Genrisk-T project: response of the TPC-1 papillary thyroid carcinoma cell line to a range of low to high doses of irradiation

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Genrisk-T project: response of the TPC-1 papillary thyroid carcinoma cell line to a range of low to high doses of irradiation. / Abouelaradat, Khalil; Derradji, Hanane; Bekaert, Sofie; De Meyer, Tim; van Criekinge, Wim; Baatout, Sarah; Jacquet, Paul (Peer reviewer).

In: Communications in agricultural and applied biological sciences, Vol. 73, No. 1, 15.09.2008, p. 79-83.

Research output: Contribution to journalArticle

Harvard

Abouelaradat, K, Derradji, H, Bekaert, S, De Meyer, T, van Criekinge, W, Baatout, S & Jacquet, P 2008, 'Genrisk-T project: response of the TPC-1 papillary thyroid carcinoma cell line to a range of low to high doses of irradiation', Communications in agricultural and applied biological sciences, vol. 73, no. 1, pp. 79-83.

APA

Abouelaradat, K., Derradji, H., Bekaert, S., De Meyer, T., van Criekinge, W., Baatout, S., & Jacquet, P. (2008). Genrisk-T project: response of the TPC-1 papillary thyroid carcinoma cell line to a range of low to high doses of irradiation. Communications in agricultural and applied biological sciences, 73(1), 79-83.

Vancouver

Abouelaradat K, Derradji H, Bekaert S, De Meyer T, van Criekinge W, Baatout S et al. Genrisk-T project: response of the TPC-1 papillary thyroid carcinoma cell line to a range of low to high doses of irradiation. Communications in agricultural and applied biological sciences. 2008 Sep 15;73(1):79-83.

Author

Abouelaradat, Khalil ; Derradji, Hanane ; Bekaert, Sofie ; De Meyer, Tim ; van Criekinge, Wim ; Baatout, Sarah ; Jacquet, Paul. / Genrisk-T project: response of the TPC-1 papillary thyroid carcinoma cell line to a range of low to high doses of irradiation. In: Communications in agricultural and applied biological sciences. 2008 ; Vol. 73, No. 1. pp. 79-83.

Bibtex - Download

@article{a7ccdfe512094390a728a175f6df831e,
title = "Genrisk-T project: response of the TPC-1 papillary thyroid carcinoma cell line to a range of low to high doses of irradiation",
abstract = "Our results indicate that TPC-1 cells do not undergo significant cell death but are more prone to cell cycle arrest in response to external X-irradiation. Only a small percentage of irradiated TPC-1 cells underwent apoptosis or necrosis in response to irradiation after 24 and 48 hours. On the other hand, the same cells showed a great decrease in the S phase of the cell cycle, which translates as a decrease in proliferation. Examination of the morphology of irradiated TPC-1 cells showed signs of apoptosis and cellular damage in some of the cells at 24 and 48 hours. In conclusion, our results indicate that irradiation of a human papillary thyroid carcinoma cell line, TPC-1, causes a decrease in cells in the S phase of the cell cycle through activation of the G1/S checkpoint probably caused by an increase in the translational activity of p53 through p21. Apoptosis and necrosis seem not to play as important a role in these cells' response to X-irradiation.",
keywords = "TPC-1, Papillary Thyroid Carcinoma, Apoptosis, Caspase-3, Bcl-2, p53, radiation, flow cytometry, proliferation",
author = "Khalil Abouelaradat and Hanane Derradji and Sofie Bekaert and {De Meyer}, Tim and {van Criekinge}, Wim and Sarah Baatout and Paul Jacquet",
note = "Score = 2",
year = "2008",
month = "9",
day = "15",
language = "English",
volume = "73",
pages = "79--83",
journal = "Communications in agricultural and applied biological sciences",
issn = "1379-1176",
publisher = "UGent - Universiteit Gent",
number = "1",

}

RIS - Download

TY - JOUR

T1 - Genrisk-T project: response of the TPC-1 papillary thyroid carcinoma cell line to a range of low to high doses of irradiation

AU - Abouelaradat, Khalil

AU - Derradji, Hanane

AU - Bekaert, Sofie

AU - De Meyer, Tim

AU - van Criekinge, Wim

AU - Baatout, Sarah

A2 - Jacquet, Paul

N1 - Score = 2

PY - 2008/9/15

Y1 - 2008/9/15

N2 - Our results indicate that TPC-1 cells do not undergo significant cell death but are more prone to cell cycle arrest in response to external X-irradiation. Only a small percentage of irradiated TPC-1 cells underwent apoptosis or necrosis in response to irradiation after 24 and 48 hours. On the other hand, the same cells showed a great decrease in the S phase of the cell cycle, which translates as a decrease in proliferation. Examination of the morphology of irradiated TPC-1 cells showed signs of apoptosis and cellular damage in some of the cells at 24 and 48 hours. In conclusion, our results indicate that irradiation of a human papillary thyroid carcinoma cell line, TPC-1, causes a decrease in cells in the S phase of the cell cycle through activation of the G1/S checkpoint probably caused by an increase in the translational activity of p53 through p21. Apoptosis and necrosis seem not to play as important a role in these cells' response to X-irradiation.

AB - Our results indicate that TPC-1 cells do not undergo significant cell death but are more prone to cell cycle arrest in response to external X-irradiation. Only a small percentage of irradiated TPC-1 cells underwent apoptosis or necrosis in response to irradiation after 24 and 48 hours. On the other hand, the same cells showed a great decrease in the S phase of the cell cycle, which translates as a decrease in proliferation. Examination of the morphology of irradiated TPC-1 cells showed signs of apoptosis and cellular damage in some of the cells at 24 and 48 hours. In conclusion, our results indicate that irradiation of a human papillary thyroid carcinoma cell line, TPC-1, causes a decrease in cells in the S phase of the cell cycle through activation of the G1/S checkpoint probably caused by an increase in the translational activity of p53 through p21. Apoptosis and necrosis seem not to play as important a role in these cells' response to X-irradiation.

KW - TPC-1

KW - Papillary Thyroid Carcinoma

KW - Apoptosis

KW - Caspase-3

KW - Bcl-2

KW - p53

KW - radiation

KW - flow cytometry

KW - proliferation

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_91429

UR - http://knowledgecentre.sckcen.be/so2/bibref/5167

M3 - Article

VL - 73

SP - 79

EP - 83

JO - Communications in agricultural and applied biological sciences

JF - Communications in agricultural and applied biological sciences

SN - 1379-1176

IS - 1

ER -

ID: 339107