Growing blood vessels in space: The SPHEROIDS project

Research output: Contribution to report/book/conference proceedingsIn-proceedings paper

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Growing blood vessels in space : The SPHEROIDS project. / Krüger, Marcus; Kopp, Sascha; Wehland, Markus; Bauer, Johann; Baatout, Sarah; Moreels, Marjan; Egli, Marcel; Corydon, Thomas J.; Infanger, Manfred; Grimm, Daniela.

69th International astronautical congres - IAC 2018. Vol. 1 2018. ed. Curran Associates, Inc., 2019. p. 652-660.

Research output: Contribution to report/book/conference proceedingsIn-proceedings paper

Harvard

Krüger, M, Kopp, S, Wehland, M, Bauer, J, Baatout, S, Moreels, M, Egli, M, Corydon, TJ, Infanger, M & Grimm, D 2019, Growing blood vessels in space: The SPHEROIDS project. in 69th International astronautical congres - IAC 2018. 2018 edn, vol. 1, Curran Associates, Inc., pp. 652-660, AIC 2018 - 69th International astronautical congres, Bremen, Germany, 2018-10-01.

APA

Krüger, M., Kopp, S., Wehland, M., Bauer, J., Baatout, S., Moreels, M., ... Grimm, D. (2019). Growing blood vessels in space: The SPHEROIDS project. In 69th International astronautical congres - IAC 2018 (2018 ed., Vol. 1, pp. 652-660). Curran Associates, Inc..

Vancouver

Krüger M, Kopp S, Wehland M, Bauer J, Baatout S, Moreels M et al. Growing blood vessels in space: The SPHEROIDS project. In 69th International astronautical congres - IAC 2018. 2018 ed. Vol. 1. Curran Associates, Inc. 2019. p. 652-660

Author

Krüger, Marcus ; Kopp, Sascha ; Wehland, Markus ; Bauer, Johann ; Baatout, Sarah ; Moreels, Marjan ; Egli, Marcel ; Corydon, Thomas J. ; Infanger, Manfred ; Grimm, Daniela. / Growing blood vessels in space : The SPHEROIDS project. 69th International astronautical congres - IAC 2018. Vol. 1 2018. ed. Curran Associates, Inc., 2019. pp. 652-660

Bibtex - Download

@inproceedings{3bfd91435c8846b1a0805949f7a56464,
title = "Growing blood vessels in space: The SPHEROIDS project",
abstract = "Under normal culture conditions endothelial cells (ECs) grow as single layers on the bottom surface of cell culture flasks. In numerous experiments using simulated microgravity we noticed that the ECs formed three-dimensional, tube-like cell aggregates resembling the intima of small, rudimentary blood vessels. The SPHEROIDS project has now shown that similar processes occur in space. For the first time, we could observe scaffold-free growth of human ECs into multicellular spheroids and tubular structures during an experiment in real microgravity. With further investigation of the space samples we hope to understand endothelial 3D growth and to improve the in vitro engineering of biocompatible vessels which could be used in surgery.",
keywords = "Microgravity, Spaceflight, Random positioning machine, 3D growth, Spheroids, Tubular structures",
author = "Marcus Kr{\"u}ger and Sascha Kopp and Markus Wehland and Johann Bauer and Sarah Baatout and Marjan Moreels and Marcel Egli and Corydon, {Thomas J.} and Manfred Infanger and Daniela Grimm",
note = "Score=3",
year = "2019",
month = "4",
language = "English",
isbn = "9781510881655",
volume = "1",
pages = "652--660",
booktitle = "69th International astronautical congres - IAC 2018",
publisher = "Curran Associates, Inc.",
address = "United States",
edition = "2018",

}

RIS - Download

TY - GEN

T1 - Growing blood vessels in space

T2 - The SPHEROIDS project

AU - Krüger, Marcus

AU - Kopp, Sascha

AU - Wehland, Markus

AU - Bauer, Johann

AU - Baatout, Sarah

AU - Moreels, Marjan

AU - Egli, Marcel

AU - Corydon, Thomas J.

AU - Infanger, Manfred

AU - Grimm, Daniela

N1 - Score=3

PY - 2019/4

Y1 - 2019/4

N2 - Under normal culture conditions endothelial cells (ECs) grow as single layers on the bottom surface of cell culture flasks. In numerous experiments using simulated microgravity we noticed that the ECs formed three-dimensional, tube-like cell aggregates resembling the intima of small, rudimentary blood vessels. The SPHEROIDS project has now shown that similar processes occur in space. For the first time, we could observe scaffold-free growth of human ECs into multicellular spheroids and tubular structures during an experiment in real microgravity. With further investigation of the space samples we hope to understand endothelial 3D growth and to improve the in vitro engineering of biocompatible vessels which could be used in surgery.

AB - Under normal culture conditions endothelial cells (ECs) grow as single layers on the bottom surface of cell culture flasks. In numerous experiments using simulated microgravity we noticed that the ECs formed three-dimensional, tube-like cell aggregates resembling the intima of small, rudimentary blood vessels. The SPHEROIDS project has now shown that similar processes occur in space. For the first time, we could observe scaffold-free growth of human ECs into multicellular spheroids and tubular structures during an experiment in real microgravity. With further investigation of the space samples we hope to understand endothelial 3D growth and to improve the in vitro engineering of biocompatible vessels which could be used in surgery.

KW - Microgravity

KW - Spaceflight

KW - Random positioning machine

KW - 3D growth

KW - Spheroids

KW - Tubular structures

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/overview/39624518

M3 - In-proceedings paper

SN - 9781510881655

VL - 1

SP - 652

EP - 660

BT - 69th International astronautical congres - IAC 2018

PB - Curran Associates, Inc.

ER -

ID: 6896285