Cellular dosimetry of [177Lu]Lu-DOTA-[Tyr3]octreotate radionuclide therapy: the impact of modeling assumptions on the correlation with in vitro cytotoxicity

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Cellular dosimetry of [177Lu]Lu-DOTA-[Tyr3]octreotate radionuclide therapy: the impact of modeling assumptions on the correlation with in vitro cytotoxicity. / Tamborino, Giulia; De Saint-Hubert, Marijke; Struelens, Lara; Seoane, Dayana C.; Ruigrok, Eline A.M.; Aerts, An; van Cappellen, Wiggert A.; de Jong, Marion; Konijnenberg, Mark W.; Nonnekens, Julie.

In: EJNMMI Physics, Vol. 7, No. 8, 10.02.2020, p. 1-19.

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Tamborino, Giulia ; De Saint-Hubert, Marijke ; Struelens, Lara ; Seoane, Dayana C. ; Ruigrok, Eline A.M. ; Aerts, An ; van Cappellen, Wiggert A. ; de Jong, Marion ; Konijnenberg, Mark W. ; Nonnekens, Julie. / Cellular dosimetry of [177Lu]Lu-DOTA-[Tyr3]octreotate radionuclide therapy: the impact of modeling assumptions on the correlation with in vitro cytotoxicity. In: EJNMMI Physics. 2020 ; Vol. 7, No. 8. pp. 1-19.

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@article{dc1a4771e79a4082b3ce3742bdbdcdd1,
title = "Cellular dosimetry of [177Lu]Lu-DOTA-[Tyr3]octreotate radionuclide therapy: the impact of modeling assumptions on the correlation with in vitro cytotoxicity",
abstract = "Survival and linear-quadratic model fitting parameters implemented in treatment planning for targeted radionuclide therapy depend on accurate cellular dosimetry. Therefore, we have built a refined cellular dosimetry model for [177Lu]Lu-DOTA-[Tyr3]octreotate (177Lu-DOTATATE) in vitro experiments, accounting for specific cell morphologies and sub-cellular radioactivity distributions.",
keywords = "Cellular dosimetry, [177Lu]Lu-DOTA-[Tyr3]octreotate, Polygonal mesh, S values, in vitro cytotoxicity correlation",
author = "Giulia Tamborino and {De Saint-Hubert}, Marijke and Lara Struelens and Seoane, {Dayana C.} and Ruigrok, {Eline A.M.} and An Aerts and {van Cappellen}, {Wiggert A.} and {de Jong}, Marion and Konijnenberg, {Mark W.} and Julie Nonnekens",
note = "Score=10",
year = "2020",
month = "2",
day = "10",
doi = "10.1186/s40658-020-0276-5",
language = "English",
volume = "7",
pages = "1--19",
journal = "EJNMMI Physics",
issn = "2197-7364",
publisher = "BMC (Part of Springer Nature)",
number = "8",

}

RIS - Download

TY - JOUR

T1 - Cellular dosimetry of [177Lu]Lu-DOTA-[Tyr3]octreotate radionuclide therapy: the impact of modeling assumptions on the correlation with in vitro cytotoxicity

AU - Tamborino, Giulia

AU - De Saint-Hubert, Marijke

AU - Struelens, Lara

AU - Seoane, Dayana C.

AU - Ruigrok, Eline A.M.

AU - Aerts, An

AU - van Cappellen, Wiggert A.

AU - de Jong, Marion

AU - Konijnenberg, Mark W.

AU - Nonnekens, Julie

N1 - Score=10

PY - 2020/2/10

Y1 - 2020/2/10

N2 - Survival and linear-quadratic model fitting parameters implemented in treatment planning for targeted radionuclide therapy depend on accurate cellular dosimetry. Therefore, we have built a refined cellular dosimetry model for [177Lu]Lu-DOTA-[Tyr3]octreotate (177Lu-DOTATATE) in vitro experiments, accounting for specific cell morphologies and sub-cellular radioactivity distributions.

AB - Survival and linear-quadratic model fitting parameters implemented in treatment planning for targeted radionuclide therapy depend on accurate cellular dosimetry. Therefore, we have built a refined cellular dosimetry model for [177Lu]Lu-DOTA-[Tyr3]octreotate (177Lu-DOTATATE) in vitro experiments, accounting for specific cell morphologies and sub-cellular radioactivity distributions.

KW - Cellular dosimetry

KW - [177Lu]Lu-DOTA-[Tyr3]octreotate

KW - Polygonal mesh

KW - S values

KW - in vitro cytotoxicity correlation

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/open/37415038

U2 - 10.1186/s40658-020-0276-5

DO - 10.1186/s40658-020-0276-5

M3 - Article

VL - 7

SP - 1

EP - 19

JO - EJNMMI Physics

JF - EJNMMI Physics

SN - 2197-7364

IS - 8

ER -

ID: 6715303