Comparative chemical protection to the intestinal and hematopoietic systems of whole-body X-irradiated mice

Research output: Report/bookBLG - Open reportpeer-review

Authors

  • Jean Maisin
  • D.G. Doherty
  • ORNL - Oak Ridge National Laboratory

Documents & links

Abstract

Chemical protection by AETy MEA, D-2-ABT, APMT, serotonin. and a combination of AET and serotonin of the alimentary tracts of mice against 900, 1500, 2000, and 2500 r, and the hematopoietic system after 1500 r has been studied. AET and MEA offered the best intestinal protection, AET being superior to MEA at all dose levels,. Doubling the optimal intraperitoneal dose of AET and MEA by oral administration failed to increase the degree of intestinal protection. Combined treatment with AET and serotonin, whiIe providing better protection to the bone marrow than either alone, did not increase Intestinal protection beyond
that of AET alone.

Details

Original languageEnglish
PublisherSCK CEN
Number of pages12
Publication statusPublished - Nov 1963

Publication series

NameSCK CEN Reports
PublisherSCK CEN
No.BLG-249

ID: 7834127