Generation of clinical 177Lu SPECT/CT images for dosimetry in MRT based on GATE Monte Carlo simulation

Research output: Contribution to report/book/conference proceedingsIn-proceedings paperpeer-review

Authors

Institutes & Expert groups

  • Inserm - French National Institute of Health and Medical Research
  • Université Toulouse III - Paul Sabatier
  • ICO - Institut de Cancérologie de l'Ouest,
  • Stellenbosch University - Tygerberg Hospital
  • IAEA - International Atomic Energy Agency

Documents & links

Abstract

Purpose Patient-specific dosimetry in MRT relies on quantitative imaging, pharmacokinetic assessment and absorbed dose calculation. The DosiTest project was initiated to evaluate the uncertainties associated with each step of the clinical dosimetry workflow through a virtual multicentric clinical trial. This work presents the generation of simulated clinical SPECT datasets based on GATE Monte Carlo modelling with its corresponding experimental CT image, which can subsequently be processed by commercial image workstations. Methods This study considers a therapy cycle of 6.85 GBq 177Lu-labelled DOTATATE derived from an IAEA-Coordinated Research Project (E23005) on “Dosimetry in Radiopharmaceutical therapy for personalised patient treatment”. Patient images were acquired on a GE Infinia-Hawkeye 4 gamma camera using a medium energy (ME) collimator. Simulated SPECT projections were generated based on experimental time points and validated against experimental SPECT projections using flattened profiles and gamma index. The simulated projections were then incorporated into the patient SPECT/CT DICOM envelopes for processing and their reconstruction within a commercial image workstation. Results Gamma index passing rate (2% − 1 pixel criteria) between 95 and 98% and average gamma between 0.28 and 0.35 among different time points revealed high similarity between simulated and experimental images. Image reconstruction of the simulated projections was successful on HERMES and Xeleris workstations, a major step forward for the initiation of a multicentric virtual clinical dosimetry trial based on simulated SPECT/CT images. Conclusions Realistic 177Lu patient SPECT projections were generated in GATE. These modelled datasets will be circulated to different clinical departments to perform dosimetry in order to assess the uncertainties in the entire dosimetric chain.

Details

Original languageEnglish
Title of host publicationJournal of nuclear medicine
PublisherSNMMI - Society of Nuclear Medicine and Molecular Imaging
Pages1-1
Number of pages1
Volume62
Edition1
Publication statusPublished - 18 May 2021
Event2021 - SNMMI - Online, United States
Duration: 11 Jun 202115 Jun 2021
https://jnm.snmjournals.org/content/62/supplement_1/1587

Publication series

NameJournal of Nuclear Medicine
PublisherSociety of Nuclear Medicine
NumberS1
Volume62
ISSN (Print)0161-5505
ISSN (Electronic)2159-662X

Conference

Conference2021 - SNMMI
Country/TerritoryUnited States
Period2021-06-112021-06-15
Internet address

Keywords

  • Clinical dosimetry, DosiTest, SPECT/CT, GATE Monte Carlo modelling

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