Media Ion Composition Controls Regulatory and Virulence Response of Salmonellain Spaceflight

Research output: Contribution to journalArticle

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Media Ion Composition Controls Regulatory and Virulence Response of Salmonellain Spaceflight. / Wilson, James; Ott, Mark; Quick, Laura; Davis, Richard; Höner zu Bentrup, Kerstin; Crabbé, Aurélie; Richter, Emily; Sarker, Shameema; Barrila, Jennifer; Porwollik, Steffen; Cheng, Pui; McClelland, Michael; Tsapraillis, George; Radabaugh, Timothy; Hunt, Andrea; Shah, Miti; Nelman-Gonzalez, Mayra; Hing, Steve; Perra, Macarena; Dumars, Paula; Norwood, Kelly; Bober, Ramona; Devich, Jennifer; Ruggles, Ashleigh; CdeBaca, Autumn; Narayan, Satro; Benjamin, Joseph; Goulart, Carla; Rupert, Mark; Catella, Luke; Schurr, Michael; Buchanan, Kent; Morici, Lisa; McCracken, James; Porter, Marc; Pierson, Duane; Smith, Scott; Mergeay, Max; Leys, Natalie; Stefanyshyn-Piper, Heidemarie; Gorie, Dominic; Nickerson, Cheryl.

In: PLOS ONE, Vol. 3, No. 12, 12.2008, p. e3923-e3923.

Research output: Contribution to journalArticle

Harvard

Wilson, J, Ott, M, Quick, L, Davis, R, Höner zu Bentrup, K, Crabbé, A, Richter, E, Sarker, S, Barrila, J, Porwollik, S, Cheng, P, McClelland, M, Tsapraillis, G, Radabaugh, T, Hunt, A, Shah, M, Nelman-Gonzalez, M, Hing, S, Perra, M, Dumars, P, Norwood, K, Bober, R, Devich, J, Ruggles, A, CdeBaca, A, Narayan, S, Benjamin, J, Goulart, C, Rupert, M, Catella, L, Schurr, M, Buchanan, K, Morici, L, McCracken, J, Porter, M, Pierson, D, Smith, S, Mergeay, M, Leys, N, Stefanyshyn-Piper, H, Gorie, D & Nickerson, C 2008, 'Media Ion Composition Controls Regulatory and Virulence Response of Salmonellain Spaceflight' PLOS ONE, vol 3, no. 12, pp. e3923-e3923. DOI: 10.1371/journal.pone.0003923

APA

Wilson, J., Ott, M., Quick, L., Davis, R., Höner zu Bentrup, K., Crabbé, A., ... Nickerson, C. (2008). Media Ion Composition Controls Regulatory and Virulence Response of Salmonellain Spaceflight. PLOS ONE, 3(12), e3923-e3923. DOI: 10.1371/journal.pone.0003923

Vancouver

Wilson J, Ott M, Quick L, Davis R, Höner zu Bentrup K, Crabbé A et al. Media Ion Composition Controls Regulatory and Virulence Response of Salmonellain Spaceflight. PLOS ONE. 2008 Dec;3(12):e3923-e3923. Available from, DOI: 10.1371/journal.pone.0003923

Author

Wilson, James; Ott, Mark; Quick, Laura; Davis, Richard; Höner zu Bentrup, Kerstin; Crabbé, Aurélie; Richter, Emily; Sarker, Shameema; Barrila, Jennifer; Porwollik, Steffen; Cheng, Pui; McClelland, Michael; Tsapraillis, George; Radabaugh, Timothy; Hunt, Andrea; Shah, Miti; Nelman-Gonzalez, Mayra; Hing, Steve; Perra, Macarena; Dumars, Paula; Norwood, Kelly; Bober, Ramona; Devich, Jennifer; Ruggles, Ashleigh; CdeBaca, Autumn; Narayan, Satro; Benjamin, Joseph; Goulart, Carla; Rupert, Mark; Catella, Luke; Schurr, Michael; Buchanan, Kent; Morici, Lisa; McCracken, James; Porter, Marc; Pierson, Duane; Smith, Scott; Mergeay, Max; Leys, Natalie; Stefanyshyn-Piper, Heidemarie; Gorie, Dominic; Nickerson, Cheryl / Media Ion Composition Controls Regulatory and Virulence Response of Salmonellain Spaceflight.

In: PLOS ONE, Vol. 3, No. 12, 12.2008, p. e3923-e3923.

