Dose estimation for the European epidemiological study on pediatric computed tomography (EPI-CT)

Research output: Contribution to journalArticlepeer-review

Authors

  • Isabelle Thierry-Chef
  • Gilles Ferro
  • Lucian Le Cornet
  • Tore Istad
  • Andreas Jahnen
  • Choonsik Lee
  • Carlos Maccia
  • Françoise L. Malchair
  • Hilde Olerud
  • Richard W. Harbron
  • Jordi Figuerola
  • Johannes Hermen
  • Monika Moissonnier
  • Marie-Odile Bernier
  • Maria Bosch de Basea
  • Graham Byrnes
  • Elisabeth Cardis
  • Michael Hauptmann
  • Neige Journy
  • Ausrele Kesminiene
  • Johanna M. Meulepas
  • Roman Pokora
  • Steven Simon

Institutes & Expert groups

  • IARC - International Agency for Research on Cancer
  • ISGlobal - Barcelona Institute of Global Health
  • DCEG - National Cancer Institute - Devision of Cancer Epidemiology & Genetics
  • NPRA - Norwegian Radiation Protection Authority
  • CRP - Centre de recherche public Henri-Tudor
  • NCI - National Cancer Institute
  • Centre d’Assurance de qualité des Applications Technologiques dans le domaine de la Santé
  • ULG - Université de Liège
  • UNS - University of South-Eastern Norway
  • Newcastle University - Institute of Health and Society
  • LIST - Luxembourg Institute of Science and Technology
  • IRSN - Institute for Radioprotection and Nuclear Safety - Institut Radioprotection Sûreté Nucléaire
  • CREAL - Centre for Research in Environmental Epidemiology
  • NKI - Netherlands Cancer Institute
  • IMBEI - Johannes Gutenberg-Universität Mainz - Institut für Medizinische Biometrie, Epidemiologie und Informatik

Documents & links

DOI

Abstract

Within the European Epidemiological Study to Quantify Risks for Paediatric Computerized Tomography (EPI-CT study), a cohort was assembled comprising nearly one million children, adolescents and young adults who received over 1.4 million computed tomography (CT) examinations before 22 years of age in nine European countries from the late 1970s to 2014. Here we describe the methods used for, and the results of, organ dose estimations from CT scanning for the EPI-CT cohort members. Data on CT machine settings were obtained from national surveys, questionnaire data, and the Digital Imaging and Communications in Medicine (DICOM) headers of 437,249 individual CT scans. Exposure characteristics were reconstructed for patients within specific age groups who received scans of the same body region, based on categories of machines with common technology used over the time period in each of the 276 participating hospitals. A carefully designed method for assessing uncertainty combined with the National Cancer Institute Dosimetry System for CT (NCICT, a CT organ dose calculator), was employed to estimate absorbed dose to individual organs for each CT scan received. The two-dimensional Monte Carlo sampling method, which maintains a separation of shared and unshared error, allowed us to characterize uncertainty both on individual doses as well as for the entire cohort dose distribution. Provided here are summaries of estimated doses from CT imaging per scan and per examination, as well as the overall distribution of estimated doses in the cohort. Doses are provided for five selected tissues (active bone marrow, brain, eye lens, thyroid and female breasts), by body region (i.e., head, chest, abdomen/pelvis), patient age, and time period (1977–1990, 1991–2000, 2001–2014). Relatively high doses were received by the brain from head CTs in the early 1990s, with individual mean doses (mean of 200 simulated values) of up to 66 mGy per scan. Optimization strategies implemented since the late 1990s have resulted in an overall decrease in doses over time, especially at young ages. In chest CTs, active bone marrow doses dropped from over 15 mGy prior to 1991 to approximately 5 mGy per scan after 2001. Our findings illustrate patterns of age-specific doses and their temporal changes, and provide suitable dose estimates for radiation-induced risk estimation in epidemiological studies.

Details

Original languageEnglish
Pages (from-to)74-99
Number of pages26
JournalRadiation Research
Volume196
DOIs
Publication statusPublished - 28 Apr 2021

Keywords

  • Computed tomography, Paediatric CT, Dosimetry, Organ doses, Dose reconstructions

ID: 7393600