Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects

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Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects. / Baatout, Sarah; Mejias-Pena, Yubisay N.; Estébanez, Brisamar; Rodriguez-Miguelez, Paula; Fernandez Gonzalo, Rodrigo; Almar, Mar; de Paz, José Antoinio; Gonzalez-Fernandez, Barbara; Cuevas, Maria J.

In: Aging, Vol. 9, No. 2, 02.02.2017, p. 408-418.

Research output: Contribution to journalArticlepeer-review

Harvard

Baatout, S, Mejias-Pena, YN, Estébanez, B, Rodriguez-Miguelez, P, Fernandez Gonzalo, R, Almar, M, de Paz, JA, Gonzalez-Fernandez, B & Cuevas, MJ 2017, 'Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects', Aging, vol. 9, no. 2, pp. 408-418. https://doi.org/10.18632/aging.101167

APA

Baatout, S., Mejias-Pena, Y. N., Estébanez, B., Rodriguez-Miguelez, P., Fernandez Gonzalo, R., Almar, M., de Paz, J. A., Gonzalez-Fernandez, B., & Cuevas, M. J. (2017). Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects. Aging, 9(2), 408-418. https://doi.org/10.18632/aging.101167

Vancouver

Author

Baatout, Sarah ; Mejias-Pena, Yubisay N. ; Estébanez, Brisamar ; Rodriguez-Miguelez, Paula ; Fernandez Gonzalo, Rodrigo ; Almar, Mar ; de Paz, José Antoinio ; Gonzalez-Fernandez, Barbara ; Cuevas, Maria J. / Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects. In: Aging. 2017 ; Vol. 9, No. 2. pp. 408-418.

Bibtex - Download

@article{bebaeb9845be4e2eaf2d566e23543c9a,
title = "Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects",
abstract = "Aging is associated with a decline in autophagy and a state of low-grade inflammation which further affects apoptosis and autophagy. Importantly, these alterations could reverse with regular physical activity. This study assessed the effects of a resistance exercise training program on autophagy, NLRP3 inflammasome, and apoptosis in peripheral blood mononuclear cells (PBMCs) from old subjects. Twenty-six healthy women and men (age, 69.6±1.5 yr) were randomized to a training (TG) or a control (CG) group. TG performed an 8-week resistance training program, while CG followed their daily routines. Protein expression of beclin-1, Atg12, Atg16 and LAMP-2 increased following the training program, while expression of p62/SQSTM1 and phosphorylation of ULK-1 at Ser757 were significantly lower. Resistance exercise also induced a decrease in NLRP3 expression and in the caspase-1/procaspase-1 ratio. Expression of Bcl-2 and Bcl-xL, as well as the Bad/BcL-2 ratio were reduced, and there was a significant decrease in the protein content of caspase-3. The results obtained seem to indicate that 8-week resistance training stimulates autophagy, prevents NLRP3 inflammasome activation, and reduces apoptosis in PBMCs from elderly subjects. These data could have a significant impact in prevention and rehabilitation programs currently employed in elderly population.",
keywords = "Apoptosis, Autophagy, Elderly, Inflammasome, Resistance exercise",
author = "Sarah Baatout and Mejias-Pena, {Yubisay N.} and Brisamar Est{\'e}banez and Paula Rodriguez-Miguelez and {Fernandez Gonzalo}, Rodrigo and Mar Almar and {de Paz}, {Jos{\'e} Antoinio} and Barbara Gonzalez-Fernandez and Cuevas, {Maria J.}",
note = "Score=10",
year = "2017",
month = feb,
day = "2",
doi = "10.18632/aging.101167",
language = "English",
volume = "9",
pages = "408--418",
journal = "Aging",
issn = "1945-4589",
publisher = "Impact Journals",
number = "2",

}

RIS - Download

TY - JOUR

T1 - Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects

AU - Baatout, Sarah

AU - Mejias-Pena, Yubisay N.

AU - Estébanez, Brisamar

AU - Rodriguez-Miguelez, Paula

AU - Fernandez Gonzalo, Rodrigo

AU - Almar, Mar

AU - de Paz, José Antoinio

AU - Gonzalez-Fernandez, Barbara

AU - Cuevas, Maria J.

N1 - Score=10

PY - 2017/2/2

Y1 - 2017/2/2

N2 - Aging is associated with a decline in autophagy and a state of low-grade inflammation which further affects apoptosis and autophagy. Importantly, these alterations could reverse with regular physical activity. This study assessed the effects of a resistance exercise training program on autophagy, NLRP3 inflammasome, and apoptosis in peripheral blood mononuclear cells (PBMCs) from old subjects. Twenty-six healthy women and men (age, 69.6±1.5 yr) were randomized to a training (TG) or a control (CG) group. TG performed an 8-week resistance training program, while CG followed their daily routines. Protein expression of beclin-1, Atg12, Atg16 and LAMP-2 increased following the training program, while expression of p62/SQSTM1 and phosphorylation of ULK-1 at Ser757 were significantly lower. Resistance exercise also induced a decrease in NLRP3 expression and in the caspase-1/procaspase-1 ratio. Expression of Bcl-2 and Bcl-xL, as well as the Bad/BcL-2 ratio were reduced, and there was a significant decrease in the protein content of caspase-3. The results obtained seem to indicate that 8-week resistance training stimulates autophagy, prevents NLRP3 inflammasome activation, and reduces apoptosis in PBMCs from elderly subjects. These data could have a significant impact in prevention and rehabilitation programs currently employed in elderly population.

AB - Aging is associated with a decline in autophagy and a state of low-grade inflammation which further affects apoptosis and autophagy. Importantly, these alterations could reverse with regular physical activity. This study assessed the effects of a resistance exercise training program on autophagy, NLRP3 inflammasome, and apoptosis in peripheral blood mononuclear cells (PBMCs) from old subjects. Twenty-six healthy women and men (age, 69.6±1.5 yr) were randomized to a training (TG) or a control (CG) group. TG performed an 8-week resistance training program, while CG followed their daily routines. Protein expression of beclin-1, Atg12, Atg16 and LAMP-2 increased following the training program, while expression of p62/SQSTM1 and phosphorylation of ULK-1 at Ser757 were significantly lower. Resistance exercise also induced a decrease in NLRP3 expression and in the caspase-1/procaspase-1 ratio. Expression of Bcl-2 and Bcl-xL, as well as the Bad/BcL-2 ratio were reduced, and there was a significant decrease in the protein content of caspase-3. The results obtained seem to indicate that 8-week resistance training stimulates autophagy, prevents NLRP3 inflammasome activation, and reduces apoptosis in PBMCs from elderly subjects. These data could have a significant impact in prevention and rehabilitation programs currently employed in elderly population.

KW - Apoptosis

KW - Autophagy

KW - Elderly

KW - Inflammasome

KW - Resistance exercise

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/35711056

U2 - 10.18632/aging.101167

DO - 10.18632/aging.101167

M3 - Article

VL - 9

SP - 408

EP - 418

JO - Aging

JF - Aging

SN - 1945-4589

IS - 2

ER -

ID: 5644262