Current evidence for a role of epigenetic mechanisms in response to ionizing radiation in an ecotoxicological context

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Current evidence for a role of epigenetic mechanisms in response to ionizing radiation in an ecotoxicological context. / Horemans, Nele; Spurgeon, David; Lecomte-Pradines, Catherine; Saenen, Eline; Bradshaw, C.; Oughton, Deborah; Rasnaca, Ilza; Kamstra, Jorke; Adam-Guillermin, Christelle.

In: Environmental Pollution, Vol. 251, 08.05.2019, p. 469-483.

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Harvard

Horemans, N, Spurgeon, D, Lecomte-Pradines, C, Saenen, E, Bradshaw, C, Oughton, D, Rasnaca, I, Kamstra, J & Adam-Guillermin, C 2019, 'Current evidence for a role of epigenetic mechanisms in response to ionizing radiation in an ecotoxicological context', Environmental Pollution, vol. 251, pp. 469-483. https://doi.org/10.1016/j.envpol.2019.04.125

APA

Horemans, N., Spurgeon, D., Lecomte-Pradines, C., Saenen, E., Bradshaw, C., Oughton, D., ... Adam-Guillermin, C. (2019). Current evidence for a role of epigenetic mechanisms in response to ionizing radiation in an ecotoxicological context. Environmental Pollution, 251, 469-483. https://doi.org/10.1016/j.envpol.2019.04.125

Vancouver

Author

Horemans, Nele ; Spurgeon, David ; Lecomte-Pradines, Catherine ; Saenen, Eline ; Bradshaw, C. ; Oughton, Deborah ; Rasnaca, Ilza ; Kamstra, Jorke ; Adam-Guillermin, Christelle. / Current evidence for a role of epigenetic mechanisms in response to ionizing radiation in an ecotoxicological context. In: Environmental Pollution. 2019 ; Vol. 251. pp. 469-483.

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@article{e84099d11a8c488bafc80998b8cb8258,
title = "Current evidence for a role of epigenetic mechanisms in response to ionizing radiation in an ecotoxicological context",
abstract = "The issue of potential long-term or hereditary effects for both humans and wildlife exposed to low doses (or dose rates) of ionising radiation is a major concern. Chronic exposure to ionising radiation, defined as an exposure over a large fraction of the organism's lifespan or even over several generations, can possibly have consequences in the progeny. Recent work has begun to show that epigenetics plays an important role in adaptation of organisms challenged to environmental stimulae. Changes to so-called epigenetic marks such as histone modifications, DNA methylation and non-coding RNAs result in altered transcriptomes and proteomes, without directly changing the DNA sequence. Moreover, some of these environmentally-induced epigenetic changes tend to persist over generations, and thus, epigenetic modifications are regarded as the conduits for environmental influence on the genome. Here, we review the current knowledge of possible involvement of epigenetics in the cascade of responses resulting from environmental exposure to ionising radiation. In addition, from a comparison of lab and field obtained data, we investigate evidence on radiation-induced changes in the epigenome and in particular the total or locus specific levels of DNA methylation. The challenges for future research and possible use of changes as an early warning (biomarker) of radiosensitivity and individual exposure is discussed. Such a biomarker could be used to detect and better understand the mechanisms of toxic action and inter/intra-species susceptibility to radiation within an environmental risk assessment and management context.",
keywords = "Epigenetic marks, DNA methylation, Gamma radiation, Chronic exposure, Multi-transgenerational, Wildlife Chernobyl, Chernobyl, Fukushima, Nuclear accidents",
author = "Nele Horemans and David Spurgeon and Catherine Lecomte-Pradines and Eline Saenen and C. Bradshaw and Deborah Oughton and Ilza Rasnaca and Jorke Kamstra and Christelle Adam-Guillermin",
note = "Score=10",
year = "2019",
month = "5",
day = "8",
doi = "10.1016/j.envpol.2019.04.125",
language = "English",
volume = "251",
pages = "469--483",
journal = "Environmental Pollution",
issn = "0269-7491",
publisher = "Elsevier",

}

RIS - Download

TY - JOUR

T1 - Current evidence for a role of epigenetic mechanisms in response to ionizing radiation in an ecotoxicological context

AU - Horemans, Nele

AU - Spurgeon, David

AU - Lecomte-Pradines, Catherine

AU - Saenen, Eline

AU - Bradshaw, C.

AU - Oughton, Deborah

AU - Rasnaca, Ilza

AU - Kamstra, Jorke

AU - Adam-Guillermin, Christelle

N1 - Score=10

PY - 2019/5/8

Y1 - 2019/5/8

N2 - The issue of potential long-term or hereditary effects for both humans and wildlife exposed to low doses (or dose rates) of ionising radiation is a major concern. Chronic exposure to ionising radiation, defined as an exposure over a large fraction of the organism's lifespan or even over several generations, can possibly have consequences in the progeny. Recent work has begun to show that epigenetics plays an important role in adaptation of organisms challenged to environmental stimulae. Changes to so-called epigenetic marks such as histone modifications, DNA methylation and non-coding RNAs result in altered transcriptomes and proteomes, without directly changing the DNA sequence. Moreover, some of these environmentally-induced epigenetic changes tend to persist over generations, and thus, epigenetic modifications are regarded as the conduits for environmental influence on the genome. Here, we review the current knowledge of possible involvement of epigenetics in the cascade of responses resulting from environmental exposure to ionising radiation. In addition, from a comparison of lab and field obtained data, we investigate evidence on radiation-induced changes in the epigenome and in particular the total or locus specific levels of DNA methylation. The challenges for future research and possible use of changes as an early warning (biomarker) of radiosensitivity and individual exposure is discussed. Such a biomarker could be used to detect and better understand the mechanisms of toxic action and inter/intra-species susceptibility to radiation within an environmental risk assessment and management context.

AB - The issue of potential long-term or hereditary effects for both humans and wildlife exposed to low doses (or dose rates) of ionising radiation is a major concern. Chronic exposure to ionising radiation, defined as an exposure over a large fraction of the organism's lifespan or even over several generations, can possibly have consequences in the progeny. Recent work has begun to show that epigenetics plays an important role in adaptation of organisms challenged to environmental stimulae. Changes to so-called epigenetic marks such as histone modifications, DNA methylation and non-coding RNAs result in altered transcriptomes and proteomes, without directly changing the DNA sequence. Moreover, some of these environmentally-induced epigenetic changes tend to persist over generations, and thus, epigenetic modifications are regarded as the conduits for environmental influence on the genome. Here, we review the current knowledge of possible involvement of epigenetics in the cascade of responses resulting from environmental exposure to ionising radiation. In addition, from a comparison of lab and field obtained data, we investigate evidence on radiation-induced changes in the epigenome and in particular the total or locus specific levels of DNA methylation. The challenges for future research and possible use of changes as an early warning (biomarker) of radiosensitivity and individual exposure is discussed. Such a biomarker could be used to detect and better understand the mechanisms of toxic action and inter/intra-species susceptibility to radiation within an environmental risk assessment and management context.

KW - Epigenetic marks

KW - DNA methylation

KW - Gamma radiation

KW - Chronic exposure

KW - Multi-transgenerational

KW - Wildlife Chernobyl

KW - Chernobyl

KW - Fukushima

KW - Nuclear accidents

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/34631524

U2 - 10.1016/j.envpol.2019.04.125

DO - 10.1016/j.envpol.2019.04.125

M3 - Article

VL - 251

SP - 469

EP - 483

JO - Environmental Pollution

JF - Environmental Pollution

SN - 0269-7491

ER -

ID: 5322313