In vitro dose-response comparison of [177Lu]Lu-labelled somatostatin receptor agonist and antagonist

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In vitro dose-response comparison of [177Lu]Lu-labelled somatostatin receptor agonist and antagonist. / Tamborino, Giulia; De Saint-Hubert, Marijke; Struelens, Lara; Dalm, Simone; Ruigrok, Eline A.M.; de Jong, Marion; Nonnekens, Julie; Konijnenberg, Mark W.

Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain: European Journal of Nuclear Medicine and Molecular Imaging volume . Vol. 46 2019. ed. 2019. p. S83-S84.

Research output: Contribution to report/book/conference proceedingsIn-proceedings paper

Harvard

Tamborino, G, De Saint-Hubert, M, Struelens, L, Dalm, S, Ruigrok, EAM, de Jong, M, Nonnekens, J & Konijnenberg, MW 2019, In vitro dose-response comparison of [177Lu]Lu-labelled somatostatin receptor agonist and antagonist. in Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain: European Journal of Nuclear Medicine and Molecular Imaging volume . 2019 edn, vol. 46, pp. S83-S84. https://doi.org/10.1007/s00259-019-04486-2

APA

Tamborino, G., De Saint-Hubert, M., Struelens, L., Dalm, S., Ruigrok, E. A. M., de Jong, M., ... Konijnenberg, M. W. (2019). In vitro dose-response comparison of [177Lu]Lu-labelled somatostatin receptor agonist and antagonist. In Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain: European Journal of Nuclear Medicine and Molecular Imaging volume (2019 ed., Vol. 46, pp. S83-S84) https://doi.org/10.1007/s00259-019-04486-2

Vancouver

Tamborino G, De Saint-Hubert M, Struelens L, Dalm S, Ruigrok EAM, de Jong M et al. In vitro dose-response comparison of [177Lu]Lu-labelled somatostatin receptor agonist and antagonist. In Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain: European Journal of Nuclear Medicine and Molecular Imaging volume . 2019 ed. Vol. 46. 2019. p. S83-S84 https://doi.org/10.1007/s00259-019-04486-2

Author

Tamborino, Giulia ; De Saint-Hubert, Marijke ; Struelens, Lara ; Dalm, Simone ; Ruigrok, Eline A.M. ; de Jong, Marion ; Nonnekens, Julie ; Konijnenberg, Mark W. / In vitro dose-response comparison of [177Lu]Lu-labelled somatostatin receptor agonist and antagonist. Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain: European Journal of Nuclear Medicine and Molecular Imaging volume . Vol. 46 2019. ed. 2019. pp. S83-S84

Bibtex - Download

@inproceedings{83160d87451448a49c90fc19efffec94,
title = "In vitro dose-response comparison of [177Lu]Lu-labelled somatostatin receptor agonist and antagonist",
abstract = "Peptide receptor radionuclide therapy (PRRT) using radiolabeled somatostatin receptor (SST) is very effective for treatment of neuroendocrine metastatic tumors. Recent studies indicate that radiolabeled SST antagonists show better tumor targeting during clinical imaging and preclinical therapy, despite little to no internalization in the cancer cells. However, preclinical studies are often limited to activity uptake, with no correlation between the delivered absorbed dose and the biological end-point. This study aims to calculate the absorbed dose to the nucleus for [177Lu]Lu-DOTA-Tyr3,octreotate (177Lu-DOTA-TATE, SST agonist) and [177Lu]Lu-DOTA-JR11 (177Lu- DOTA-JR11, SST antagonist), for comparison with DNA damage induction.",
keywords = "Double strand breaks, Targeted Radionuclide Therapy, Dose-response",
author = "Giulia Tamborino and {De Saint-Hubert}, Marijke and Lara Struelens and Simone Dalm and Ruigrok, {Eline A.M.} and {de Jong}, Marion and Julie Nonnekens and Konijnenberg, {Mark W.}",
note = "Score=3",
year = "2019",
month = "10",
day = "16",
doi = "10.1007/s00259-019-04486-2",
language = "English",
volume = "46",
pages = "S83--S84",
booktitle = "Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain",
edition = "2019",

}

RIS - Download

TY - GEN

T1 - In vitro dose-response comparison of [177Lu]Lu-labelled somatostatin receptor agonist and antagonist

AU - Tamborino, Giulia

AU - De Saint-Hubert, Marijke

AU - Struelens, Lara

AU - Dalm, Simone

AU - Ruigrok, Eline A.M.

AU - de Jong, Marion

AU - Nonnekens, Julie

AU - Konijnenberg, Mark W.

N1 - Score=3

PY - 2019/10/16

Y1 - 2019/10/16

N2 - Peptide receptor radionuclide therapy (PRRT) using radiolabeled somatostatin receptor (SST) is very effective for treatment of neuroendocrine metastatic tumors. Recent studies indicate that radiolabeled SST antagonists show better tumor targeting during clinical imaging and preclinical therapy, despite little to no internalization in the cancer cells. However, preclinical studies are often limited to activity uptake, with no correlation between the delivered absorbed dose and the biological end-point. This study aims to calculate the absorbed dose to the nucleus for [177Lu]Lu-DOTA-Tyr3,octreotate (177Lu-DOTA-TATE, SST agonist) and [177Lu]Lu-DOTA-JR11 (177Lu- DOTA-JR11, SST antagonist), for comparison with DNA damage induction.

AB - Peptide receptor radionuclide therapy (PRRT) using radiolabeled somatostatin receptor (SST) is very effective for treatment of neuroendocrine metastatic tumors. Recent studies indicate that radiolabeled SST antagonists show better tumor targeting during clinical imaging and preclinical therapy, despite little to no internalization in the cancer cells. However, preclinical studies are often limited to activity uptake, with no correlation between the delivered absorbed dose and the biological end-point. This study aims to calculate the absorbed dose to the nucleus for [177Lu]Lu-DOTA-Tyr3,octreotate (177Lu-DOTA-TATE, SST agonist) and [177Lu]Lu-DOTA-JR11 (177Lu- DOTA-JR11, SST antagonist), for comparison with DNA damage induction.

KW - Double strand breaks

KW - Targeted Radionuclide Therapy

KW - Dose-response

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/overview/37613315

U2 - 10.1007/s00259-019-04486-2

DO - 10.1007/s00259-019-04486-2

M3 - In-proceedings paper

VL - 46

SP - S83-S84

BT - Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain

ER -

ID: 6743654