First report of cross resistance to silver and antibiotics in Klebsiella pneumoniae isolated from patients and polluted water in Tunisia

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First report of cross resistance to silver and antibiotics in Klebsiella pneumoniae isolated from patients and polluted water in Tunisia. / Ben Miloud, Samar; Ali, Md Muntasir; Boutiba Ben Boubaker, Ilhem; Van Houdt, Rob; Chouchani, Chedly.

In: Water and environment journal, Vol. 35, No. 2, 05.2021, p. 730-739.

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Ben Miloud, Samar ; Ali, Md Muntasir ; Boutiba Ben Boubaker, Ilhem ; Van Houdt, Rob ; Chouchani, Chedly. / First report of cross resistance to silver and antibiotics in Klebsiella pneumoniae isolated from patients and polluted water in Tunisia. In: Water and environment journal. 2021 ; Vol. 35, No. 2. pp. 730-739.

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@article{7fb4e8f523cd4385838fc453fb67e454,
title = "First report of cross resistance to silver and antibiotics in Klebsiella pneumoniae isolated from patients and polluted water in Tunisia",
abstract = "Klebsiella pneumoniae, ubiquitously found in a variety of environmental sources, is an important pathogen in burn wounds and nosocomial infections. Burn wounds have been commonly treated with silver compounds, which are also used in a multitude of (non)medical products. As the latter increased silver discharge into different environments, we evaluated and compared silver resistance in K. pneumoniae isolates collected from patients hospitalized at the Charles-Nicolle hospital (Tunis, Tunisia) with isolates collected from different metal polluted waters in the north and south of Tunisia. All K. pneumoniae isolates harboured blaTEM-1 and blaSHV-1. In addition, all clinical isolates showed a multidrug phenotype and harboured the blaCTX-M-15, blaOXA-1 and blaNDM-1. Furthermore, all isolates showed resistance to silver nitrate. The silver resistance determinant, screened via the silE gene, was located for all isolates on a large plasmid with a size similar to pMG101. This study showed cross-resistance between silver and beta-lactams in clinical as well as environmental K. pneumoniae isolates from Tunisia and showed for the first time that NDM-1-producing K. pneumoniae developed resistance to silver.",
keywords = "Antibiotic resistance, ESBLs, Klebsiella, Pneumoniae, SiLE, Silver resistance, Periplasmic, Binding protein siLE",
author = "{Ben Miloud}, Samar and Ali, {Md Muntasir} and {Boutiba Ben Boubaker}, Ilhem and {Van Houdt}, Rob and Chedly Chouchani",
note = "Score=10",
year = "2021",
month = may,
doi = "10.1111/wej.12665",
language = "English",
volume = "35",
pages = "730--739",
journal = "Water and environment journal",
issn = "1747-6585",
publisher = "Wiley",
number = "2",

}

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TY - JOUR

T1 - First report of cross resistance to silver and antibiotics in Klebsiella pneumoniae isolated from patients and polluted water in Tunisia

AU - Ben Miloud, Samar

AU - Ali, Md Muntasir

AU - Boutiba Ben Boubaker, Ilhem

AU - Van Houdt, Rob

AU - Chouchani, Chedly

N1 - Score=10

PY - 2021/5

Y1 - 2021/5

N2 - Klebsiella pneumoniae, ubiquitously found in a variety of environmental sources, is an important pathogen in burn wounds and nosocomial infections. Burn wounds have been commonly treated with silver compounds, which are also used in a multitude of (non)medical products. As the latter increased silver discharge into different environments, we evaluated and compared silver resistance in K. pneumoniae isolates collected from patients hospitalized at the Charles-Nicolle hospital (Tunis, Tunisia) with isolates collected from different metal polluted waters in the north and south of Tunisia. All K. pneumoniae isolates harboured blaTEM-1 and blaSHV-1. In addition, all clinical isolates showed a multidrug phenotype and harboured the blaCTX-M-15, blaOXA-1 and blaNDM-1. Furthermore, all isolates showed resistance to silver nitrate. The silver resistance determinant, screened via the silE gene, was located for all isolates on a large plasmid with a size similar to pMG101. This study showed cross-resistance between silver and beta-lactams in clinical as well as environmental K. pneumoniae isolates from Tunisia and showed for the first time that NDM-1-producing K. pneumoniae developed resistance to silver.

AB - Klebsiella pneumoniae, ubiquitously found in a variety of environmental sources, is an important pathogen in burn wounds and nosocomial infections. Burn wounds have been commonly treated with silver compounds, which are also used in a multitude of (non)medical products. As the latter increased silver discharge into different environments, we evaluated and compared silver resistance in K. pneumoniae isolates collected from patients hospitalized at the Charles-Nicolle hospital (Tunis, Tunisia) with isolates collected from different metal polluted waters in the north and south of Tunisia. All K. pneumoniae isolates harboured blaTEM-1 and blaSHV-1. In addition, all clinical isolates showed a multidrug phenotype and harboured the blaCTX-M-15, blaOXA-1 and blaNDM-1. Furthermore, all isolates showed resistance to silver nitrate. The silver resistance determinant, screened via the silE gene, was located for all isolates on a large plasmid with a size similar to pMG101. This study showed cross-resistance between silver and beta-lactams in clinical as well as environmental K. pneumoniae isolates from Tunisia and showed for the first time that NDM-1-producing K. pneumoniae developed resistance to silver.

KW - Antibiotic resistance

KW - ESBLs

KW - Klebsiella

KW - Pneumoniae

KW - SiLE

KW - Silver resistance

KW - Periplasmic

KW - Binding protein siLE

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/open/41515005

U2 - 10.1111/wej.12665

DO - 10.1111/wej.12665

M3 - Article

VL - 35

SP - 730

EP - 739

JO - Water and environment journal

JF - Water and environment journal

SN - 1747-6585

IS - 2

ER -

ID: 6978556