Iodine deficiency induces a VEGF-dependent microvascular response in salivary glands and in the stomach

Research output: Contribution to journalArticle

Authors

  • Jessica Vanderstraeten
  • Hanane Derradji
  • Julie Craps
  • Pierre Sonveaux
  • Ides M. Colin
  • Marie-Christine Many
  • Anne-Catherine Gérard

Institutes & Expert groups

  • UCL - Université catholique de Louvain
  • CHR - Centre Hospitalier Régional Mons-Hainaut

Documents & links

Links

Abstract

Despite efforts to optimize iodine supply in iodine deficient countries, iodine deficiency (ID) remains a global problem worldwide. Activation of the local microvasculature by ID in the thyroid gland aims at improving the local supply of iodide. For this purpose, the thyrocytes secrete vascular endothelial growth factor (VEGF) that acts on adjacent capillaries, via a reactive oxygen species (ROS)/Hypoxia Inducible factor (HIF)- dependent pathway. Beside the thyroid, other organs including salivary glands and the stomach do express the sodium/iodide symporter (NIS) and are able to take iodide up, potentially rendering them sensitive to ID. To verify this hypothesis, ID-induced effects on the local microvasculature were studied in salivary glands and in the stomach. ID was induced by feeding young mice with an iodide-deficient diet and NIS inhibitor perchlorate in the drinking water. In salivary glands, ID induced a transient increase in HIF-1α protein expression accompanied by a transient, VEGFdependent increase in blood flow. In the gastric mucosa, ID transiently increased VEGF expression in the mucinsecreting epithelium and in ghrelin-secreting endocrine cells. These observations suggest that microvascular changes in response to ID occur in NIS-expressing tissues other than the thyroid. NIS expressing cells could be viewed as iodide sensors that respond to ID by inducing vascular changes, probably to optimize iodide bioavailability at regional or systemic levels.

Details

Original languageEnglish
Pages (from-to)897-909
JournalHistology and Histopathology
Volume31
Publication statusPublished - 30 Aug 2016

Keywords

  • Iodine deficiency , Salivary glands, Stomach, Microvasculature, VEGF

ID: 1440525