Assessment of Radiosensitivity and Monitoring of Radiation-Induced Cellular Damage

Research output: Contribution to report/book/conference proceedingsChapter

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Assessment of Radiosensitivity and Monitoring of Radiation-Induced Cellular Damage. / Moreels, Marjan; Quintens, Roel; Baatout, Sarah.

Stress Challenges and Immunity in Space. 1. ed. Berlin-Heidelberg, Germany : Springer, 2012. p. 345-356.

Research output: Contribution to report/book/conference proceedingsChapter

Harvard

Moreels, M, Quintens, R & Baatout, S 2012, Assessment of Radiosensitivity and Monitoring of Radiation-Induced Cellular Damage. in Stress Challenges and Immunity in Space. 1 edn, Springer, Berlin-Heidelberg, Germany, pp. 345-356.

APA

Moreels, M., Quintens, R., & Baatout, S. (2012). Assessment of Radiosensitivity and Monitoring of Radiation-Induced Cellular Damage. In Stress Challenges and Immunity in Space (1 ed., pp. 345-356). Berlin-Heidelberg, Germany: Springer.

Vancouver

Moreels M, Quintens R, Baatout S. Assessment of Radiosensitivity and Monitoring of Radiation-Induced Cellular Damage. In Stress Challenges and Immunity in Space. 1 ed. Berlin-Heidelberg, Germany: Springer. 2012. p. 345-356

Author

Moreels, Marjan ; Quintens, Roel ; Baatout, Sarah. / Assessment of Radiosensitivity and Monitoring of Radiation-Induced Cellular Damage. Stress Challenges and Immunity in Space. 1. ed. Berlin-Heidelberg, Germany : Springer, 2012. pp. 345-356

Bibtex - Download

@inbook{f908765281674c1ab9b68004786b5f1a,
title = "Assessment of Radiosensitivity and Monitoring of Radiation-Induced Cellular Damage",
abstract = "In contrast to individuals on Earth, astronauts receive much higher doses of ionizing radiation during spaceflight. Besides this, the type of radiation in space is quite different from terrestrial radiation, and consists mainly of high-energy protons and highly charged and energetic particles. It is well known that all types of ionizing radiation induce a large spectrum of DNA lesions and the global response of a cell to DNA damage triggers multiple pathways involved in sensing DNA damage, activating cell cycle checkpoints and inducing DNA repair. However, when damage is severe, apoptosis, also known as “programmed cell death”, can be induced. Ionizing radiation exposure induces biological effects, depending on the type of radiation, dose, and exposure time. In this context, radiation dosimetry on board spacecraft can be useful to estimate the cumulative equivalent doses to which astronauts are exposed. So far, the precise impact of radiation on the deterioration of the immune system in astronauts is still under investigation. Several ground-based experiments on various radiation facilities have been performed and have contributed to our general knowledge of radiation-induced immune changes. Crucially, radiation interacts with other spaceflight stressors, such as microgravity, thereby resulting in a joint effect on the immune system.",
keywords = "cosmic radiation, DNA damage, immune system impairment, ground based experiments",
author = "Marjan Moreels and Roel Quintens and Sarah Baatout",
note = "Score = 3",
year = "2012",
month = "1",
language = "English",
isbn = "978-3-642-22271-9",
pages = "345--356",
booktitle = "Stress Challenges and Immunity in Space",
publisher = "Springer",
edition = "1",

}

RIS - Download

TY - CHAP

T1 - Assessment of Radiosensitivity and Monitoring of Radiation-Induced Cellular Damage

AU - Moreels, Marjan

AU - Quintens, Roel

AU - Baatout, Sarah

N1 - Score = 3

PY - 2012/1

Y1 - 2012/1

N2 - In contrast to individuals on Earth, astronauts receive much higher doses of ionizing radiation during spaceflight. Besides this, the type of radiation in space is quite different from terrestrial radiation, and consists mainly of high-energy protons and highly charged and energetic particles. It is well known that all types of ionizing radiation induce a large spectrum of DNA lesions and the global response of a cell to DNA damage triggers multiple pathways involved in sensing DNA damage, activating cell cycle checkpoints and inducing DNA repair. However, when damage is severe, apoptosis, also known as “programmed cell death”, can be induced. Ionizing radiation exposure induces biological effects, depending on the type of radiation, dose, and exposure time. In this context, radiation dosimetry on board spacecraft can be useful to estimate the cumulative equivalent doses to which astronauts are exposed. So far, the precise impact of radiation on the deterioration of the immune system in astronauts is still under investigation. Several ground-based experiments on various radiation facilities have been performed and have contributed to our general knowledge of radiation-induced immune changes. Crucially, radiation interacts with other spaceflight stressors, such as microgravity, thereby resulting in a joint effect on the immune system.

AB - In contrast to individuals on Earth, astronauts receive much higher doses of ionizing radiation during spaceflight. Besides this, the type of radiation in space is quite different from terrestrial radiation, and consists mainly of high-energy protons and highly charged and energetic particles. It is well known that all types of ionizing radiation induce a large spectrum of DNA lesions and the global response of a cell to DNA damage triggers multiple pathways involved in sensing DNA damage, activating cell cycle checkpoints and inducing DNA repair. However, when damage is severe, apoptosis, also known as “programmed cell death”, can be induced. Ionizing radiation exposure induces biological effects, depending on the type of radiation, dose, and exposure time. In this context, radiation dosimetry on board spacecraft can be useful to estimate the cumulative equivalent doses to which astronauts are exposed. So far, the precise impact of radiation on the deterioration of the immune system in astronauts is still under investigation. Several ground-based experiments on various radiation facilities have been performed and have contributed to our general knowledge of radiation-induced immune changes. Crucially, radiation interacts with other spaceflight stressors, such as microgravity, thereby resulting in a joint effect on the immune system.

KW - cosmic radiation

KW - DNA damage

KW - immune system impairment

KW - ground based experiments

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_118372

UR - http://knowledgecentre.sckcen.be/so2/bibref/8743

M3 - Chapter

SN - 978-3-642-22271-9

SP - 345

EP - 356

BT - Stress Challenges and Immunity in Space

PB - Springer

CY - Berlin-Heidelberg, Germany

ER -

ID: 239895