Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL3

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Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL3. / Abello, J.; Damien, C.; Robberecht, P.; Hooghe, Robert; Vandermeers, André; Vandermeers-Piret, Marie-Claire ; Christophe, J.

In: European Journal of Biochemistry, Vol. 183, No. 2, 01.08.1989, p. 269-274.

Research output: Contribution to journalArticle

Harvard

Abello, J, Damien, C, Robberecht, P, Hooghe, R, Vandermeers, A, Vandermeers-Piret, M-C & Christophe, J 1989, 'Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL3', European Journal of Biochemistry, vol. 183, no. 2, pp. 269-274. https://doi.org/10.1111/j.1432-1033.1989.tb14923.x

APA

Abello, J., Damien, C., Robberecht, P., Hooghe, R., Vandermeers, A., Vandermeers-Piret, M-C., & Christophe, J. (1989). Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL3. European Journal of Biochemistry, 183(2), 269-274. https://doi.org/10.1111/j.1432-1033.1989.tb14923.x

Author

Abello, J. ; Damien, C. ; Robberecht, P. ; Hooghe, Robert ; Vandermeers, André ; Vandermeers-Piret, Marie-Claire ; Christophe, J. / Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL3. In: European Journal of Biochemistry. 1989 ; Vol. 183, No. 2. pp. 269-274.

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@article{19cacb352c9743fbbfb52659c0127088,
title = "Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL3",
abstract = "1 Functional vasoactive intestinal peptide (VIP)/helodermin receptors and β2‐adrenoceptors coexist in membranes from a cultured cloned BL/VL3 cell line of murine T‐cell lymphoma induced by a radiation leukemia virus (see preceding paper in this journal). 2 Short‐term (5–30 min) exposures of BL/VL3 cells to VIP or isoproterenol induced both homologous and heterologous desensitization. The potency of VIP and isoproterenol to desensitize was similar to their potency to occupy receptors and activate adenylate cyclase. 3 Long‐term (16‐h) exposure of BL/VL3 cells to VIP induced homologous down regulation only, whereas isoproterenol induced both homologous and heterologous down regulation. The potency of VIP, peptide histidine isoleucinamide, helodermin, helospectin, and [D‐Phe2]VIP on the one hand, and of isoproterenol on the other hand, to decrease homologous responses was comparable to their potency for receptor occupancy and adenylate cyclase activation.",
keywords = "vasoactive‐intestinal‐peptide, Homologous and heterologous regulation, BL/VL3, leukemia‐virus‐induced",
author = "J. Abello and C. Damien and P. Robberecht and Robert Hooghe and Andr{\'e} Vandermeers and Marie-Claire Vandermeers-Piret and J. Christophe",
year = "1989",
month = "8",
day = "1",
doi = "10.1111/j.1432-1033.1989.tb14923.x",
language = "English",
volume = "183",
pages = "269--274",
journal = "European Journal of Biochemistry",
issn = "0014-2956",
publisher = "Wiley - John Wiley & Sons, Ltd",
number = "2",

}

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TY - JOUR

T1 - Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL3

AU - Abello, J.

AU - Damien, C.

AU - Robberecht, P.

AU - Hooghe, Robert

AU - Vandermeers, André

AU - Vandermeers-Piret, Marie-Claire

AU - Christophe, J.

PY - 1989/8/1

Y1 - 1989/8/1

N2 - 1 Functional vasoactive intestinal peptide (VIP)/helodermin receptors and β2‐adrenoceptors coexist in membranes from a cultured cloned BL/VL3 cell line of murine T‐cell lymphoma induced by a radiation leukemia virus (see preceding paper in this journal). 2 Short‐term (5–30 min) exposures of BL/VL3 cells to VIP or isoproterenol induced both homologous and heterologous desensitization. The potency of VIP and isoproterenol to desensitize was similar to their potency to occupy receptors and activate adenylate cyclase. 3 Long‐term (16‐h) exposure of BL/VL3 cells to VIP induced homologous down regulation only, whereas isoproterenol induced both homologous and heterologous down regulation. The potency of VIP, peptide histidine isoleucinamide, helodermin, helospectin, and [D‐Phe2]VIP on the one hand, and of isoproterenol on the other hand, to decrease homologous responses was comparable to their potency for receptor occupancy and adenylate cyclase activation.

AB - 1 Functional vasoactive intestinal peptide (VIP)/helodermin receptors and β2‐adrenoceptors coexist in membranes from a cultured cloned BL/VL3 cell line of murine T‐cell lymphoma induced by a radiation leukemia virus (see preceding paper in this journal). 2 Short‐term (5–30 min) exposures of BL/VL3 cells to VIP or isoproterenol induced both homologous and heterologous desensitization. The potency of VIP and isoproterenol to desensitize was similar to their potency to occupy receptors and activate adenylate cyclase. 3 Long‐term (16‐h) exposure of BL/VL3 cells to VIP induced homologous down regulation only, whereas isoproterenol induced both homologous and heterologous down regulation. The potency of VIP, peptide histidine isoleucinamide, helodermin, helospectin, and [D‐Phe2]VIP on the one hand, and of isoproterenol on the other hand, to decrease homologous responses was comparable to their potency for receptor occupancy and adenylate cyclase activation.

KW - vasoactive‐intestinal‐peptide

KW - Homologous and heterologous regulation

KW - BL/VL3

KW - leukemia‐virus‐induced

UR - https://ecm.sckcen.be/OTCS/llisapi.dll?func=ll&objaction=overview&objid=32614388&logStopConditionID=230368_87371813_1_open

U2 - 10.1111/j.1432-1033.1989.tb14923.x

DO - 10.1111/j.1432-1033.1989.tb14923.x

M3 - Article

VL - 183

SP - 269

EP - 274

JO - European Journal of Biochemistry

JF - European Journal of Biochemistry

SN - 0014-2956

IS - 2

ER -

ID: 4799367