Abstract
In this paper, the cellular and molecular mechanisms underlying radiation-induced forelimb defects were studied. Our data suggest that transcriptional modulations of apoptotic, inflammation, stress, and DNA damage players are early events in radiation-induced forelimb defects. These changes resulted in harsh developmental conditions as indicated by a marked increase in cytokine levels in the amniotic fluid and telomere shortening, two features concomitant with the onset of the forelimb defect phenotype in our study.
Details
Original language | English |
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Pages (from-to) | 302-313 |
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Journal | Developmental Biology |
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Volume | 322 |
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Issue number | 2 |
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DOIs | |
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Publication status | Published - Oct 2008 |
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