Chapter 30: Site-specific labeling of his-tagged Nanobodies with 99mTc: a practical guide
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Abstract
Chapter 30: the 99mTc-tricarbonyl chemistry provides an elegant technology to site-specifically radiolabel histidine-tagged biomolecules. Considering their unique biochemical properties, this straightforward technology is particularly suited for Nanobodies. This chapter gives a detailed guide to generate highly specific Nanobody-derived radiotracers for both in vitro binding studies and in vivo molecular imaging.
Details
| Original language | English |
|---|---|
| Title of host publication | Singe Domain Antibodies, Methods and Protocols |
| Place of Publication | Springer New York Heidelberg Dordrecht London, United States |
| Publisher | Springer |
| Pages | 485-490 |
| Edition | 1 |
| ISBN (Print) | 978-1-61779-968-6 |
| Publication status | Published - Jan 2012 |
Publication series
| Name | Methods in Molecular Biology |
|---|---|
| Number | 911 |
Keywords
- Nanobody, 99mTc
ID: 156953