Gold nanoparticles coated with antibodies lead to ROSdependent apoptotic cell death in non-cancerous human cell lines
Research output: Contribution to report/book/conference proceedings › In-proceedings paper › peer-review
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DOI
Abstract
In cancer radiotherapy, gold nanoparticles (AuNPs) have emerged as promising radiosensitizers increasing the effectiveness of external beam radiotherapy by local production of reactive oxygen species (ROS) and secondary electrons upon irradiation. At UNamur, 5 nm gold nanoparticles coated with an organic shell of polyallylamine are produced by plasma vapor deposition (AuNPs@PPAA). Optionally, the AuNPs@PPAA can be conjugated to anti-EGFR antibodies (Cetuximab) (AuNPs@PPAACtxb) which actively target EGFR-overexpressing cancer cells in vitro and in vivo.
Details
| Original language | English |
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| Title of host publication | Annual Congress of the European Association of Nuclear Medicine October 13 – 17, 2018 Düsseldorf, Germany |
| Pages | S653 |
| Number of pages | 1 |
| Volume | 45 |
| DOIs | |
| Publication status | Published - 31 Dec 2018 |
| Event | 2018 - Annual congress of the European association of Nuclear medicine - Dusseldorf, Germany Duration: 13 Oct 2018 → 17 Oct 2018 |
Publication series
| Name | European Journal of Nuclear Medicine and Molecular Imaging |
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| Publisher | Springer |
| ISSN (Print) | 1619-7070 |
Conference
| Conference | 2018 - Annual congress of the European association of Nuclear medicine |
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| Country/Territory | Germany |
| City | Dusseldorf |
| Period | 2018-10-13 → 2018-10-17 |
Keywords
- Nanoparticles, Cancer Radiotherapy, Anti-bodies, In-vivo
ID: 7323810