Ferrous Iron Is a Significant Component of Bioavailable Iron in Cystic Fibrosis Airways

Research output: Contribution to journalArticle

Authors

  • Ryan C. Hunter
  • Fadi Asfour
  • Jozef Dingemans
  • Brenda L. Osuna
  • Tahoura Samad
  • Anne Malfroot
  • Pierre Cornelis
  • Dianne K. Newman

Institutes & Expert groups

Documents & links

DOI

Abstract

Iron is an important environmental parameter that helps pathogens thrive in sites of infection, including those of cystic fibrosis (CF) patients. Ferric iron chelation therapy has been proposed as a novel therapeutic strategy for CF lung infections, yet until now, the iron oxidation state has not been measured in the host. In studying mucus from the infected lungs of multiple CF patients from Europe and the United States, we found that ferric and ferrous iron change in concentration and relative proportion as infections progress; over time, ferrous iron comes to dominate the iron pool. This information is relevant to the design of novel CF therapeutics and, more broadly, to developing accurate models of chronic CF infections.

Details

Original languageEnglish
Pages (from-to)1-8
JournalmBio
Volume4
Issue number4
DOIs
Publication statusPublished - Aug 2013

Keywords

  • iron, cystic fibrosis, Pseudomonas aeruginosa

ID: 133288