Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects

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In this paper, the cellular and molecular mechanisms underlying radiation-induced forelimb defects were studied. Our data suggest that transcriptional modulations of apoptotic, inflammation, stress, and DNA damage players are early events in radiation-induced forelimb defects. These changes resulted in harsh developmental conditions as indicated by a marked increase in cytokine levels in the amniotic fluid and telomere shortening, two features concomitant with the onset of the forelimb defect phenotype in our study.


Original languageEnglish
Pages (from-to)302-313
JournalDevelopmental Biology
Issue number2
Publication statusPublished - Oct 2008


  • Limb defect, radiation, teratogenesis, apoptosis, telomere shortening, inflammation, cytokines, signal transduction.

ID: 307074