Research output: Contribution to journalArticle

Bibtex - Download

@article{457036432ad447eea070439160e7b057,
title = "Media Ion Composition Controls Regulatory and Virulence Response of Salmonellain Spaceflight",
keywords = "Salmonella, spaceflight, virulence",
author = "James Wilson and Mark Ott and Laura Quick and Richard Davis and {Höner zu Bentrup}, Kerstin and Aurélie Crabbé and Emily Richter and Shameema Sarker and Jennifer Barrila and Steffen Porwollik and Pui Cheng and Michael McClelland and George Tsapraillis and Timothy Radabaugh and Andrea Hunt and Miti Shah and Mayra Nelman-Gonzalez and Steve Hing and Macarena Perra and Paula Dumars and Kelly Norwood and Ramona Bober and Jennifer Devich and Ashleigh Ruggles and Autumn CdeBaca and Satro Narayan and Joseph Benjamin and Carla Goulart and Mark Rupert and Luke Catella and Michael Schurr and Kent Buchanan and Lisa Morici and James McCracken and Marc Porter and Duane Pierson and Scott Smith and Max Mergeay and Natalie Leys and Heidemarie Stefanyshyn-Piper and Dominic Gorie and Cheryl Nickerson",
note = "Score = 10",
year = "2008",
month = "12",
doi = "10.1371/journal.pone.0003923",
volume = "3",
pages = "e3923--e3923",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "PLOS - Public Library of Science",
number = "12",

}

RIS - Download

TY - JOUR

T1 - Media Ion Composition Controls Regulatory and Virulence Response of Salmonellain Spaceflight

AU - Wilson,James

AU - Ott,Mark

AU - Quick,Laura

AU - Davis,Richard

AU - Höner zu Bentrup,Kerstin

AU - Crabbé,Aurélie

AU - Richter,Emily

AU - Sarker,Shameema

AU - Barrila,Jennifer

AU - Porwollik,Steffen

AU - Cheng,Pui

AU - McClelland,Michael

AU - Tsapraillis,George

AU - Radabaugh,Timothy

AU - Hunt,Andrea

AU - Shah,Miti

AU - Nelman-Gonzalez,Mayra

AU - Hing,Steve

AU - Perra,Macarena

AU - Dumars,Paula

AU - Norwood,Kelly

AU - Bober,Ramona

AU - Devich,Jennifer

AU - Ruggles,Ashleigh

AU - CdeBaca,Autumn

AU - Narayan,Satro

AU - Benjamin,Joseph

AU - Goulart,Carla

AU - Rupert,Mark

AU - Catella,Luke

AU - Schurr,Michael

AU - Buchanan,Kent

AU - Morici,Lisa

AU - McCracken,James

AU - Porter,Marc

AU - Pierson,Duane

AU - Smith,Scott

AU - Mergeay,Max

AU - Leys,Natalie

AU - Stefanyshyn-Piper,Heidemarie

AU - Gorie,Dominic

AU - Nickerson,Cheryl

N1 - Score = 10

PY - 2008/12

Y1 - 2008/12

N2 - The spaceflight environment is relevant to conditions encountered by pathogens during the course of infection and induces novel changes in microbial pathogenesis not observed using conventional methods. It is unclear how microbial cells sense spaceflight-associated changes to their growth environment and orchestrate corresponding changes in molecular and physiological phenotypes relevant to the infection process. Here we report that spaceflight-induced increases in Salmonella virulence are regulated by media ion composition, and that phosphate ion is sufficient to alter related pathogenesis responses in a spaceflight analogue model. Using whole genome microarray and proteomic analyses from two independent Space Shuttle missions, we identified evolutionarily conserved molecular pathways in Salmonella that respond to spaceflight under all media compositions tested. Identification of conserved regulatory paradigms opens new avenues to control microbial responses during the infection process and holds promise to provide an improved understanding of human health and disease on Earth.

AB - The spaceflight environment is relevant to conditions encountered by pathogens during the course of infection and induces novel changes in microbial pathogenesis not observed using conventional methods. It is unclear how microbial cells sense spaceflight-associated changes to their growth environment and orchestrate corresponding changes in molecular and physiological phenotypes relevant to the infection process. Here we report that spaceflight-induced increases in Salmonella virulence are regulated by media ion composition, and that phosphate ion is sufficient to alter related pathogenesis responses in a spaceflight analogue model. Using whole genome microarray and proteomic analyses from two independent Space Shuttle missions, we identified evolutionarily conserved molecular pathways in Salmonella that respond to spaceflight under all media compositions tested. Identification of conserved regulatory paradigms opens new avenues to control microbial responses during the infection process and holds promise to provide an improved understanding of human health and disease on Earth.

KW - Salmonella

KW - spaceflight

KW - virulence

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_93103

UR - http://knowledgecentre.sckcen.be/so2/bibref/5387

U2 - 10.1371/journal.pone.0003923

DO - 10.1371/journal.pone.0003923

M3 - Article

VL - 3

SP - e3923-e3923

JO - PLOS ONE

T2 - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 12

ER -

ID: 354856