ESA IBER-2: Molecular and Cellular Changes in Human Endothelial Cells in Response to Nickel Ion Irradiation (CORALS project)

Research output: Contribution to report/book/conference proceedingsIn-proceedings paper

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ESA IBER-2: Molecular and Cellular Changes in Human Endothelial Cells in Response to Nickel Ion Irradiation (CORALS project). / Moreels, Marjan; Quintens, Roel; De Vos, Winnok; Beck, Michaël; Tabury, Kevin; Suetens, Annelies; Abouelaradat, Khalil; Dieriks, Birger; Ernst, Eric; Lee, Ryonfa; Lambert, Charles; Van Oostveldt, Patrick; Baatout, Sarah.

SP-706 Life in Space for Life on Earth. Noordwijk, Netherlands, 2013. (Spacebooks Online; No. SP-706).

Research output: Contribution to report/book/conference proceedingsIn-proceedings paper

Harvard

Moreels, M, Quintens, R, De Vos, W, Beck, M, Tabury, K, Suetens, A, Abouelaradat, K, Dieriks, B, Ernst, E, Lee, R, Lambert, C, Van Oostveldt, P & Baatout, S 2013, ESA IBER-2: Molecular and Cellular Changes in Human Endothelial Cells in Response to Nickel Ion Irradiation (CORALS project). in SP-706 Life in Space for Life on Earth. Spacebooks Online, no. SP-706, Noordwijk, Netherlands, Life in Space for Life on Earth, Aberdeen, United Kingdom, 2012-06-17.

APA

Moreels, M., Quintens, R., De Vos, W., Beck, M., Tabury, K., Suetens, A., ... Baatout, S. (2013). ESA IBER-2: Molecular and Cellular Changes in Human Endothelial Cells in Response to Nickel Ion Irradiation (CORALS project). In SP-706 Life in Space for Life on Earth (Spacebooks Online; No. SP-706). Noordwijk, Netherlands.

Vancouver

Moreels M, Quintens R, De Vos W, Beck M, Tabury K, Suetens A et al. ESA IBER-2: Molecular and Cellular Changes in Human Endothelial Cells in Response to Nickel Ion Irradiation (CORALS project). In SP-706 Life in Space for Life on Earth. Noordwijk, Netherlands. 2013. (Spacebooks Online; SP-706).

Author

Moreels, Marjan ; Quintens, Roel ; De Vos, Winnok ; Beck, Michaël ; Tabury, Kevin ; Suetens, Annelies ; Abouelaradat, Khalil ; Dieriks, Birger ; Ernst, Eric ; Lee, Ryonfa ; Lambert, Charles ; Van Oostveldt, Patrick ; Baatout, Sarah. / ESA IBER-2: Molecular and Cellular Changes in Human Endothelial Cells in Response to Nickel Ion Irradiation (CORALS project). SP-706 Life in Space for Life on Earth. Noordwijk, Netherlands, 2013. (Spacebooks Online; SP-706).

Bibtex - Download

@inproceedings{344f7d9b2d884d1895d399594f21ff14,
title = "ESA IBER-2: Molecular and Cellular Changes in Human Endothelial Cells in Response to Nickel Ion Irradiation (CORALS project)",
abstract = "On Earth, most radiation exposures (medical and natural background) consist of low-linear energy transfer (LET) photons. In space, astronauts are exposed to higher doses and to more varied types of radiation. Cosmic radiation mainly consists of high-energy protons and high-Z and -energy (HZE) particles. These high-LET particles are predicted to account for most of the radiation induced health effects. In this regard, further analysis of the biological effects of HZE particles is essential. In the present study, endothelial cells were irradiated with different doses of nickel ions produced in the synchrotron at GSI (Darmstadt, Germany). After different time points, RNA was extracted for genome-wide analysis and supernatants were collected for multiplex cytokine assay. DNA double strand breaks were detected using γH2AX staining. Our results demonstrated that nickel irradiation induced molecular and cellular changes in human endothelial cells. Further analysis is ongoing to confirm the obtained data and to further explore the biological effects after nickel ion exposure.",
keywords = "Space radiation, HZE particles, gene expression, DNA damage",
author = "Marjan Moreels and Roel Quintens and {De Vos}, Winnok and Micha{\"e}l Beck and Kevin Tabury and Annelies Suetens and Khalil Abouelaradat and Birger Dieriks and Eric Ernst and Ryonfa Lee and Charles Lambert and {Van Oostveldt}, Patrick and Sarah Baatout",
note = "Score = 3",
year = "2013",
month = "2",
language = "English",
isbn = "978-92-9221-270-4",
series = "Spacebooks Online",
number = "SP-706",
booktitle = "SP-706 Life in Space for Life on Earth",

}

RIS - Download

TY - GEN

T1 - ESA IBER-2: Molecular and Cellular Changes in Human Endothelial Cells in Response to Nickel Ion Irradiation (CORALS project)

AU - Moreels, Marjan

AU - Quintens, Roel

AU - De Vos, Winnok

AU - Beck, Michaël

AU - Tabury, Kevin

AU - Suetens, Annelies

AU - Abouelaradat, Khalil

AU - Dieriks, Birger

AU - Ernst, Eric

AU - Lee, Ryonfa

AU - Lambert, Charles

AU - Van Oostveldt, Patrick

AU - Baatout, Sarah

N1 - Score = 3

PY - 2013/2

Y1 - 2013/2

N2 - On Earth, most radiation exposures (medical and natural background) consist of low-linear energy transfer (LET) photons. In space, astronauts are exposed to higher doses and to more varied types of radiation. Cosmic radiation mainly consists of high-energy protons and high-Z and -energy (HZE) particles. These high-LET particles are predicted to account for most of the radiation induced health effects. In this regard, further analysis of the biological effects of HZE particles is essential. In the present study, endothelial cells were irradiated with different doses of nickel ions produced in the synchrotron at GSI (Darmstadt, Germany). After different time points, RNA was extracted for genome-wide analysis and supernatants were collected for multiplex cytokine assay. DNA double strand breaks were detected using γH2AX staining. Our results demonstrated that nickel irradiation induced molecular and cellular changes in human endothelial cells. Further analysis is ongoing to confirm the obtained data and to further explore the biological effects after nickel ion exposure.

AB - On Earth, most radiation exposures (medical and natural background) consist of low-linear energy transfer (LET) photons. In space, astronauts are exposed to higher doses and to more varied types of radiation. Cosmic radiation mainly consists of high-energy protons and high-Z and -energy (HZE) particles. These high-LET particles are predicted to account for most of the radiation induced health effects. In this regard, further analysis of the biological effects of HZE particles is essential. In the present study, endothelial cells were irradiated with different doses of nickel ions produced in the synchrotron at GSI (Darmstadt, Germany). After different time points, RNA was extracted for genome-wide analysis and supernatants were collected for multiplex cytokine assay. DNA double strand breaks were detected using γH2AX staining. Our results demonstrated that nickel irradiation induced molecular and cellular changes in human endothelial cells. Further analysis is ongoing to confirm the obtained data and to further explore the biological effects after nickel ion exposure.

KW - Space radiation

KW - HZE particles

KW - gene expression

KW - DNA damage

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_128597

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_128597_2

UR - http://knowledgecentre.sckcen.be/so2/bibref/10180

M3 - In-proceedings paper

SN - 978-92-9221-270-4

T3 - Spacebooks Online

BT - SP-706 Life in Space for Life on Earth

CY - Noordwijk, Netherlands

ER -

ID: 308298