Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects
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Abstract
In this paper, the cellular and molecular mechanisms underlying radiation-induced forelimb defects were studied. Our data suggest that transcriptional modulations of apoptotic, inflammation, stress, and DNA damage players are early events in radiation-induced forelimb defects. These changes resulted in harsh developmental conditions as indicated by a marked increase in cytokine levels in the amniotic fluid and telomere shortening, two features concomitant with the onset of the forelimb defect phenotype in our study.
Details
| Original language | English |
|---|---|
| Pages (from-to) | 302-313 |
| Journal | Developmental Biology |
| Volume | 322 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Oct 2008 |
Keywords
- Limb defect, radiation, teratogenesis, apoptosis, telomere shortening, inflammation, cytokines, signal transduction.
ID: 307074