Gold nanoparticles meet medical radionuclides

Research output: Contribution to journalArticle

Authors

Institutes & Expert groups

  • UNamur - University of Namur

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Abstract

Thanks to their unique optical and physicochemical properties, gold nanoparticles have gained increased interest as radiosensitizing, photothermal therapy and optical imaging agents to enhance the effectiveness of cancer detection and therapy. Furthermore, their ability to carry multiple medically relevant radionuclides broadens their use to nuclear medicine SPECT and PET imaging as well as targeted radionuclide therapy. In this review, we discuss the radiolabeling process of gold nanoparticles and their use in (multimodal) nuclear medicine imaging to better understand their specific distribution, uptake and retention in different in vivo cancer models. In addition, radiolabeled gold nanoparticles enable image-guided therapy is reviewed aswell as the enhancement of targeted radionuclide therapy and nanobrachytherapy through an increased dose deposition and radiosensitization, as demonstrated by multiple Monte Carlo studies and experimental in vitro and in vivo studies.

Details

Original languageEnglish
Pages (from-to)61-90
Number of pages30
JournalNuclear Medicine and Biology
Volume100-101
DOIs
Publication statusPublished - 1 Sep 2021

Keywords

  • Radiosensitization, Dose enhancement, Targeted radionuclide therapy, Cancer theranostics, Nuclear medicine, Nanobrachytherapy

ID: 7164638