Extremity exposure in nuclear medicine therapy with 90Y-labelled substances – Results of the ORAMED project

Research output: Contribution to journalArticlepeer-review

Authors

  • A. Rimpler
  • I. Barth
  • Paolo Ferrari
  • Sebastien Baechler
  • Adela Carnicer
  • Laurent Donadille
  • M. Fulop
  • Mercè Ginjaume
  • M. Mariotti
  • Marta Sans-Mercé
  • G. Gualdrini
  • Sabah Krim
  • Xavier Ortega
  • Natasha Ruiz
  • Filip Vanhavere

Institutes & Expert groups

  • Bfs - Bundesamt Für Strahlenschutz - Federal Office for Radiation Protection
  • IRA - Institute of Radiation Physics, University Hospital of Lausanne
  • UPC - Universitat Politècnica de Catalunya
  • IRSN - Institute for Radioprotection and Nuclear Safety - Institut Radioprotection Sûreté Nucléaire
  • SMU - Slovak Medical University
  • ENEA - IRP - Institute Radiation Protection
  • ENEA - Italian National Agency for New Technologies

Documents & links

Abstract

90Y-labelled radiopharmaceuticals offer promising prospects for radionuclide therapies of tumours, e.g. radioimmunotherapies (RIT), (EANM, 2007), peptide receptor radiotherapies (PRRT), (Otte et al., 1998), and selective internal radiotherapies (SIRT), (Salem and Thurston, 2006). 90Y, an almost pure high-energy beta radiation emitter (Eβ,max = 2.28 MeV), is a favourable radionuclide for therapeutic purposes. However, when preparing and performing these therapies, high activities of 90Y (>1 GBq) are to be manipulated and technicians, physicians and nurses may receive high skin exposures to the hands. If radiation protection standards are low, the exposure of staff can exceed the annual skin dose limit of 500 mSv. Within a particular work package (WP4) of the ORAMED project, comprehensive measurements in nuclear medicine departments of several hospitals in 6 European countries were carried out. The study focussed on 90Y-labelled substances such as Zevalin® and DOTATOC to achieve a representative database on staff exposure. This paper summarises the most important results and conclusions for individual monitoring of skin exposure of staff.

Details

Original languageEnglish
Pages (from-to)1283-1286
JournalRadiation Measurements
Volume46
Issue number11
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Nuclear medicine, Radiation exposure, Skin dose, Individual monitoring

ID: 6869496