Ionizing radiation-induced circulatory and metabolic diseases

Research output: Contribution to journalArticle

Authors

  • Soile Tapio
  • Mark P. Little
  • Jan Christian Kaiser
  • Nathalie Impens
  • Nobuvuki Hamada
  • Alexandros G. Georgakilas

Institutes & Expert groups

  • NCI - National Cancer Institute
  • CRIEPI - Central Research Institute of Electric Power Industry
  • NTUA - National Technical University of Athens
  • HMGU - Helmholtz Zentrum München - German Research Center for Environmental Health

Documents & links

Abstract

Risks to health are the prime consideration in all human situations of ionizing radiation exposure and therefore of relevance to radiation protection in all occupational, medical, and public exposure situations. Over the past few decades, advances in therapeutic strategies have led to significant improvements in cancer survival rates. However, a wide range of long-term complications have been reported in cancer survivors, in particular circulatory diseases and their major risk factors, metabolic diseases. However, at lower levels of exposure, the evidence is less clear. Under real-life exposure scenarios, including radiotherapy, radiation effects in the whole organism will be determined mainly by the response of normal tissues receiving relatively low doses, and will be mediated and moderated by systemic effects. Therefore, there is an urgent need for further research on the impact of low-dose radiation. In this article, we review radiation-associated risks of circulatory and metabolic diseases in clinical, occupational or environmental exposure situations, addressing epidemiological, biological, risk modelling, and systems biology aspects, highlight the gaps in knowledge and discuss future directions to address these gaps.

Details

Original languageEnglish
Article number106235
Pages (from-to)1-16
Number of pages16
JournalEnvironmental International
Volume146
DOIs
Publication statusPublished - 1 Jan 2021

Keywords

  • Ionizing radiation, Circulatory disease, Heart, Endothelial, Metabolic syndrome, Radiotherapy, Systems biology

ID: 6978783