Current Evidence for Developmental, Structural, and Functional Brain Defects following Prenatal Radiation Exposure

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@article{cc6b9cb21a9c4ca5a188089eea283c22,
title = "Current Evidence for Developmental, Structural, and Functional Brain Defects following Prenatal Radiation Exposure",
abstract = "Ionizing radiation is omnipresent. We are continuously exposed to natural (e.g., radon and cosmic) and man-made radiation sources, including those from industry but especially from the medical sector.The increasing use of medical radiation modalities, in particular those employing low-dose radiation such as CT scans, raises concerns regarding the effects of cumulative exposure doses and the inappropriate utilization of these imaging techniques. One of the major goals in the radioprotection field is to better understand the potential health risk posed to the unborn child after radiation exposure to the pregnant mother, of which the first convincing evidence came fromepidemiological studies on in utero exposed atomic bomb survivors. In the following years, animal models have proven to be an essential tool to further characterize brain developmental defects and consequent functional deficits. However, the identification of a possible dose threshold is far from complete and a sound link between early defects and persistent anomalies has not yet been established. This review provides an overview of the current knowledge on brain developmental and persistent defects resulting from in utero radiation exposure and addresses the many questions that still remain to be answered.",
keywords = "brain development, embryology, irradiation",
author = "Tine Verreet and Mieke Verslegers and Roel Quintens and Sarah Baatout and Rafi Benotmane",
note = "Score=10",
year = "2016",
month = "5",
day = "12",
doi = "10.1155/2016/1243527",
language = "English",
volume = "2016",
journal = "Neural Plasticity",
issn = "2090-5904",
publisher = "Hindawi - Hindawi Publishing Corporation",

}

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TY - JOUR

T1 - Current Evidence for Developmental, Structural, and Functional Brain Defects following Prenatal Radiation Exposure

AU - Verreet, Tine

AU - Verslegers, Mieke

AU - Quintens, Roel

AU - Baatout, Sarah

AU - Benotmane, Rafi

N1 - Score=10

PY - 2016/5/12

Y1 - 2016/5/12

N2 - Ionizing radiation is omnipresent. We are continuously exposed to natural (e.g., radon and cosmic) and man-made radiation sources, including those from industry but especially from the medical sector.The increasing use of medical radiation modalities, in particular those employing low-dose radiation such as CT scans, raises concerns regarding the effects of cumulative exposure doses and the inappropriate utilization of these imaging techniques. One of the major goals in the radioprotection field is to better understand the potential health risk posed to the unborn child after radiation exposure to the pregnant mother, of which the first convincing evidence came fromepidemiological studies on in utero exposed atomic bomb survivors. In the following years, animal models have proven to be an essential tool to further characterize brain developmental defects and consequent functional deficits. However, the identification of a possible dose threshold is far from complete and a sound link between early defects and persistent anomalies has not yet been established. This review provides an overview of the current knowledge on brain developmental and persistent defects resulting from in utero radiation exposure and addresses the many questions that still remain to be answered.

AB - Ionizing radiation is omnipresent. We are continuously exposed to natural (e.g., radon and cosmic) and man-made radiation sources, including those from industry but especially from the medical sector.The increasing use of medical radiation modalities, in particular those employing low-dose radiation such as CT scans, raises concerns regarding the effects of cumulative exposure doses and the inappropriate utilization of these imaging techniques. One of the major goals in the radioprotection field is to better understand the potential health risk posed to the unborn child after radiation exposure to the pregnant mother, of which the first convincing evidence came fromepidemiological studies on in utero exposed atomic bomb survivors. In the following years, animal models have proven to be an essential tool to further characterize brain developmental defects and consequent functional deficits. However, the identification of a possible dose threshold is far from complete and a sound link between early defects and persistent anomalies has not yet been established. This review provides an overview of the current knowledge on brain developmental and persistent defects resulting from in utero radiation exposure and addresses the many questions that still remain to be answered.

KW - brain development

KW - embryology

KW - irradiation

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/20017937

UR - https://www.hindawi.com/journals/np/2016/1243527/

U2 - 10.1155/2016/1243527

DO - 10.1155/2016/1243527

M3 - Article

VL - 2016

JO - Neural Plasticity

JF - Neural Plasticity

SN - 2090-5904

M1 - 1243527

ER -

ID: 1527404