Epigenetic, metabolic, and signal transduction pathways involved in radiation response of normal and transformed thyrocytes

Research output: ThesisDoctoral thesis

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@phdthesis{92ada97cc5a84b478f100f4784a12fcc,
title = "Epigenetic, metabolic, and signal transduction pathways involved in radiation response of normal and transformed thyrocytes",
abstract = "In this PhD, we were interested to investigate the effect of a range of external X-ray doses covering the low to high on Papillary Thyroid Carcinoma (PTC) cells with a RET/PTC translocation, on thyroid cells with a RET/PTC translocation but no discernable PTC morphology, and on normal thyroids. We chose a range of doses from 62.5 mGy to 4 Gy as it falls within the range of doses to the thyroid received by residents of the areas surrounding the Chernobyl NPP site (90 mGy to 12 Gy). By using an array of high-throughput techniques, we have identified the difference in the response of these three thyroid systems.",
keywords = "thyroid, epigenetics, metabolic, signal transduction, radiation, cancer",
author = "Khalil Abouelaradat and Paul Jacquet",
note = "Score = 6",
year = "2011",
month = "11",
day = "21",
language = "English",
isbn = "9789059894846",
publisher = "UGent - Universiteit Gent",
address = "Belgium",
school = "UGent - Universiteit Gent",

}

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TY - THES

T1 - Epigenetic, metabolic, and signal transduction pathways involved in radiation response of normal and transformed thyrocytes

AU - Abouelaradat, Khalil

A2 - Jacquet, Paul

N1 - Score = 6

PY - 2011/11/21

Y1 - 2011/11/21

N2 - In this PhD, we were interested to investigate the effect of a range of external X-ray doses covering the low to high on Papillary Thyroid Carcinoma (PTC) cells with a RET/PTC translocation, on thyroid cells with a RET/PTC translocation but no discernable PTC morphology, and on normal thyroids. We chose a range of doses from 62.5 mGy to 4 Gy as it falls within the range of doses to the thyroid received by residents of the areas surrounding the Chernobyl NPP site (90 mGy to 12 Gy). By using an array of high-throughput techniques, we have identified the difference in the response of these three thyroid systems.

AB - In this PhD, we were interested to investigate the effect of a range of external X-ray doses covering the low to high on Papillary Thyroid Carcinoma (PTC) cells with a RET/PTC translocation, on thyroid cells with a RET/PTC translocation but no discernable PTC morphology, and on normal thyroids. We chose a range of doses from 62.5 mGy to 4 Gy as it falls within the range of doses to the thyroid received by residents of the areas surrounding the Chernobyl NPP site (90 mGy to 12 Gy). By using an array of high-throughput techniques, we have identified the difference in the response of these three thyroid systems.

KW - thyroid

KW - epigenetics

KW - metabolic

KW - signal transduction

KW - radiation

KW - cancer

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_117455_2

M3 - Doctoral thesis

SN - 9789059894846

PB - UGent - Universiteit Gent

CY - Gent, Belgium

ER -

ID: 168149