Call to arms: need for radiobiology in molecular radionuclide therapy

Research output: Contribution to journalArticlepeer-review


  • Samantha Y.A. Terry
  • Julie Nonnekens
  • An Aerts
  • Sarah Baatout
  • Marion de Jong
  • Bart Cornelissen
  • Jean-Pierre Pouget

Institutes & Expert groups

  • KCL - King’s College London - Department of Imaging Chemistry and Biology, School of Biomedical Engineering & Imaging Sciences
  • Erasmus MC
  • University of Oxford
  • Inserm - French National Institute of Health and Medical Research
  • University of Montpellier 2 - Sciences et Techniques
  • ICM - Institut régional du Cancer Montpellier
  • CRUK/MRC Oxford Institute for Radiation Oncology, Department of OncologyUniversity of Oxford

Documents & links


Dear Sir, Now is an extraordinarily exciting time for the multidisciplinary field of molecular radionuclide therapy (MRT) [1, 2, 3]. More patients than ever before are being treated with radiolabelled compounds, and an increasing number of pharmaceutical companies incorporate radiopharmaceuticals into their portfolios. MRT allows specific irradiation of localised and disseminated disease, with potentially fewer side effects than external beam radiotherapy (EBRT). However, aside from obvious improvements in radiochemistry, radiopharmacy, and dosimetry of MRT agents, a better understanding of the radiobiology, i.e. of the biological effects of ionising radiation of MRT agents, is needed. Radiobiology has been key in establishing optimal treatment regimens for EBRT whilst protecting healthy tissues. The paradigm of radiobiology is that tumour control probability and side effects are proportional to absorbed radiation dose; radiobiology is thus deeply connected with dosimetry. However,...


Original languageEnglish
Pages (from-to)1588-1590
Number of pages3
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number8
Publication statusPublished - 8 May 2019


  • radiopharmaceutical, radionuclide radiotherapy, nuclear medicine, individual sensitivity, healthy tissue effects

ID: 5209973