Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL3

Research output: Contribution to journalArticlepeer-review


  • J. Abello
  • C. Damien
  • P. Robberecht
  • Robert Hooghe
  • André Vandermeers
  • Marie-Claire Vandermeers-Piret
  • J. Christophe

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  • ULB - Université Libre de Bruxelles

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1 Functional vasoactive intestinal peptide (VIP)/helodermin receptors and β2‐adrenoceptors coexist in membranes from a cultured cloned BL/VL3 cell line of murine T‐cell lymphoma induced by a radiation leukemia virus (see preceding paper in this journal).

2 Short‐term (5–30 min) exposures of BL/VL3 cells to VIP or isoproterenol induced both homologous and heterologous desensitization. The potency of VIP and isoproterenol to desensitize was similar to their potency to occupy receptors and activate adenylate cyclase.

3 Long‐term (16‐h) exposure of BL/VL3 cells to VIP induced homologous down regulation only, whereas isoproterenol induced both homologous and heterologous down regulation. The potency of VIP, peptide histidine isoleucinamide, helodermin, helospectin, and [D‐Phe2]VIP on the one hand, and of isoproterenol on the other hand, to decrease homologous responses was comparable to their potency for receptor occupancy and adenylate cyclase activation.


Original languageEnglish
Pages (from-to)269-274
Number of pages6
JournalEuropean Journal of Biochemistry
Issue number2
Publication statusPublished - 1 Aug 1989


  • vasoactive‐intestinal‐peptide, Homologous and heterologous regulation, BL/VL3, leukemia‐virus‐induced

ID: 4799367