Assessing Organ Doses from Paediatric CT Scans—A Novel Approach for an Epidemiology Study

Research output: Contribution to journalArticle

Authors

  • Isabelle Thierry-Chef
  • Jérémie Dabin
  • Eva Friberg
  • Johannes Hermen
  • Tore Istad
  • Andreas Jahnen
  • Lucian Krille
  • Choonsik Lee
  • Carlo Maccia
  • Arvid Nordenskjöld
  • Hilde Olerud
  • Kaddour Rani
  • Jean-Luc Rehel
  • Steven Simon
  • Lara Struelens
  • Ausrele Kesminiene

Institutes & Expert groups

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Abstract

The increasing worldwide use of paediatric computed tomography (CT) has led to increasing concerns regarding the subsequent effects of exposure to radiation. In response to this concern, the international EPI-CT project was developed to study the risk of cancer in a large multi-country cohort. In radiation epidemiology, accurate estimates of organ-specific doses are essential. In EPI-CT, data collection is split into two time periods—before and after introduction of the Picture Archiving Communication System (PACS) introduced in the 1990s. Prior to PACS, only sparse information about scanner settings is available from radiology departments. Hence, a multi-level approach was developed to retrieve information from a questionnaire, surveys, scientific publications, and expert interviews. For the years after PACS was introduced, scanner settings will be extracted from Digital Imaging and Communications in Medicine (DICOM) headers, a protocol for storing medical imaging data. Radiation fields and X-ray interactions within the body will be simulated using phantoms of various ages and Monte-Carlo-based radiation transport calculations. Individual organ doses will be estimated for each child using an accepted calculation strategy, scanner settings, and the radiation transport calculations. Comprehensive analyses of missing and uncertain dosimetry data will be conducted to provide uncertainty distributions of doses.

Details

Original languageEnglish
Pages (from-to)717-728
JournalInternational Journal of Environmental Research and Public Health
Volume10
Issue number2
DOIs
Publication statusPublished - 18 Feb 2013

Keywords

  • paediatric computed tomography, organ dose reconstruction, scanner settings, leukaemia, cancer risk

ID: 205410