Establishing mechanisms affecting the individual response to ionizing radiation

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Establishing mechanisms affecting the individual response to ionizing radiation. / Averbeck, Dietrich; Candéias, Serge; Chandna, Sudhir; Friedl, Anna A.; Haghdoost, Siamak; Jeggo, Penelope A.; Lumniczky, Katalin; Paris, Francois; Quintens, Roel; Sabatier, Laure.

In: International Journal of Radiation Biology, Vol. 96, No. 3, 08.01.2020, p. 297-323.

Research output: Contribution to journalArticle

Harvard

Averbeck, D, Candéias, S, Chandna, S, Friedl, AA, Haghdoost, S, Jeggo, PA, Lumniczky, K, Paris, F, Quintens, R & Sabatier, L 2020, 'Establishing mechanisms affecting the individual response to ionizing radiation', International Journal of Radiation Biology, vol. 96, no. 3, pp. 297-323. https://doi.org/10.1080/09553002.2019.1704908

APA

Averbeck, D., Candéias, S., Chandna, S., Friedl, A. A., Haghdoost, S., Jeggo, P. A., ... Sabatier, L. (2020). Establishing mechanisms affecting the individual response to ionizing radiation. International Journal of Radiation Biology, 96(3), 297-323. https://doi.org/10.1080/09553002.2019.1704908

Vancouver

Averbeck D, Candéias S, Chandna S, Friedl AA, Haghdoost S, Jeggo PA et al. Establishing mechanisms affecting the individual response to ionizing radiation. International Journal of Radiation Biology. 2020 Jan 8;96(3):297-323. https://doi.org/10.1080/09553002.2019.1704908

Author

Averbeck, Dietrich ; Candéias, Serge ; Chandna, Sudhir ; Friedl, Anna A. ; Haghdoost, Siamak ; Jeggo, Penelope A. ; Lumniczky, Katalin ; Paris, Francois ; Quintens, Roel ; Sabatier, Laure. / Establishing mechanisms affecting the individual response to ionizing radiation. In: International Journal of Radiation Biology. 2020 ; Vol. 96, No. 3. pp. 297-323.

Bibtex - Download

@article{0951dd343e244532b61d002047020ca7,
title = "Establishing mechanisms affecting the individual response to ionizing radiation",
abstract = "Purpose: Humans are increasingly exposed to ionizing radiation (IR). Both low (<100 mGy) and high doses can cause stochastic effects, including cancer; whereas doses above 100 mGy are needed to promote tissue or cell damage. 10–15{\%} of radiotherapy (RT) patients suffer adverse reactions, described as displaying radiosensitivity (RS). Sensitivity to IR’s stochastic effects is termed radiosusceptibility (RSu). To optimize radiation protection we need to understand the range of individual variability and underlying mechanisms. We review the potential mechanisms contribu-ting to RS/RSu focusing on RS following RT, the most tractable RS group. Conclusions: The IR-induced DNA damage response (DDR) has been well characterized. Patients with mutations in the DDR have been identified and display marked RS but they represent only a small percentage of the RT patients with adverse reactions. We review the impacting mechanisms and additional factors influencing RS/RSu. We discuss whether RS/RSu might be genetically deter-mined. As a recommendation, we propose that a prospective study be established to assess RS following RT. The study should detail tumor site and encompass a well-defined grading system. Predictive assays should be independently validated. Detailed analysis of the inflammatory, stress and immune responses, mitochondrial function and life style factors should be included. Existing cohorts should also be optimally exploited.",
keywords = "Radiosensitivity, Radiotherapy, Radiation policy, Radiation-induced cancer, Radiosusceptibility",
author = "Dietrich Averbeck and Serge Cand{\'e}ias and Sudhir Chandna and Friedl, {Anna A.} and Siamak Haghdoost and Jeggo, {Penelope A.} and Katalin Lumniczky and Francois Paris and Roel Quintens and Laure Sabatier",
note = "Score=10",
year = "2020",
month = "1",
day = "8",
doi = "10.1080/09553002.2019.1704908",
language = "English",
volume = "96",
pages = "297--323",
journal = "International Journal of Radiation Biology",
issn = "0955-3002",
publisher = "Taylor & Francis (CRC)",
number = "3",

}

RIS - Download

TY - JOUR

T1 - Establishing mechanisms affecting the individual response to ionizing radiation

AU - Averbeck, Dietrich

AU - Candéias, Serge

AU - Chandna, Sudhir

AU - Friedl, Anna A.

AU - Haghdoost, Siamak

AU - Jeggo, Penelope A.

AU - Lumniczky, Katalin

AU - Paris, Francois

AU - Quintens, Roel

AU - Sabatier, Laure

N1 - Score=10

PY - 2020/1/8

Y1 - 2020/1/8

N2 - Purpose: Humans are increasingly exposed to ionizing radiation (IR). Both low (<100 mGy) and high doses can cause stochastic effects, including cancer; whereas doses above 100 mGy are needed to promote tissue or cell damage. 10–15% of radiotherapy (RT) patients suffer adverse reactions, described as displaying radiosensitivity (RS). Sensitivity to IR’s stochastic effects is termed radiosusceptibility (RSu). To optimize radiation protection we need to understand the range of individual variability and underlying mechanisms. We review the potential mechanisms contribu-ting to RS/RSu focusing on RS following RT, the most tractable RS group. Conclusions: The IR-induced DNA damage response (DDR) has been well characterized. Patients with mutations in the DDR have been identified and display marked RS but they represent only a small percentage of the RT patients with adverse reactions. We review the impacting mechanisms and additional factors influencing RS/RSu. We discuss whether RS/RSu might be genetically deter-mined. As a recommendation, we propose that a prospective study be established to assess RS following RT. The study should detail tumor site and encompass a well-defined grading system. Predictive assays should be independently validated. Detailed analysis of the inflammatory, stress and immune responses, mitochondrial function and life style factors should be included. Existing cohorts should also be optimally exploited.

AB - Purpose: Humans are increasingly exposed to ionizing radiation (IR). Both low (<100 mGy) and high doses can cause stochastic effects, including cancer; whereas doses above 100 mGy are needed to promote tissue or cell damage. 10–15% of radiotherapy (RT) patients suffer adverse reactions, described as displaying radiosensitivity (RS). Sensitivity to IR’s stochastic effects is termed radiosusceptibility (RSu). To optimize radiation protection we need to understand the range of individual variability and underlying mechanisms. We review the potential mechanisms contribu-ting to RS/RSu focusing on RS following RT, the most tractable RS group. Conclusions: The IR-induced DNA damage response (DDR) has been well characterized. Patients with mutations in the DDR have been identified and display marked RS but they represent only a small percentage of the RT patients with adverse reactions. We review the impacting mechanisms and additional factors influencing RS/RSu. We discuss whether RS/RSu might be genetically deter-mined. As a recommendation, we propose that a prospective study be established to assess RS following RT. The study should detail tumor site and encompass a well-defined grading system. Predictive assays should be independently validated. Detailed analysis of the inflammatory, stress and immune responses, mitochondrial function and life style factors should be included. Existing cohorts should also be optimally exploited.

KW - Radiosensitivity

KW - Radiotherapy

KW - Radiation policy

KW - Radiation-induced cancer

KW - Radiosusceptibility

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/open/39183607

U2 - 10.1080/09553002.2019.1704908

DO - 10.1080/09553002.2019.1704908

M3 - Article

VL - 96

SP - 297

EP - 323

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

SN - 0955-3002

IS - 3

ER -

ID: 6842790