Abstract
Molecular imaging is a noninvasive method to measure specific biological processes in animal models and patients using imaging. In recent years there has been a tremendous evolution in hardware and software for imaging purposes. This progress has created an urgent need for new labeled targeted molecular probes. The unique physicochemical and pharmacokinetic properties of Nanobodies match the requirements of the ideal molecular imaging tracer. Preclinical studies show strong and specific targeting in vivo with rapid
clearance of unbound probe resulting in high contrasted images at early time points after intravenous administration. These data suggest that the Nanobody platform might become a generic method for the development of next generation molecular imaging probes.
Details
Original language | English |
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Title of host publication | Singe Domain Antibodies, Methods and Protocols |
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Place of Publication | Springer New York Heidelberg Dordrecht London, United States |
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Publisher | Springer |
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Pages | 559-567 |
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Edition | 1 |
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ISBN (Print) | 978-1-61779-968-6 |
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Publication status | Published - Jan 2012 |
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Name | Methods in Molecular Biology |
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Number | 911 |
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