Cancer Studies under Space Conditions: Finding Answers Abroad

Research output: Contribution to journalArticlepeer-review

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Cancer Studies under Space Conditions: Finding Answers Abroad. / Cortés-Sánchez, José Luis; Callant, Jonas; Krüger, Marcus; Sahana, Jayashree; Kraus, Armin; Baselet, Bjorn; Infanger, Manfred; Baatout, Sarah; Grimm, Daniela.

In: Biomedicines, Vol. 10, No. 25, 10010025, 2022, p. 1-28.

Research output: Contribution to journalArticlepeer-review

Harvard

Cortés-Sánchez, JL, Callant, J, Krüger, M, Sahana, J, Kraus, A, Baselet, B, Infanger, M, Baatout, S & Grimm, D 2022, 'Cancer Studies under Space Conditions: Finding Answers Abroad', Biomedicines, vol. 10, no. 25, 10010025, pp. 1-28. https://doi.org/10.3390/ biomedicines10010025

APA

Cortés-Sánchez, J. L., Callant, J., Krüger, M., Sahana, J., Kraus, A., Baselet, B., Infanger, M., Baatout, S., & Grimm, D. (2022). Cancer Studies under Space Conditions: Finding Answers Abroad. Biomedicines, 10(25), 1-28. [10010025]. https://doi.org/10.3390/ biomedicines10010025

Vancouver

Cortés-Sánchez JL, Callant J, Krüger M, Sahana J, Kraus A, Baselet B et al. Cancer Studies under Space Conditions: Finding Answers Abroad. Biomedicines. 2022;10(25):1-28. 10010025. https://doi.org/10.3390/ biomedicines10010025

Author

Cortés-Sánchez, José Luis ; Callant, Jonas ; Krüger, Marcus ; Sahana, Jayashree ; Kraus, Armin ; Baselet, Bjorn ; Infanger, Manfred ; Baatout, Sarah ; Grimm, Daniela. / Cancer Studies under Space Conditions: Finding Answers Abroad. In: Biomedicines. 2022 ; Vol. 10, No. 25. pp. 1-28.

Bibtex - Download

@article{01668aa46a094551859dc1d6ae39a416,
title = "Cancer Studies under Space Conditions: Finding Answers Abroad",
abstract = "In this review article, we discuss the current state of knowledge in cancer research under real and simulated microgravity conditions and point out further research directions in this field. Outer space is an extremely hostile environment for human life, with radiation, microgravity, and vacuum posing significant hazards. Although the risk for cancer in astronauts is not clear, microgravity plays a thought-provoking role in the carcinogenesis of normal and cancer cells, causing such effects as multicellular spheroid formation, cytoskeleton rearrangement, alteration of gene expression and protein synthesis, and apoptosis. Furthermore, deleterious effects of radiation on cells seem to be accentuated under microgravity. Ground-based facilities have been used to study microgravity effects in addition to laborious experiments during parabolic flights or on space stations. Some potential {\textquoteleft}gravisensors{\textquoteright} have already been detected, and further identification of these mechanisms of mechanosensitivity could open up ways for therapeutic influence on cancer growth and apoptosis. These novel findings may help to find new effective cancer treatments and to provide health protection for humans on future long-term spaceflights and exploration of outer space.",
keywords = "Review, Gravitation, Weightlessness, Neoplasms, Gene expression, Mechanobiology, Gravisensors",
author = "Cort{\'e}s-S{\'a}nchez, {Jos{\'e} Luis} and Jonas Callant and Marcus Kr{\"u}ger and Jayashree Sahana and Armin Kraus and Bjorn Baselet and Manfred Infanger and Sarah Baatout and Daniela Grimm",
note = "Score=10",
year = "2022",
doi = "10.3390/ biomedicines10010025",
language = "English",
volume = "10",
pages = "1--28",
journal = "Biomedicines",
issn = "2227-9059",
publisher = "MDPI",
number = "25",

}

RIS - Download

TY - JOUR

T1 - Cancer Studies under Space Conditions: Finding Answers Abroad

AU - Cortés-Sánchez, José Luis

AU - Callant, Jonas

AU - Krüger, Marcus

AU - Sahana, Jayashree

AU - Kraus, Armin

AU - Baselet, Bjorn

AU - Infanger, Manfred

AU - Baatout, Sarah

AU - Grimm, Daniela

N1 - Score=10

PY - 2022

Y1 - 2022

N2 - In this review article, we discuss the current state of knowledge in cancer research under real and simulated microgravity conditions and point out further research directions in this field. Outer space is an extremely hostile environment for human life, with radiation, microgravity, and vacuum posing significant hazards. Although the risk for cancer in astronauts is not clear, microgravity plays a thought-provoking role in the carcinogenesis of normal and cancer cells, causing such effects as multicellular spheroid formation, cytoskeleton rearrangement, alteration of gene expression and protein synthesis, and apoptosis. Furthermore, deleterious effects of radiation on cells seem to be accentuated under microgravity. Ground-based facilities have been used to study microgravity effects in addition to laborious experiments during parabolic flights or on space stations. Some potential ‘gravisensors’ have already been detected, and further identification of these mechanisms of mechanosensitivity could open up ways for therapeutic influence on cancer growth and apoptosis. These novel findings may help to find new effective cancer treatments and to provide health protection for humans on future long-term spaceflights and exploration of outer space.

AB - In this review article, we discuss the current state of knowledge in cancer research under real and simulated microgravity conditions and point out further research directions in this field. Outer space is an extremely hostile environment for human life, with radiation, microgravity, and vacuum posing significant hazards. Although the risk for cancer in astronauts is not clear, microgravity plays a thought-provoking role in the carcinogenesis of normal and cancer cells, causing such effects as multicellular spheroid formation, cytoskeleton rearrangement, alteration of gene expression and protein synthesis, and apoptosis. Furthermore, deleterious effects of radiation on cells seem to be accentuated under microgravity. Ground-based facilities have been used to study microgravity effects in addition to laborious experiments during parabolic flights or on space stations. Some potential ‘gravisensors’ have already been detected, and further identification of these mechanisms of mechanosensitivity could open up ways for therapeutic influence on cancer growth and apoptosis. These novel findings may help to find new effective cancer treatments and to provide health protection for humans on future long-term spaceflights and exploration of outer space.

KW - Review

KW - Gravitation

KW - Weightlessness

KW - Neoplasms

KW - Gene expression

KW - Mechanobiology

KW - Gravisensors

UR - https://ecm.sckcen.be/OTCS/llisapi.dll?func=ll&objAction=download&objId=46883332

U2 - 10.3390/ biomedicines10010025

DO - 10.3390/ biomedicines10010025

M3 - Article

VL - 10

SP - 1

EP - 28

JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 25

M1 - 10010025

ER -

ID: 7321045