EPI-CT Design, challenges and epidemiological methods of an international study on cancer risk after paediatric CT

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EPI-CT Design, challenges and epidemiological methods of an international study on cancer risk after paediatric CT. / Basea, Magda Bosch de; Pearce, Mark S.; Kesminiene, Ausrele; Bernier, Marie-Odile; Dabin, Jérémie; Engels, Hilde; Hauptmann, Michael; Krille, Lucian; Meulepas, Johanna M.; Struelens, Lara; Baatout, Sarah; Kaijser, Magnus; Maccia, Carlo; Jahnen, Andreas; Thierry-Chef, Isabelle; Blettner, Maria; Johansen, Christoffer; Kjaerheim, Kristina; Nordenskjöld, Arvid; Olerud, Hilde; Salotti, Jane A.; Andersen, Tina Veje; Vrijheid, Martine; Cardis, Elisabeth.

In: Journal of Radiological protection, Vol. 35, No. 3, 30.07.2015, p. 611-628.

Research output: Contribution to journalArticlepeer-review

Harvard

Basea, MBD, Pearce, MS, Kesminiene, A, Bernier, M-O, Dabin, J, Engels, H, Hauptmann, M, Krille, L, Meulepas, JM, Struelens, L, Baatout, S, Kaijser, M, Maccia, C, Jahnen, A, Thierry-Chef, I, Blettner, M, Johansen, C, Kjaerheim, K, Nordenskjöld, A, Olerud, H, Salotti, JA, Andersen, TV, Vrijheid, M & Cardis, E 2015, 'EPI-CT Design, challenges and epidemiological methods of an international study on cancer risk after paediatric CT', Journal of Radiological protection, vol. 35, no. 3, pp. 611-628. https://doi.org/10.1088/0952-4746/35/3/611

APA

Basea, M. B. D., Pearce, M. S., Kesminiene, A., Bernier, M-O., Dabin, J., Engels, H., Hauptmann, M., Krille, L., Meulepas, J. M., Struelens, L., Baatout, S., Kaijser, M., Maccia, C., Jahnen, A., Thierry-Chef, I., Blettner, M., Johansen, C., Kjaerheim, K., Nordenskjöld, A., ... Cardis, E. (2015). EPI-CT Design, challenges and epidemiological methods of an international study on cancer risk after paediatric CT. Journal of Radiological protection, 35(3), 611-628. https://doi.org/10.1088/0952-4746/35/3/611

Vancouver

Basea MBD, Pearce MS, Kesminiene A, Bernier M-O, Dabin J, Engels H et al. EPI-CT Design, challenges and epidemiological methods of an international study on cancer risk after paediatric CT. Journal of Radiological protection. 2015 Jul 30;35(3):611-628. https://doi.org/10.1088/0952-4746/35/3/611

Author

Basea, Magda Bosch de ; Pearce, Mark S. ; Kesminiene, Ausrele ; Bernier, Marie-Odile ; Dabin, Jérémie ; Engels, Hilde ; Hauptmann, Michael ; Krille, Lucian ; Meulepas, Johanna M. ; Struelens, Lara ; Baatout, Sarah ; Kaijser, Magnus ; Maccia, Carlo ; Jahnen, Andreas ; Thierry-Chef, Isabelle ; Blettner, Maria ; Johansen, Christoffer ; Kjaerheim, Kristina ; Nordenskjöld, Arvid ; Olerud, Hilde ; Salotti, Jane A. ; Andersen, Tina Veje ; Vrijheid, Martine ; Cardis, Elisabeth. / EPI-CT Design, challenges and epidemiological methods of an international study on cancer risk after paediatric CT. In: Journal of Radiological protection. 2015 ; Vol. 35, No. 3. pp. 611-628.

Bibtex - Download

@article{f075e0d5307d4c1a8d9c4c88780de867,
title = "EPI-CT Design, challenges and epidemiological methods of an international study on cancer risk after paediatric CT",
abstract = "Introduction: Computed tomography (CT) has great clinical utility and its usage has increased dramatically over the last decades. Concerns have been raised, however, about health impacts of ionising radiation exposure from CTs, particularly in children, who have a higher risk for some radiation induced diseases and a longer life expectancy than adults. Direct estimation of the health impact of these exposures is needed, but the conduct of epidemiological studies of paediatric CT populations poses a number of challenges which, if not addressed, could invalidate the results. Objective: To review the main challenges of a study on the health impact of paediatric CTs and how the protocol of the European collaborative study EPI-CT, coordinated by the International Agency for Research on Cancer (IARC), is designed to address them. Methods: The study, based on a common protocol, is being conducted in Belgium, Denmark, France, Germany, the Netherlands, Norway, Spain, Sweden and the United Kingdom. Cohort accrual relies on records of participating hospital radiology departments. Basic demographic information and technical data on the CT procedure needed to estimate organ doses are being abstracted and passive follow-up is being conducted by linkage to population-based cancer and mortality registries. The main issues which may affect the validity of study results include missing doses from other radiological procedures, missing CTs, confounding by CT indication and socioeconomic status and dose reconstruction. Sub-studies are underway to evaluate their potential impact. Discussion: By focusing on the issues which challenge the validity of risk estimates from CT exposures, EPI-CT, which has recruited over one million patients suitable for long-term prospective follow-up, will be able to address limitations of previous CT studies, thus providing reliable estimates of risk of solid tumours and leukaemia from paediatric CT exposures and scientific bases for the optimisation of paediatric CT protocols and patient protection.",
keywords = "epidemiological studies, radiobiology, dosimetry",
author = "Basea, {Magda Bosch de} and Pearce, {Mark S.} and Ausrele Kesminiene and Marie-Odile Bernier and J{\'e}r{\'e}mie Dabin and Hilde Engels and Michael Hauptmann and Lucian Krille and Meulepas, {Johanna M.} and Lara Struelens and Sarah Baatout and Magnus Kaijser and Carlo Maccia and Andreas Jahnen and Isabelle Thierry-Chef and Maria Blettner and Christoffer Johansen and Kristina Kjaerheim and Arvid Nordenskj{\"o}ld and Hilde Olerud and Salotti, {Jane A.} and Andersen, {Tina Veje} and Martine Vrijheid and Elisabeth Cardis",
note = "Score=10",
year = "2015",
month = jul,
day = "30",
doi = "10.1088/0952-4746/35/3/611",
language = "English",
volume = "35",
pages = "611--628",
journal = "Journal of Radiological protection",
issn = "0952-4746",
publisher = "IOP - IOP Publishing",
number = "3",

