Growing blood vessels in space: Preparation studies of the SPHEROIDS project using related ground-based studies

Research output: Contribution to journal › Article › peer-review

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Growing blood vessels in space: Preparation studies of the SPHEROIDS project using related ground-based studies. / Krüger, Marcus; Kopp, Sascha; Wehland, Markus; Bauer, Johann; Baatout, Sarah; Moreels, Marjan; Egli, Marcel; Corydon, Thomas J.; Infanger, Manfred; Grimm, Daniela.

In: Acta Astronautica, Vol. 159, 21.03.2019, p. 267–272.

Research output: Contribution to journal › Article › peer-review

Harvard

Krüger, M, Kopp, S, Wehland, M, Bauer, J, Baatout, S, Moreels, M, Egli, M, Corydon, TJ, Infanger, M & Grimm, D 2019, 'Growing blood vessels in space: Preparation studies of the SPHEROIDS project using related ground-based studies', Acta Astronautica, vol. 159, pp. 267–272. https://doi.org/10.1016/j.actaastro.2019.03.074

APA

Krüger, M., Kopp, S., Wehland, M., Bauer, J., Baatout, S., Moreels, M., Egli, M., Corydon, T. J., Infanger, M., & Grimm, D. (2019). Growing blood vessels in space: Preparation studies of the SPHEROIDS project using related ground-based studies. Acta Astronautica, 159, 267–272. https://doi.org/10.1016/j.actaastro.2019.03.074

Vancouver

Krüger M, Kopp S, Wehland M, Bauer J, Baatout S, Moreels M et al. Growing blood vessels in space: Preparation studies of the SPHEROIDS project using related ground-based studies. Acta Astronautica. 2019 Mar 21;159:267–272. https://doi.org/10.1016/j.actaastro.2019.03.074

Author

Krüger, Marcus ; Kopp, Sascha ; Wehland, Markus ; Bauer, Johann ; Baatout, Sarah ; Moreels, Marjan ; Egli, Marcel ; Corydon, Thomas J. ; Infanger, Manfred ; Grimm, Daniela. / Growing blood vessels in space: Preparation studies of the SPHEROIDS project using related ground-based studies. In: Acta Astronautica. 2019 ; Vol. 159. pp. 267–272.

Bibtex - Download

@article{8856e3bbd4b14fbc9316e9bfb65621e3,
title = "Growing blood vessels in space: Preparation studies of the SPHEROIDS project using related ground-based studies",
abstract = "Endothelial cells (ECs) grow as single layers on the bottom surface of cell culture flasks under normal (1g) culture conditions. In numerous experiments using simulated microgravity we noticed that the ECs formed three-dimensional, tube-like cell aggregates resembling the intima of small, rudimentary blood vessels. The SPHEROIDS project has now shown that similar processes occur in space. For the first time, we were able to observe scaffoldfree growth of human ECs into multicellular spheroids and tubular structures during an experiment in real microgravity. With further investigation of the space samples we hope to understand endothelial 3D growth and to improve the in vitro engineering of biocompatible vessels which could be used in surgery.",
keywords = "Microgravity, Spaceflight, Random positioning machine, 3D growth, Spheroids, Tubular structures",
author = "Marcus Kr{\"u}ger and Sascha Kopp and Markus Wehland and Johann Bauer and Sarah Baatout and Marjan Moreels and Marcel Egli and Corydon, {Thomas J.} and Manfred Infanger and Daniela Grimm",
note = "Score=10",
year = "2019",
month = mar,
day = "21",
doi = "10.1016/j.actaastro.2019.03.074",
language = "English",
volume = "159",
pages = "267–272",
journal = "Acta Astronautica",
issn = "0094-5765",
publisher = "Elsevier",

}

RIS - Download

TY - JOUR

T1 - Growing blood vessels in space: Preparation studies of the SPHEROIDS project using related ground-based studies

AU - Krüger, Marcus

AU - Kopp, Sascha

AU - Wehland, Markus

AU - Bauer, Johann

AU - Baatout, Sarah

AU - Moreels, Marjan

AU - Egli, Marcel

AU - Corydon, Thomas J.

AU - Infanger, Manfred

AU - Grimm, Daniela

N1 - Score=10

PY - 2019/3/21

Y1 - 2019/3/21

N2 - Endothelial cells (ECs) grow as single layers on the bottom surface of cell culture flasks under normal (1g) culture conditions. In numerous experiments using simulated microgravity we noticed that the ECs formed three-dimensional, tube-like cell aggregates resembling the intima of small, rudimentary blood vessels. The SPHEROIDS project has now shown that similar processes occur in space. For the first time, we were able to observe scaffoldfree growth of human ECs into multicellular spheroids and tubular structures during an experiment in real microgravity. With further investigation of the space samples we hope to understand endothelial 3D growth and to improve the in vitro engineering of biocompatible vessels which could be used in surgery.

AB - Endothelial cells (ECs) grow as single layers on the bottom surface of cell culture flasks under normal (1g) culture conditions. In numerous experiments using simulated microgravity we noticed that the ECs formed three-dimensional, tube-like cell aggregates resembling the intima of small, rudimentary blood vessels. The SPHEROIDS project has now shown that similar processes occur in space. For the first time, we were able to observe scaffoldfree growth of human ECs into multicellular spheroids and tubular structures during an experiment in real microgravity. With further investigation of the space samples we hope to understand endothelial 3D growth and to improve the in vitro engineering of biocompatible vessels which could be used in surgery.

KW - Microgravity

KW - Spaceflight

KW - Random positioning machine

KW - 3D growth

KW - Spheroids

KW - Tubular structures

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/33502472

U2 - 10.1016/j.actaastro.2019.03.074

DO - 10.1016/j.actaastro.2019.03.074

M3 - Article

VL - 159

SP - 267

EP - 272

JO - Acta Astronautica

JF - Acta Astronautica

SN - 0094-5765

ER -

ID: 5034825