Metabolic changes associated with tumor metastasis, part 1-tumor pH, glycolysis and the pentose phosphate pathway

Research output: Contribution to journalArticle

Standard

Metabolic changes associated with tumor metastasis, part 1-tumor pH, glycolysis and the pentose phosphate pathway. / Payen, Valery L.; Porporato, Paolo E.; Baselet, Bjorn; Sonveaux, Pierre.

In: Cellular and Molecular Life Science, Vol. 73, No. 7, 19.11.2015, p. 1333-48.

Research output: Contribution to journalArticle

Harvard

Payen, VL, Porporato, PE, Baselet, B & Sonveaux, P 2015, 'Metabolic changes associated with tumor metastasis, part 1-tumor pH, glycolysis and the pentose phosphate pathway', Cellular and Molecular Life Science, vol. 73, no. 7, pp. 1333-48. https://doi.org/10.1007/s00018-015-2098-5

APA

Vancouver

Author

Payen, Valery L. ; Porporato, Paolo E. ; Baselet, Bjorn ; Sonveaux, Pierre. / Metabolic changes associated with tumor metastasis, part 1-tumor pH, glycolysis and the pentose phosphate pathway. In: Cellular and Molecular Life Science. 2015 ; Vol. 73, No. 7. pp. 1333-48.

Bibtex - Download

@article{8c1123861f83400bbee0106f534b2385,
title = "Metabolic changes associated with tumor metastasis, part 1-tumor pH, glycolysis and the pentose phosphate pathway",
abstract = "Metabolic adaptations are intimately associated with changes in cell behavior. Cancers are characterized by a high metabolic plasticity resulting from mutations and the selection of metabolic phenotypes conferring growth and invasive advantages. While metabolic plasticity allows cancer cells to cope with various microenvironmental situations that can be encountered in a primary tumor, there is increasing evidence that metabolism is also a major driver of cancer metastasis. Rather than a general switch promoting metastasis as a whole, a succession of metabolic adaptations is more likely needed to promote different steps of the metastatic process. This review addresses the contribution of pH, glycolysis and the pentose phosphate pathway, and a companion paper summarizes current knowledge regarding the contribution of mitochondria, lipids and amino acid metabolism. Extracellular acidification, intracellular alkalinization, the glycolytic enzyme phosphoglucose isomerase acting as an autocrine cytokine, lactate and the pentose phosphate pathway are emerging as important factors controlling cancer metastasis.",
keywords = "Glycolysis, Lactate, Pentose phosphate pathway (PPP), Phosphoglucose isomerase (PGI), Tumor metastasis, Tumor pH",
author = "Payen, {Valery L.} and Porporato, {Paolo E.} and Bjorn Baselet and Pierre Sonveaux",
note = "Score=10",
year = "2015",
month = "11",
day = "19",
doi = "10.1007/s00018-015-2098-5",
language = "English",
volume = "73",
pages = "1333--48",
journal = "Cellular and Molecular Life Science",
issn = "1420-682X",
publisher = "Springer",
number = "7",

}

RIS - Download

TY - JOUR

T1 - Metabolic changes associated with tumor metastasis, part 1-tumor pH, glycolysis and the pentose phosphate pathway

AU - Payen, Valery L.

AU - Porporato, Paolo E.

AU - Baselet, Bjorn

AU - Sonveaux, Pierre

N1 - Score=10

PY - 2015/11/19

Y1 - 2015/11/19

N2 - Metabolic adaptations are intimately associated with changes in cell behavior. Cancers are characterized by a high metabolic plasticity resulting from mutations and the selection of metabolic phenotypes conferring growth and invasive advantages. While metabolic plasticity allows cancer cells to cope with various microenvironmental situations that can be encountered in a primary tumor, there is increasing evidence that metabolism is also a major driver of cancer metastasis. Rather than a general switch promoting metastasis as a whole, a succession of metabolic adaptations is more likely needed to promote different steps of the metastatic process. This review addresses the contribution of pH, glycolysis and the pentose phosphate pathway, and a companion paper summarizes current knowledge regarding the contribution of mitochondria, lipids and amino acid metabolism. Extracellular acidification, intracellular alkalinization, the glycolytic enzyme phosphoglucose isomerase acting as an autocrine cytokine, lactate and the pentose phosphate pathway are emerging as important factors controlling cancer metastasis.

AB - Metabolic adaptations are intimately associated with changes in cell behavior. Cancers are characterized by a high metabolic plasticity resulting from mutations and the selection of metabolic phenotypes conferring growth and invasive advantages. While metabolic plasticity allows cancer cells to cope with various microenvironmental situations that can be encountered in a primary tumor, there is increasing evidence that metabolism is also a major driver of cancer metastasis. Rather than a general switch promoting metastasis as a whole, a succession of metabolic adaptations is more likely needed to promote different steps of the metastatic process. This review addresses the contribution of pH, glycolysis and the pentose phosphate pathway, and a companion paper summarizes current knowledge regarding the contribution of mitochondria, lipids and amino acid metabolism. Extracellular acidification, intracellular alkalinization, the glycolytic enzyme phosphoglucose isomerase acting as an autocrine cytokine, lactate and the pentose phosphate pathway are emerging as important factors controlling cancer metastasis.

KW - Glycolysis

KW - Lactate

KW - Pentose phosphate pathway (PPP)

KW - Phosphoglucose isomerase (PGI)

KW - Tumor metastasis

KW - Tumor pH

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/20018409

UR - https://www.ncbi.nlm.nih.gov/pubmed/26626411

U2 - 10.1007/s00018-015-2098-5

DO - 10.1007/s00018-015-2098-5

M3 - Article

VL - 73

SP - 1333

EP - 1348

JO - Cellular and Molecular Life Science

JF - Cellular and Molecular Life Science

SN - 1420-682X

IS - 7

ER -

ID: 1527293