Cellular dosimetry of [177Lu]Lu-DOTA-[Tyr3]octreotate radionuclide therapy: the impact of modeling assumptions on the correlation with in vitro cytotoxicity

Research output: Contribution to journalArticle

Authors

Institutes & Expert groups

  • SCK•CEN - Studiecentrum voor Kernenergie/Centre d’Etude de l’Energie Nucléaire
  • Erasmus MC

Abstract

Survival and linear-quadratic model fitting parameters implemented in treatment planning for targeted radionuclide therapy depend on accurate cellular dosimetry. Therefore, we have built a refined cellular dosimetry model for [177Lu]Lu-DOTA-[Tyr3]octreotate (177Lu-DOTATATE) in vitro experiments, accounting for specific cell morphologies and sub-cellular radioactivity distributions.

Details

Original languageEnglish
Pages (from-to)1-19
Number of pages19
JournalEJNMMI Physics
Volume7
Issue number8
DOIs
Publication statusPublished - 10 Feb 2020

Keywords

  • Cellular dosimetry, [177Lu]Lu-DOTA-[Tyr3]octreotate, Polygonal mesh, S values, in vitro cytotoxicity correlation

ID: 6715303