}

RIS - Download

TY - JOUR

T1 - EPI-CT Design, challenges and epidemiological methods of an international study on cancer risk after paediatric CT

AU - Basea, Magda Bosch de

AU - Pearce, Mark S.

AU - Kesminiene, Ausrele

AU - Bernier, Marie-Odile

AU - Dabin, Jérémie

AU - Engels, Hilde

AU - Hauptmann, Michael

AU - Krille, Lucian

AU - Meulepas, Johanna M.

AU - Struelens, Lara

AU - Baatout, Sarah

AU - Kaijser, Magnus

AU - Maccia, Carlo

AU - Jahnen, Andreas

AU - Thierry-Chef, Isabelle

AU - Blettner, Maria

AU - Johansen, Christoffer

AU - Kjaerheim, Kristina

AU - Nordenskjöld, Arvid

AU - Olerud, Hilde

AU - Salotti, Jane A.

AU - Andersen, Tina Veje

AU - Vrijheid, Martine

AU - Cardis, Elisabeth

N1 - Score=10

PY - 2015/7/30

Y1 - 2015/7/30

N2 - Introduction: Computed tomography (CT) has great clinical utility and its usage has increased dramatically over the last decades. Concerns have been raised, however, about health impacts of ionising radiation exposure from CTs, particularly in children, who have a higher risk for some radiation induced diseases and a longer life expectancy than adults. Direct estimation of the health impact of these exposures is needed, but the conduct of epidemiological studies of paediatric CT populations poses a number of challenges which, if not addressed, could invalidate the results. Objective: To review the main challenges of a study on the health impact of paediatric CTs and how the protocol of the European collaborative study EPI-CT, coordinated by the International Agency for Research on Cancer (IARC), is designed to address them. Methods: The study, based on a common protocol, is being conducted in Belgium, Denmark, France, Germany, the Netherlands, Norway, Spain, Sweden and the United Kingdom. Cohort accrual relies on records of participating hospital radiology departments. Basic demographic information and technical data on the CT procedure needed to estimate organ doses are being abstracted and passive follow-up is being conducted by linkage to population-based cancer and mortality registries. The main issues which may affect the validity of study results include missing doses from other radiological procedures, missing CTs, confounding by CT indication and socioeconomic status and dose reconstruction. Sub-studies are underway to evaluate their potential impact. Discussion: By focusing on the issues which challenge the validity of risk estimates from CT exposures, EPI-CT, which has recruited over one million patients suitable for long-term prospective follow-up, will be able to address limitations of previous CT studies, thus providing reliable estimates of risk of solid tumours and leukaemia from paediatric CT exposures and scientific bases for the optimisation of paediatric CT protocols and patient protection.

AB - Introduction: Computed tomography (CT) has great clinical utility and its usage has increased dramatically over the last decades. Concerns have been raised, however, about health impacts of ionising radiation exposure from CTs, particularly in children, who have a higher risk for some radiation induced diseases and a longer life expectancy than adults. Direct estimation of the health impact of these exposures is needed, but the conduct of epidemiological studies of paediatric CT populations poses a number of challenges which, if not addressed, could invalidate the results. Objective: To review the main challenges of a study on the health impact of paediatric CTs and how the protocol of the European collaborative study EPI-CT, coordinated by the International Agency for Research on Cancer (IARC), is designed to address them. Methods: The study, based on a common protocol, is being conducted in Belgium, Denmark, France, Germany, the Netherlands, Norway, Spain, Sweden and the United Kingdom. Cohort accrual relies on records of participating hospital radiology departments. Basic demographic information and technical data on the CT procedure needed to estimate organ doses are being abstracted and passive follow-up is being conducted by linkage to population-based cancer and mortality registries. The main issues which may affect the validity of study results include missing doses from other radiological procedures, missing CTs, confounding by CT indication and socioeconomic status and dose reconstruction. Sub-studies are underway to evaluate their potential impact. Discussion: By focusing on the issues which challenge the validity of risk estimates from CT exposures, EPI-CT, which has recruited over one million patients suitable for long-term prospective follow-up, will be able to address limitations of previous CT studies, thus providing reliable estimates of risk of solid tumours and leukaemia from paediatric CT exposures and scientific bases for the optimisation of paediatric CT protocols and patient protection.

KW - epidemiological studies

KW - radiobiology

KW - dosimetry

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/19600905

U2 - 10.1088/0952-4746/35/3/611

DO - 10.1088/0952-4746/35/3/611

M3 - Article

VL - 35

SP - 611

EP - 628

JO - Journal of Radiological protection

JF - Journal of Radiological protection

SN - 0952-4746

IS - 3

ER -

ID: 262649