Ionizing radiation biomarkers in epidemiological studies – An update

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Ionizing radiation biomarkers in epidemiological studies – An update. / Hall, Janet; Jeggo, Penny; West, Catharine; Gomolka, Maria; Quintens, Roel; Badie, Christophe; Laurent, Olivier; Aerts, An; Anastasov, Natasa; Azimzadeh, Omid; Azizova, Tamara; Baatout, Sarah; Baselet, Bjorn; Benotmane, Rafi; Blanchardon, Eric; Gueguen, Yann; Haghdoost, Siamak; Harms-Ringhdahl, Mats; Hess, Julia; Kreuzer, Michaela; Laurier, Dominique; Macaeva, Ellina; Manning, Grainne; Pernot, Eileen; Ravanat, Jean-Luc; Sabatier, Laure; Tack, Karine; Tapio, Soile; Zitzelsberger, Horst; Cardis, Elizabeth.

In: Mutation Research/Reviews in Mutation Research, Vol. 771, 16.01.2017, p. 59-84.

Research output: Contribution to journalArticle

Harvard

Hall, J, Jeggo, P, West, C, Gomolka, M, Quintens, R, Badie, C, Laurent, O, Aerts, A, Anastasov, N, Azimzadeh, O, Azizova, T, Baatout, S, Baselet, B, Benotmane, R, Blanchardon, E, Gueguen, Y, Haghdoost, S, Harms-Ringhdahl, M, Hess, J, Kreuzer, M, Laurier, D, Macaeva, E, Manning, G, Pernot, E, Ravanat, J-L, Sabatier, L, Tack, K, Tapio, S, Zitzelsberger, H & Cardis, E 2017, 'Ionizing radiation biomarkers in epidemiological studies – An update', Mutation Research/Reviews in Mutation Research, vol. 771, pp. 59-84. https://doi.org/10.1016/j.mrrev.2017.01.001

APA

Hall, J., Jeggo, P., West, C., Gomolka, M., Quintens, R., Badie, C., ... Cardis, E. (2017). Ionizing radiation biomarkers in epidemiological studies – An update. Mutation Research/Reviews in Mutation Research, 771, 59-84. https://doi.org/10.1016/j.mrrev.2017.01.001

Vancouver

Hall J, Jeggo P, West C, Gomolka M, Quintens R, Badie C et al. Ionizing radiation biomarkers in epidemiological studies – An update. Mutation Research/Reviews in Mutation Research. 2017 Jan 16;771:59-84. https://doi.org/10.1016/j.mrrev.2017.01.001

Author

Hall, Janet ; Jeggo, Penny ; West, Catharine ; Gomolka, Maria ; Quintens, Roel ; Badie, Christophe ; Laurent, Olivier ; Aerts, An ; Anastasov, Natasa ; Azimzadeh, Omid ; Azizova, Tamara ; Baatout, Sarah ; Baselet, Bjorn ; Benotmane, Rafi ; Blanchardon, Eric ; Gueguen, Yann ; Haghdoost, Siamak ; Harms-Ringhdahl, Mats ; Hess, Julia ; Kreuzer, Michaela ; Laurier, Dominique ; Macaeva, Ellina ; Manning, Grainne ; Pernot, Eileen ; Ravanat, Jean-Luc ; Sabatier, Laure ; Tack, Karine ; Tapio, Soile ; Zitzelsberger, Horst ; Cardis, Elizabeth. / Ionizing radiation biomarkers in epidemiological studies – An update. In: Mutation Research/Reviews in Mutation Research. 2017 ; Vol. 771. pp. 59-84.

Bibtex - Download

@article{3adefd11bb62418fb23d7ac4e3cc1a62,
title = "Ionizing radiation biomarkers in epidemiological studies – An update",
abstract = "Recent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown increased leukaemia and solid tumour risks following cumulative doses of of <100 mSv and dose rates of <10 mGy per year; paediatric patients studies have reported increased leukaemia and brain tumours risks after doses of 30–60 mGy from computed tomography scans. Questions arise, however, about the impact of even lower doses and dose rates where classical epidemiological studies have limited power but where subsets within the large cohorts are expected to have an increased risk. Further progress requires integration of biomarkers or bioassays of individual exposure, effects and susceptibility to IR. The European DoReMi (Low Dose Research towards Multidisciplinary Integration) consortium previously reviewed biomarkers for potential use in IR epidemiological studies. Given the increased mechanistic understanding of responses to low dose radiation the current review provides an update covering technical advances and recent studies. A key issue identified is deciding which biomarkers to progress. A roadmap is provided for biomarker development from discovery to implementation and used to summarise the current status of proposed biomarkers for epidemiological studies. Most potential biomarkers remain at the discovery stage and for some there is sufficient evidence that further development is not warranted.",
keywords = "biomarkers, effects, exposure, individual sensitivity, ionizing radiation, molecular epidemiology",
author = "Janet Hall and Penny Jeggo and Catharine West and Maria Gomolka and Roel Quintens and Christophe Badie and Olivier Laurent and An Aerts and Natasa Anastasov and Omid Azimzadeh and Tamara Azizova and Sarah Baatout and Bjorn Baselet and Rafi Benotmane and Eric Blanchardon and Yann Gueguen and Siamak Haghdoost and Mats Harms-Ringhdahl and Julia Hess and Michaela Kreuzer and Dominique Laurier and Ellina Macaeva and Grainne Manning and Eileen Pernot and Jean-Luc Ravanat and Laure Sabatier and Karine Tack and Soile Tapio and Horst Zitzelsberger and Elizabeth Cardis",
note = "Score=10",
year = "2017",
month = "1",
day = "16",
doi = "10.1016/j.mrrev.2017.01.001",
language = "English",
volume = "771",
pages = "59--84",
journal = "Mutation Research/Reviews in Mutation Research",
issn = "1383-5742",
publisher = "Elsevier",

