Concerted Uranium Research in Europe (CURE), toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure.

Research output: Contribution to journalArticle

Authors

  • Olivier Laurent
  • Maria Gomolka
  • Richard Haylock
  • Eric Blanchardon
  • Augusto Giussani
  • Will Atkinson
  • Derek Bingham
  • Elisabeth Cardis
  • Janet Hall
  • Ladislav Tomasek
  • Sophie Ancelet
  • Christophe Badie
  • Gary Bethel
  • Jean-Marc Bertho
  • Ségolène Bouet
  • Richard Bull
  • Cécile Challeton-de Vathaire
  • Rupert Cockerill
  • Estelle Davesne
  • Teni Ebrahimian
  • Hilde Engels
  • Michael Gillies
  • James Grellier
  • Stephane Grison
  • Yann Gueguen
  • Sabine Hornhardt
  • Chrystelle Ibanez
  • Sylwia Kabacik
  • Lukas Kotik
  • Michaela Kreuzer
  • James Marsh
  • Dietmar Nosske
  • Jackie O'Hagan
  • Eileen Pernot
  • Matthew Puncher
  • Estelle Rage
  • Tony Riddell
  • Laurence Roy
  • Eric Samson
  • Maamar Souidi
  • Michelle C. Turner
  • Sergey Zhivin
  • Dominique Laurier

Documents & links

Abstract

The potential health impacts of chronic exposures to uranium, as they occur in occupational settings, are not well characterized. Most epidemiological studies have been limited by small sample sizes, and a lack of harmonization of methods used to quantify radiation doses resulting from uranium exposure. Experimental studies have shown that uranium has biological effects, but their implications for human health are not clear. New studies that would combine the strengths of large, well-designed epidemiological datasets with those of state-of-the-art biological methods would help improve the characterization of the biological and health effects of occupational uranium exposure. The aim of the European Commission concerted action CURE (Concerted Uranium Research in Europe) was to develop protocols for such a future collaborative research project, in which dosimetry, epidemiology and biology would be integrated to better characterize the effects of occupational uranium exposure. These protocols were developed from existing European cohorts of workers exposed to uranium together with expertise in epidemiology, biology and dosimetry of CURE partner institutions. The preparatory work of CURE should allow a large scale collaborative project to be launched, in order to better characterize the effects of uranium exposure and more generally of alpha particles and low doses of ionizing radiation.

Details

Original languageEnglish
Pages (from-to)319-345
Number of pages27
JournalJournal of Radiological protection
Volume36
DOIs
Publication statusPublished - 31 May 2016

Keywords

  • uranium, biomarkers, radionuclides, dosimetry, epidemiology, occupational exposure

ID: 1465081