Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects

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Abstract

In this paper, the cellular and molecular mechanisms underlying radiation-induced forelimb defects were studied. Our data suggest that transcriptional modulations of apoptotic, inflammation, stress, and DNA damage players are early events in radiation-induced forelimb defects. These changes resulted in harsh developmental conditions as indicated by a marked increase in cytokine levels in the amniotic fluid and telomere shortening, two features concomitant with the onset of the forelimb defect phenotype in our study.

Details

Original languageEnglish
Pages (from-to)302-313
JournalDevelopmental Biology
Volume322
Issue number2
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Limb defect, radiation, teratogenesis, apoptosis, telomere shortening, inflammation, cytokines, signal transduction.

ID: 307074