}

RIS - Download

TY - JOUR

T1 - Ionizing radiation biomarkers in epidemiological studies – An update

AU - Hall, Janet

AU - Jeggo, Penny

AU - West, Catharine

AU - Gomolka, Maria

AU - Quintens, Roel

AU - Badie, Christophe

AU - Laurent, Olivier

AU - Aerts, An

AU - Anastasov, Natasa

AU - Azimzadeh, Omid

AU - Azizova, Tamara

AU - Baatout, Sarah

AU - Baselet, Bjorn

AU - Benotmane, Rafi

AU - Blanchardon, Eric

AU - Gueguen, Yann

AU - Haghdoost, Siamak

AU - Harms-Ringhdahl, Mats

AU - Hess, Julia

AU - Kreuzer, Michaela

AU - Laurier, Dominique

AU - Macaeva, Ellina

AU - Manning, Grainne

AU - Pernot, Eileen

AU - Ravanat, Jean-Luc

AU - Sabatier, Laure

AU - Tack, Karine

AU - Tapio, Soile

AU - Zitzelsberger, Horst

AU - Cardis, Elizabeth

N1 - Score=10

PY - 2017/1/16

Y1 - 2017/1/16

N2 - Recent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown increased leukaemia and solid tumour risks following cumulative doses of of <100 mSv and dose rates of <10 mGy per year; paediatric patients studies have reported increased leukaemia and brain tumours risks after doses of 30–60 mGy from computed tomography scans. Questions arise, however, about the impact of even lower doses and dose rates where classical epidemiological studies have limited power but where subsets within the large cohorts are expected to have an increased risk. Further progress requires integration of biomarkers or bioassays of individual exposure, effects and susceptibility to IR. The European DoReMi (Low Dose Research towards Multidisciplinary Integration) consortium previously reviewed biomarkers for potential use in IR epidemiological studies. Given the increased mechanistic understanding of responses to low dose radiation the current review provides an update covering technical advances and recent studies. A key issue identified is deciding which biomarkers to progress. A roadmap is provided for biomarker development from discovery to implementation and used to summarise the current status of proposed biomarkers for epidemiological studies. Most potential biomarkers remain at the discovery stage and for some there is sufficient evidence that further development is not warranted.

AB - Recent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown increased leukaemia and solid tumour risks following cumulative doses of of <100 mSv and dose rates of <10 mGy per year; paediatric patients studies have reported increased leukaemia and brain tumours risks after doses of 30–60 mGy from computed tomography scans. Questions arise, however, about the impact of even lower doses and dose rates where classical epidemiological studies have limited power but where subsets within the large cohorts are expected to have an increased risk. Further progress requires integration of biomarkers or bioassays of individual exposure, effects and susceptibility to IR. The European DoReMi (Low Dose Research towards Multidisciplinary Integration) consortium previously reviewed biomarkers for potential use in IR epidemiological studies. Given the increased mechanistic understanding of responses to low dose radiation the current review provides an update covering technical advances and recent studies. A key issue identified is deciding which biomarkers to progress. A roadmap is provided for biomarker development from discovery to implementation and used to summarise the current status of proposed biomarkers for epidemiological studies. Most potential biomarkers remain at the discovery stage and for some there is sufficient evidence that further development is not warranted.

KW - biomarkers

KW - effects

KW - exposure

KW - individual sensitivity

KW - ionizing radiation

KW - molecular epidemiology

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/21847763

U2 - 10.1016/j.mrrev.2017.01.001

DO - 10.1016/j.mrrev.2017.01.001

M3 - Article

VL - 771

SP - 59

EP - 84

JO - Mutation Research/Reviews in Mutation Research

JF - Mutation Research/Reviews in Mutation Research

SN - 1383-5742

ER -

ID: 2118754