Carbon ion irradiation suppresses metastasis related genes in human prostate carcinoma cells

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Abstract

Hadrontherapy is a form of external radiation therapy, which uses beams of charged particles such as carbon ions. Compared to conventional X-ray therapy, the main advantage of hadrontherapy is the precise dose localization along with an increased biological effectiveness. This high ballistic accuracy allows depositing the maximal dose to the tumor, while damage to the surrounding healthy tissue is limited. First results obtained from prostate cancer patients treated with carbon ion therapy, show good local tumor control and survival rates. The impact of hadrontherapy on cancer metastasis is not yet well characterized. Previous studies have shown that hadrontherapy may inhibit metastasis by suppressing cell motility and migration. In contrast, clinical studies show evidence that X-rays might promote the metastatic potential of cancer cells. In this study we investigated the effect of carbon and X-irradiation on changes in metastasis related genes in the human prostate adenocarcinoma cell line, PC3. Our initial results demonstrate that carbon irradiation induced more strongly effects at the level of gene expression compared to similar doses of X-rays. A better understanding of the effects of different radiation qualities on the migration potential of prostate cancer cells is important for improving the clinical outcome of cancer radiation therapy.

Details

Original languageEnglish
Title of host publicationProceedings ENC 2012, European Nuclear Conference
Place of PublicationBelgium
Pages113-119
Publication statusPublished - Dec 2012
EventThe European Forum to discuss Nuclear Technology Issues, Opportunities & Challenges - ENC 2012 - Manchester, United Kingdom
Duration: 9 Dec 201212 Dec 2012

Conference

ConferenceThe European Forum to discuss Nuclear Technology Issues, Opportunities & Challenges - ENC 2012
CountryUnited Kingdom
CityManchester
Period2012-12-092012-12-12

Keywords

  • Hadrontherapy, cancer radiation therapy, carbon irradiation

ID: 273696