Combination Therapy With Charged Particles and Molecular Targeting - A Promising Avenue to Overcome Radioresistance

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Combination Therapy With Charged Particles and Molecular Targeting - A Promising Avenue to Overcome Radioresistance. / Konings, Katrien; Vandevoorde, Charlot; Baselet, Bjorn; Baatout, Sarah; Moreels, Marjan.

In: Frontiers in Oncology, Vol. 10, 128, 14.02.2020, p. 1-21.

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@article{2e5132a85ee14c20a1fcfa56222b6230,
title = "Combination Therapy With Charged Particles and Molecular Targeting - A Promising Avenue to Overcome Radioresistance",
abstract = "Radiotherapy plays a central role in the treatment of cancer patients. Over the past decades, remarkable technological progress has been made in the field of conventional radiotherapy. In addition, the use of charged particles (e.g., protons and carbon ions) makes it possible to further improve dose deposition to the tumor, while sparing the surrounding healthy tissues. Despite these improvements, radioresistance and tumor recurrence are still observed. Although the mechanisms underlying resistance to conventional radiotherapy are well-studied, scientific evidence on the impact of charged particle therapy on cancer cell radioresistance is restricted. The purpose of this review is to discuss the potential role that charged particles could play to overcome radioresistance. This review will focus on hypoxia, cancer stem cells, and specific signaling pathways of EGFR, NFkB, and Hedgehog as well as DNA damage signaling involving PARP, as mechanisms of radioresistance for which pharmacological targets have been identified. Finally, new lines of future research will be proposed, with a focus on novel molecular inhibitors that could be used in combination with charged particle therapy as a novel treatment option for radioresistant tumors.",
keywords = "Radioresistance, Radiosensitization, X-rays, Proton therapy, Particle therapy, Carbon ion therapy, Molecular targeted drugs, Combination treatment",
author = "Katrien Konings and Charlot Vandevoorde and Bjorn Baselet and Sarah Baatout and Marjan Moreels",
note = "Score=10",
year = "2020",
month = "2",
day = "14",
doi = "10.3389/fonc.2020.00128",
language = "English",
volume = "10",
pages = "1--21",
journal = "Frontiers in Oncology",
issn = "2234-943X",
publisher = "Frontiers Media SA",

}

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TY - JOUR

T1 - Combination Therapy With Charged Particles and Molecular Targeting - A Promising Avenue to Overcome Radioresistance

AU - Konings, Katrien

AU - Vandevoorde, Charlot

AU - Baselet, Bjorn

AU - Baatout, Sarah

AU - Moreels, Marjan

N1 - Score=10

PY - 2020/2/14

Y1 - 2020/2/14

N2 - Radiotherapy plays a central role in the treatment of cancer patients. Over the past decades, remarkable technological progress has been made in the field of conventional radiotherapy. In addition, the use of charged particles (e.g., protons and carbon ions) makes it possible to further improve dose deposition to the tumor, while sparing the surrounding healthy tissues. Despite these improvements, radioresistance and tumor recurrence are still observed. Although the mechanisms underlying resistance to conventional radiotherapy are well-studied, scientific evidence on the impact of charged particle therapy on cancer cell radioresistance is restricted. The purpose of this review is to discuss the potential role that charged particles could play to overcome radioresistance. This review will focus on hypoxia, cancer stem cells, and specific signaling pathways of EGFR, NFkB, and Hedgehog as well as DNA damage signaling involving PARP, as mechanisms of radioresistance for which pharmacological targets have been identified. Finally, new lines of future research will be proposed, with a focus on novel molecular inhibitors that could be used in combination with charged particle therapy as a novel treatment option for radioresistant tumors.

AB - Radiotherapy plays a central role in the treatment of cancer patients. Over the past decades, remarkable technological progress has been made in the field of conventional radiotherapy. In addition, the use of charged particles (e.g., protons and carbon ions) makes it possible to further improve dose deposition to the tumor, while sparing the surrounding healthy tissues. Despite these improvements, radioresistance and tumor recurrence are still observed. Although the mechanisms underlying resistance to conventional radiotherapy are well-studied, scientific evidence on the impact of charged particle therapy on cancer cell radioresistance is restricted. The purpose of this review is to discuss the potential role that charged particles could play to overcome radioresistance. This review will focus on hypoxia, cancer stem cells, and specific signaling pathways of EGFR, NFkB, and Hedgehog as well as DNA damage signaling involving PARP, as mechanisms of radioresistance for which pharmacological targets have been identified. Finally, new lines of future research will be proposed, with a focus on novel molecular inhibitors that could be used in combination with charged particle therapy as a novel treatment option for radioresistant tumors.

KW - Radioresistance

KW - Radiosensitization

KW - X-rays

KW - Proton therapy

KW - Particle therapy

KW - Carbon ion therapy

KW - Molecular targeted drugs

KW - Combination treatment

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/open/37866430

U2 - 10.3389/fonc.2020.00128

DO - 10.3389/fonc.2020.00128

M3 - Article

VL - 10

SP - 1

EP - 21

JO - Frontiers in Oncology

JF - Frontiers in Oncology

SN - 2234-943X

M1 - 128

ER -

ID: 6765996