Research output: Contribution to journal › Article › peer-review
Assessing the Impact of Flavophospholipol and Virginiamycin Supplementation on the Broiler Microbiota - a Prospective Controlled Intervention Study. / Ahmed, Mohamed; Berkell, Matilda; Xavier, Britto; De Backer, Sarah; Lammens, Christine; Hautekiet, Veerle.
In: mSystems, Vol. 6, No. 4, e00381-21, 31.08.2021, p. 1-16.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Assessing the Impact of Flavophospholipol and Virginiamycin Supplementation on the Broiler Microbiota - a Prospective Controlled Intervention Study
AU - Ahmed, Mohamed
AU - Berkell, Matilda
AU - Xavier, Britto
AU - De Backer, Sarah
AU - Lammens, Christine
AU - Hautekiet, Veerle
N1 - Score=10
PY - 2021/8/31
Y1 - 2021/8/31
N2 - The antibiotic growth promoters (AGPs) flavophospholipol and virginiamycin have been widely used for decades in food animal production. AGP activity is believed to be partly modulated by gut microbial composition although exact AGPinduced changes remain unclear. In a controlled intervention study, we studied the effect of flavophospholipol and virginiamycin on the broiler chicken ileal microbiota spanning from birth to 39 days. Using 16S rRNA gene profiling and prediction of metabolic activity, we show that both AGPs result in dynamic microbial shifts that potentially increase anti-inflammatory mechanisms and bioavailability of several essential nutrients by decreasing degradation (flavophospholipol) or increasing biosynthesis (virginiamycin). Further, virginiamycin-supplemented broilers showed increased colonization with potentially pathogenic bacteria, Clostridium perfringens, Campylobacter, and Escherichia/Shigella spp. Overall, we show that both AGPs induce microbial changes potentially beneficial for growth. However, the increase in (foodborne) pathogens shown here with virginiamycin use could impact not only broiler mortality but also human health.
AB - The antibiotic growth promoters (AGPs) flavophospholipol and virginiamycin have been widely used for decades in food animal production. AGP activity is believed to be partly modulated by gut microbial composition although exact AGPinduced changes remain unclear. In a controlled intervention study, we studied the effect of flavophospholipol and virginiamycin on the broiler chicken ileal microbiota spanning from birth to 39 days. Using 16S rRNA gene profiling and prediction of metabolic activity, we show that both AGPs result in dynamic microbial shifts that potentially increase anti-inflammatory mechanisms and bioavailability of several essential nutrients by decreasing degradation (flavophospholipol) or increasing biosynthesis (virginiamycin). Further, virginiamycin-supplemented broilers showed increased colonization with potentially pathogenic bacteria, Clostridium perfringens, Campylobacter, and Escherichia/Shigella spp. Overall, we show that both AGPs induce microbial changes potentially beneficial for growth. However, the increase in (foodborne) pathogens shown here with virginiamycin use could impact not only broiler mortality but also human health.
KW - Flavomycin
KW - Flavophospholipol
KW - Virginiamycin
KW - Broiler chicken
KW - Microbiota
KW - 16S rRNA sequencing
UR - https://ecm.sckcen.be/OTCS/llisapi.dll/open/45205771
U2 - 10.1128/mSystems.00381-21
DO - 10.1128/mSystems.00381-21
M3 - Article
VL - 6
SP - 1
EP - 16
JO - mSystems
JF - mSystems
SN - 2379-5077
IS - 4
M1 - e00381-21
ER -
ID: 7185441