Lack of mutagenic activity of dimethylformamide

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Lack of mutagenic activity of dimethylformamide. / Antoine, J. L. ; Arany, J. .

In: Toxicology, Vol. 26, No. 3-4, 01.01.1983, p. 207-212.

Research output: Contribution to journalArticle

Harvard

Antoine, JL & Arany, J 1983, 'Lack of mutagenic activity of dimethylformamide', Toxicology, vol. 26, no. 3-4, pp. 207-212. https://doi.org/10.1016/0300-483X(83)90082-3

APA

Antoine, J. L., & Arany, J. (1983). Lack of mutagenic activity of dimethylformamide. Toxicology, 26(3-4), 207-212. https://doi.org/10.1016/0300-483X(83)90082-3

Vancouver

Antoine JL, Arany J. Lack of mutagenic activity of dimethylformamide. Toxicology. 1983 Jan 1;26(3-4):207-212. https://doi.org/10.1016/0300-483X(83)90082-3

Author

Antoine, J. L. ; Arany, J. . / Lack of mutagenic activity of dimethylformamide. In: Toxicology. 1983 ; Vol. 26, No. 3-4. pp. 207-212.

Bibtex - Download

@article{0413eb23899a4f60bec61ba9e5292256,
title = "Lack of mutagenic activity of dimethylformamide",
abstract = "Different test systems have been utilized to evaluate the mutagenic and carcinogenic properties of dimethylformamide (DMF), an aliphatic amide used as a solvent in chemical industry. The Ames test was performed on different strains of Salmonella typhimurium, whereas the ability of DMF to induce structural aberrations in eukaryotic chromosomes was tested by in vitro observations on human lymphocytes and in vivo experiments on mouse bone marrow. Furthermore, male mice were treated with DMF for the induction of sperm abnormalities. The negative results obtained in all test systems as well as the absence of positive reports in man or in experimental animals with respect to induction of cancers suggeests strongly that DMF is devoid of mutagenic or carcinogenic properties",
keywords = "Mutagenicity, Dimethylformamide",
author = "Antoine, {J. L.} and J. Arany",
year = "1983",
month = "1",
day = "1",
doi = "10.1016/0300-483X(83)90082-3",
language = "English",
volume = "26",
pages = "207--212",
journal = "Toxicology",
issn = "0300-483X",
publisher = "Elsevier",
number = "3-4",

}

RIS - Download

TY - JOUR

T1 - Lack of mutagenic activity of dimethylformamide

AU - Antoine, J. L.

AU - Arany, J.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - Different test systems have been utilized to evaluate the mutagenic and carcinogenic properties of dimethylformamide (DMF), an aliphatic amide used as a solvent in chemical industry. The Ames test was performed on different strains of Salmonella typhimurium, whereas the ability of DMF to induce structural aberrations in eukaryotic chromosomes was tested by in vitro observations on human lymphocytes and in vivo experiments on mouse bone marrow. Furthermore, male mice were treated with DMF for the induction of sperm abnormalities. The negative results obtained in all test systems as well as the absence of positive reports in man or in experimental animals with respect to induction of cancers suggeests strongly that DMF is devoid of mutagenic or carcinogenic properties

AB - Different test systems have been utilized to evaluate the mutagenic and carcinogenic properties of dimethylformamide (DMF), an aliphatic amide used as a solvent in chemical industry. The Ames test was performed on different strains of Salmonella typhimurium, whereas the ability of DMF to induce structural aberrations in eukaryotic chromosomes was tested by in vitro observations on human lymphocytes and in vivo experiments on mouse bone marrow. Furthermore, male mice were treated with DMF for the induction of sperm abnormalities. The negative results obtained in all test systems as well as the absence of positive reports in man or in experimental animals with respect to induction of cancers suggeests strongly that DMF is devoid of mutagenic or carcinogenic properties

KW - Mutagenicity

KW - Dimethylformamide

UR - https://ecm.sckcen.be/OTCS/llisapi.dll?func=ll&objaction=overview&objid=32306014

U2 - 10.1016/0300-483X(83)90082-3

DO - 10.1016/0300-483X(83)90082-3

M3 - Article

VL - 26

SP - 207

EP - 212

JO - Toxicology

JF - Toxicology

SN - 0300-483X

IS - 3-4

ER -

ID: 4785248