids such as lutein and lycopene.

KW - antioxidants

KW - radiation-induced cancer

KW - free radicals

KW - reactive oxygen species

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_101290

UR - http://knowledgecentre.sckcen.be/so2/bibref/6239

M3 - Chapter

SN - 978-81-8448-841-8

SP - 441

EP - 472

BT - HERBAL MEDICINE: A Cancer Chemopreventive and Therapeutic perspective

PB - Jaypee Brothers Medical Publishers

CY - New delhi, India

ER -

ID: 132944