Impact of Particle Irradiation on the Immune System: From the Clinic to Mars

Research output: Contribution to journalLiterature review

Standard

Impact of Particle Irradiation on the Immune System : From the Clinic to Mars. / Fernandez Gonzalo, Rodrigo; Baatout, Sarah; Moreels, Marjan.

In: Frontiers in Immunology, Vol. 8, No. 177, 177, 22.02.2017.

Research output: Contribution to journalLiterature review

Bibtex - Download

@article{ef89a91f66a44ba99610164bfb915834,
title = "Impact of Particle Irradiation on the Immune System: From the Clinic to Mars",
abstract = "Despite the generalized use of photon-based radiation (i.e. gamma- and X-ray) to treat different cancer types, particle radiotherapy (i.e. protons and carbon ions) is becoming a popular, and more effective tool to treat specific tumors due to the improved physical properties and biological effectiveness. Current scientific evidence indicates conventional radiation therapy affects the tumor immunological profile in a particular manner, which in turn might induce beneficial effects both at local and systemic (i.e. abscopal effects) levels. The interaction between radiotherapy and the immune system is being explored to combine immune and radiation (including particles) treatments, which in many cases have a greater clinical effect than any of the therapies alone. Contrary to localized, clinical irradiation, astronauts are exposed to whole-body, chronic cosmic radiation, where protons and heavy ions are an important component. The effects of this extreme environment during long periods of time, e.g. a potential mission to Mars, will have an impact on the immune system that could jeopardize the health of the astronauts, hence the success of the mission. To this background, the purpose of this mini-review is to briefly present the current knowledge in local and systemic immune alterations triggered by particle irradiation, and to propose new lines of future research. Immune effects induced by particle radiation relevant to clinical applications will be covered, together with examples of combined radio- and immunotherapy. Then, the focus will move to outer space, where the immune system alterations induced by cosmic radiation during spaceflight will be discussed.",
keywords = "Particule therapy, Space radiation, Particule irradiation, immune system, clinical aspects, Mars",
author = "{Fernandez Gonzalo}, Rodrigo and Sarah Baatout and Marjan Moreels",
note = "Score=10",
year = "2017",
month = "2",
day = "22",
doi = "10.3389/fimmu.2017.00177",
language = "English",
volume = "8",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media",
number = "177",

}

RIS - Download

TY - JOUR

T1 - Impact of Particle Irradiation on the Immune System

T2 - From the Clinic to Mars

AU - Fernandez Gonzalo, Rodrigo

AU - Baatout, Sarah

AU - Moreels, Marjan

N1 - Score=10

PY - 2017/2/22

Y1 - 2017/2/22

N2 - Despite the generalized use of photon-based radiation (i.e. gamma- and X-ray) to treat different cancer types, particle radiotherapy (i.e. protons and carbon ions) is becoming a popular, and more effective tool to treat specific tumors due to the improved physical properties and biological effectiveness. Current scientific evidence indicates conventional radiation therapy affects the tumor immunological profile in a particular manner, which in turn might induce beneficial effects both at local and systemic (i.e. abscopal effects) levels. The interaction between radiotherapy and the immune system is being explored to combine immune and radiation (including particles) treatments, which in many cases have a greater clinical effect than any of the therapies alone. Contrary to localized, clinical irradiation, astronauts are exposed to whole-body, chronic cosmic radiation, where protons and heavy ions are an important component. The effects of this extreme environment during long periods of time, e.g. a potential mission to Mars, will have an impact on the immune system that could jeopardize the health of the astronauts, hence the success of the mission. To this background, the purpose of this mini-review is to briefly present the current knowledge in local and systemic immune alterations triggered by particle irradiation, and to propose new lines of future research. Immune effects induced by particle radiation relevant to clinical applications will be covered, together with examples of combined radio- and immunotherapy. Then, the focus will move to outer space, where the immune system alterations induced by cosmic radiation during spaceflight will be discussed.

AB - Despite the generalized use of photon-based radiation (i.e. gamma- and X-ray) to treat different cancer types, particle radiotherapy (i.e. protons and carbon ions) is becoming a popular, and more effective tool to treat specific tumors due to the improved physical properties and biological effectiveness. Current scientific evidence indicates conventional radiation therapy affects the tumor immunological profile in a particular manner, which in turn might induce beneficial effects both at local and systemic (i.e. abscopal effects) levels. The interaction between radiotherapy and the immune system is being explored to combine immune and radiation (including particles) treatments, which in many cases have a greater clinical effect than any of the therapies alone. Contrary to localized, clinical irradiation, astronauts are exposed to whole-body, chronic cosmic radiation, where protons and heavy ions are an important component. The effects of this extreme environment during long periods of time, e.g. a potential mission to Mars, will have an impact on the immune system that could jeopardize the health of the astronauts, hence the success of the mission. To this background, the purpose of this mini-review is to briefly present the current knowledge in local and systemic immune alterations triggered by particle irradiation, and to propose new lines of future research. Immune effects induced by particle radiation relevant to clinical applications will be covered, together with examples of combined radio- and immunotherapy. Then, the focus will move to outer space, where the immune system alterations induced by cosmic radiation during spaceflight will be discussed.

KW - Particule therapy

KW - Space radiation

KW - Particule irradiation

KW - immune system

KW - clinical aspects

KW - Mars

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/26068322

U2 - 10.3389/fimmu.2017.00177

DO - 10.3389/fimmu.2017.00177

M3 - Literature review

VL - 8

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

IS - 177

M1 - 177

ER -

ID: 3013729