Iodine deficiency induces a VEGF-dependent microvascular response in salivary glands and in the stomach

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Iodine deficiency induces a VEGF-dependent microvascular response in salivary glands and in the stomach. / Vanderstraeten, Jessica; Derradji, Hanane; Craps, Julie; Sonveaux, Pierre; Colin, Ides M.; Many, Marie-Christine; Gérard, Anne-Catherine; Baatout, Sarah (Peer reviewer).

In: Histology and Histopathology, Vol. 31, 30.08.2016, p. 897-909.

Research output: Contribution to journalArticle

Harvard

Vanderstraeten, J, Derradji, H, Craps, J, Sonveaux, P, Colin, IM, Many, M-C, Gérard, A-C & Baatout, S 2016, 'Iodine deficiency induces a VEGF-dependent microvascular response in salivary glands and in the stomach', Histology and Histopathology, vol. 31, pp. 897-909.

APA

Vanderstraeten, J., Derradji, H., Craps, J., Sonveaux, P., Colin, I. M., Many, M-C., ... Baatout, S. (2016). Iodine deficiency induces a VEGF-dependent microvascular response in salivary glands and in the stomach. Histology and Histopathology, 31, 897-909.

Vancouver

Vanderstraeten J, Derradji H, Craps J, Sonveaux P, Colin IM, Many M-C et al. Iodine deficiency induces a VEGF-dependent microvascular response in salivary glands and in the stomach. Histology and Histopathology. 2016 Aug 30;31:897-909.

Author

Vanderstraeten, Jessica ; Derradji, Hanane ; Craps, Julie ; Sonveaux, Pierre ; Colin, Ides M. ; Many, Marie-Christine ; Gérard, Anne-Catherine ; Baatout, Sarah. / Iodine deficiency induces a VEGF-dependent microvascular response in salivary glands and in the stomach. In: Histology and Histopathology. 2016 ; Vol. 31. pp. 897-909.

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@article{922b90e803d642a2a66c656f9b74f3a1,
title = "Iodine deficiency induces a VEGF-dependent microvascular response in salivary glands and in the stomach",
abstract = "Despite efforts to optimize iodine supply in iodine deficient countries, iodine deficiency (ID) remains a global problem worldwide. Activation of the local microvasculature by ID in the thyroid gland aims at improving the local supply of iodide. For this purpose, the thyrocytes secrete vascular endothelial growth factor (VEGF) that acts on adjacent capillaries, via a reactive oxygen species (ROS)/Hypoxia Inducible factor (HIF)- dependent pathway. Beside the thyroid, other organs including salivary glands and the stomach do express the sodium/iodide symporter (NIS) and are able to take iodide up, potentially rendering them sensitive to ID. To verify this hypothesis, ID-induced effects on the local microvasculature were studied in salivary glands and in the stomach. ID was induced by feeding young mice with an iodide-deficient diet and NIS inhibitor perchlorate in the drinking water. In salivary glands, ID induced a transient increase in HIF-1α protein expression accompanied by a transient, VEGFdependent increase in blood flow. In the gastric mucosa, ID transiently increased VEGF expression in the mucinsecreting epithelium and in ghrelin-secreting endocrine cells. These observations suggest that microvascular changes in response to ID occur in NIS-expressing tissues other than the thyroid. NIS expressing cells could be viewed as iodide sensors that respond to ID by inducing vascular changes, probably to optimize iodide bioavailability at regional or systemic levels.",
keywords = "Iodine deficiency , Salivary glands, Stomach, Microvasculature, VEGF",
author = "Jessica Vanderstraeten and Hanane Derradji and Julie Craps and Pierre Sonveaux and Colin, {Ides M.} and Marie-Christine Many and Anne-Catherine G{\'e}rard and Sarah Baatout",
note = "Score=10",
year = "2016",
month = "8",
day = "30",
language = "English",
volume = "31",
pages = "897--909",
journal = "Histology and Histopathology",
issn = "0213-3911",
publisher = "Thomson",

}

RIS - Download

TY - JOUR

T1 - Iodine deficiency induces a VEGF-dependent microvascular response in salivary glands and in the stomach

AU - Vanderstraeten, Jessica

AU - Derradji, Hanane

AU - Craps, Julie

AU - Sonveaux, Pierre

AU - Colin, Ides M.

AU - Many, Marie-Christine

AU - Gérard, Anne-Catherine

A2 - Baatout, Sarah

N1 - Score=10

PY - 2016/8/30

Y1 - 2016/8/30

N2 - Despite efforts to optimize iodine supply in iodine deficient countries, iodine deficiency (ID) remains a global problem worldwide. Activation of the local microvasculature by ID in the thyroid gland aims at improving the local supply of iodide. For this purpose, the thyrocytes secrete vascular endothelial growth factor (VEGF) that acts on adjacent capillaries, via a reactive oxygen species (ROS)/Hypoxia Inducible factor (HIF)- dependent pathway. Beside the thyroid, other organs including salivary glands and the stomach do express the sodium/iodide symporter (NIS) and are able to take iodide up, potentially rendering them sensitive to ID. To verify this hypothesis, ID-induced effects on the local microvasculature were studied in salivary glands and in the stomach. ID was induced by feeding young mice with an iodide-deficient diet and NIS inhibitor perchlorate in the drinking water. In salivary glands, ID induced a transient increase in HIF-1α protein expression accompanied by a transient, VEGFdependent increase in blood flow. In the gastric mucosa, ID transiently increased VEGF expression in the mucinsecreting epithelium and in ghrelin-secreting endocrine cells. These observations suggest that microvascular changes in response to ID occur in NIS-expressing tissues other than the thyroid. NIS expressing cells could be viewed as iodide sensors that respond to ID by inducing vascular changes, probably to optimize iodide bioavailability at regional or systemic levels.

AB - Despite efforts to optimize iodine supply in iodine deficient countries, iodine deficiency (ID) remains a global problem worldwide. Activation of the local microvasculature by ID in the thyroid gland aims at improving the local supply of iodide. For this purpose, the thyrocytes secrete vascular endothelial growth factor (VEGF) that acts on adjacent capillaries, via a reactive oxygen species (ROS)/Hypoxia Inducible factor (HIF)- dependent pathway. Beside the thyroid, other organs including salivary glands and the stomach do express the sodium/iodide symporter (NIS) and are able to take iodide up, potentially rendering them sensitive to ID. To verify this hypothesis, ID-induced effects on the local microvasculature were studied in salivary glands and in the stomach. ID was induced by feeding young mice with an iodide-deficient diet and NIS inhibitor perchlorate in the drinking water. In salivary glands, ID induced a transient increase in HIF-1α protein expression accompanied by a transient, VEGFdependent increase in blood flow. In the gastric mucosa, ID transiently increased VEGF expression in the mucinsecreting epithelium and in ghrelin-secreting endocrine cells. These observations suggest that microvascular changes in response to ID occur in NIS-expressing tissues other than the thyroid. NIS expressing cells could be viewed as iodide sensors that respond to ID by inducing vascular changes, probably to optimize iodide bioavailability at regional or systemic levels.

KW - Iodine deficiency

KW - Salivary glands

KW - Stomach

KW - Microvasculature

KW - VEGF

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/19598155

M3 - Article

VL - 31

SP - 897

EP - 909

JO - Histology and Histopathology

JF - Histology and Histopathology

SN - 0213-3911

ER -

ID: 1440525