Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis

Research output: Contribution to journalArticlepeer-review

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Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis. / Huin-Schohn, Cécile; Guéguinou, Nathan; Schenten, Véronique; Bascove, Matthieu; Gauquelin Koch, Guillemette; Baatout, Sarah; Tschirhart, Eric; Frippiat, Jean-Pol; Moreels, Marjan (Peer reviewer).

In: The FASEB Journal, Vol. 27, No. 1, 01.2013, p. 333-341.

Research output: Contribution to journalArticlepeer-review

Harvard

Huin-Schohn, C, Guéguinou, N, Schenten, V, Bascove, M, Gauquelin Koch, G, Baatout, S, Tschirhart, E, Frippiat, J-P & Moreels, M 2013, 'Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis', The FASEB Journal, vol. 27, no. 1, pp. 333-341. https://doi.org/10.1096/fj.12-217547

APA

Huin-Schohn, C., Guéguinou, N., Schenten, V., Bascove, M., Gauquelin Koch, G., Baatout, S., Tschirhart, E., Frippiat, J-P., & Moreels, M. (2013). Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis. The FASEB Journal, 27(1), 333-341. https://doi.org/10.1096/fj.12-217547

Vancouver

Huin-Schohn C, Guéguinou N, Schenten V, Bascove M, Gauquelin Koch G, Baatout S et al. Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis. The FASEB Journal. 2013 Jan;27(1):333-341. https://doi.org/10.1096/fj.12-217547

Author

Huin-Schohn, Cécile ; Guéguinou, Nathan ; Schenten, Véronique ; Bascove, Matthieu ; Gauquelin Koch, Guillemette ; Baatout, Sarah ; Tschirhart, Eric ; Frippiat, Jean-Pol ; Moreels, Marjan. / Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis. In: The FASEB Journal. 2013 ; Vol. 27, No. 1. pp. 333-341.

Bibtex - Download

@article{99e6188dac234581933831e582119f96,
title = "Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis",
abstract = "Our previous research demonstrated that spaceflight conditions affect antibody production in response to an antigenic stimulation in adult amphibians. Here, we investigated whether antibody synthesis is affected when animal development occurs onboard a space station. To answer this question, embryos of the Iberian ribbed newt, Pleurodeles waltl, were sent to the International Space Station (ISS) before the initiation of immunoglobulin heavy-chain expression. Thus, antibody synthesis began in space. On landing, we determined the effects of spaceflight on P. waltl development and IgM heavy-chain transcription. Results were compared with those obtained using embryos that developed on Earth. We find that IgM heavy-chain transcription is doubled at landing and that spaceflight does not affect P. waltl development and does not induce inflammation. We also recreated the environmental modifications encountered by the embryos during their development onboard the ISS. This strategy allowed us to demonstrate that gravity change is the factor responsible for antibody heavy-chain transcription modifications that are associated with NF-_B mRNA level variations. Taken together, and given that the larvae were not immunized, these data suggest a modification of lymphopoiesis when gravity changes occur during ontogeny.",
keywords = "humoral immune system, antibody, B lymphocyte",
author = "C{\'e}cile Huin-Schohn and Nathan Gu{\'e}guinou and V{\'e}ronique Schenten and Matthieu Bascove and {Gauquelin Koch}, Guillemette and Sarah Baatout and Eric Tschirhart and Jean-Pol Frippiat and Marjan Moreels",
note = "Score = 10",
year = "2013",
month = jan,
doi = "10.1096/fj.12-217547",
language = "English",
volume = "27",
pages = "333--341",
journal = "The FASEB Journal",
issn = "0892-6638",
publisher = "FASEB - Federation of American Society of Experimental Biology",
number = "1",

}

RIS - Download

TY - JOUR

T1 - Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis

AU - Huin-Schohn, Cécile

AU - Guéguinou, Nathan

AU - Schenten, Véronique

AU - Bascove, Matthieu

AU - Gauquelin Koch, Guillemette

AU - Baatout, Sarah

AU - Tschirhart, Eric

AU - Frippiat, Jean-Pol

A2 - Moreels, Marjan

N1 - Score = 10

PY - 2013/1

Y1 - 2013/1

N2 - Our previous research demonstrated that spaceflight conditions affect antibody production in response to an antigenic stimulation in adult amphibians. Here, we investigated whether antibody synthesis is affected when animal development occurs onboard a space station. To answer this question, embryos of the Iberian ribbed newt, Pleurodeles waltl, were sent to the International Space Station (ISS) before the initiation of immunoglobulin heavy-chain expression. Thus, antibody synthesis began in space. On landing, we determined the effects of spaceflight on P. waltl development and IgM heavy-chain transcription. Results were compared with those obtained using embryos that developed on Earth. We find that IgM heavy-chain transcription is doubled at landing and that spaceflight does not affect P. waltl development and does not induce inflammation. We also recreated the environmental modifications encountered by the embryos during their development onboard the ISS. This strategy allowed us to demonstrate that gravity change is the factor responsible for antibody heavy-chain transcription modifications that are associated with NF-_B mRNA level variations. Taken together, and given that the larvae were not immunized, these data suggest a modification of lymphopoiesis when gravity changes occur during ontogeny.

AB - Our previous research demonstrated that spaceflight conditions affect antibody production in response to an antigenic stimulation in adult amphibians. Here, we investigated whether antibody synthesis is affected when animal development occurs onboard a space station. To answer this question, embryos of the Iberian ribbed newt, Pleurodeles waltl, were sent to the International Space Station (ISS) before the initiation of immunoglobulin heavy-chain expression. Thus, antibody synthesis began in space. On landing, we determined the effects of spaceflight on P. waltl development and IgM heavy-chain transcription. Results were compared with those obtained using embryos that developed on Earth. We find that IgM heavy-chain transcription is doubled at landing and that spaceflight does not affect P. waltl development and does not induce inflammation. We also recreated the environmental modifications encountered by the embryos during their development onboard the ISS. This strategy allowed us to demonstrate that gravity change is the factor responsible for antibody heavy-chain transcription modifications that are associated with NF-_B mRNA level variations. Taken together, and given that the larvae were not immunized, these data suggest a modification of lymphopoiesis when gravity changes occur during ontogeny.

KW - humoral immune system

KW - antibody

KW - B lymphocyte

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_127635

UR - http://knowledgecentre.sckcen.be/so2/bibref/10048

U2 - 10.1096/fj.12-217547

DO - 10.1096/fj.12-217547

M3 - Article

VL - 27

SP - 333

EP - 341

JO - The FASEB Journal

JF - The FASEB Journal

SN - 0892-6638

IS - 1

ER -

ID: 122197