Gold nanoparticles coated with antibodies lead to ROSdependent apoptotic cell death in non-cancerous human cell lines

Research output: Contribution to journalSpecial issue

Authors

Institutes & Expert groups

  • UNamur - University of Namur

Documents & links

Abstract

In cancer radiotherapy, gold nanoparticles (AuNPs) have emerged as promising radiosensitizers increasing the effectiveness of external beam radiotherapy by local production of reactive oxygen species (ROS) and secondary electrons upon irradiation. At UNamur, 5 nm gold nanoparticles coated with an organic shell of polyallylamine are produced by plasma vapor deposition (AuNPs@PPAA). Optionally, the AuNPs@PPAA can be conjugated to anti-EGFR antibodies (Cetuximab) (AuNPs@PPAACtxb) which actively target EGFR-overexpressing cancer cells in vitro and in vivo.

Details

Original languageEnglish
Article numberEP-0871
Pages (from-to)S653
Number of pages1
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume45
DOIs
Publication statusPublished - 31 Dec 2018
Event2018 - Annual congress of the European association of Nuclear medicine - Dusseldorf, Germany
Duration: 13 Oct 201817 Oct 2018

Keywords

  • Nanoparticles, Cancer Radiotherapy, Anti-bodies, In-vivo

ID: 6772892